Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.600 Biomarker disease PSYGENET Because dopaminergic disturbance is thought to be involved in the development of bipolar disorder (BPD), it seems essential to investigate dopamine-related genes like the catechol-O-methyltransferase (COMT) gene, which are involved in dopamine metabolism, and the methylenetetrahydrofolate reductase (MTHFR) gene, which may affect COMT methylation and COMT function. 25744938 2015
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.600 Biomarker disease PSYGENET Methylenetetrahydrofolate reductase (MTHFR) polymorphism susceptibility to schizophrenia and bipolar disorder: an updated meta-analysis. 24938371 2015
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.600 GeneticVariation disease BEFREE Methylenetetrahydrofolate reductase (MTHFR) polymorphism susceptibility to schizophrenia and bipolar disorder: an updated meta-analysis. 24938371 2015
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.600 GeneticVariation disease BEFREE The present findings suggest that the MTHFR C677T polymorphisms are likely to be associated with the risk of developing BD and schizophrenia and influence the age at onset of BD but not the age at onset of schizophrenia. 25101272 2014
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.600 GeneticVariation disease BEFREE We were unable to confirm an association between bipolar disorder and C677T polymorphism (rs1801133) of the MTHFR gene, as suggested in some previous studies. 24577139 2014
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.600 Biomarker disease PSYGENET Of the genes connected with homocysteine metabolism, some studies have found an association between polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene and bipolar disorder. 24577139 2014
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.600 Biomarker disease PSYGENET The present findings suggest that the MTHFR C677T polymorphisms are likely to be associated with the risk of developing BD and schizophrenia and influence the age at onset of BD but not the age at onset of schizophrenia. 25101272 2014
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.600 Biomarker disease PSYGENET Functional deficiency, due to a common genetic variant of the methylenetetrahydrofolate reductase (NAD(P)H) (MTHFR) gene, could also affect the presentation of bipolar disorder. 23969624 2013
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.600 GeneticVariation disease BEFREE Functional deficiency, due to a common genetic variant of the methylenetetrahydrofolate reductase (NAD(P)H) (MTHFR) gene, could also affect the presentation of bipolar disorder. 23969624 2013
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.600 GeneticVariation disease BEFREE The random effect pooled OR was also significant and shows meager association between MTHFR C677T genotype and bipolar disorder. 21955385 2011
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.600 GeneticVariation disease BEFREE A single base variant in MTHFR gene (C677T) results in the production of a mildly dysfunctional thermolabile enzyme and has recently been implicated in BD. 20552676 2010
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.600 GeneticVariation disease BEFREE In conclusion, the MTHFR C677T variant is unlikely to play a major role in the susceptibility to bipolar disorder, although MTHFR plays an important role in the one-carbon metabolism and DNA methylation. 18983889 2009
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.600 GeneticVariation disease BEFREE Effect of the methylenetetrahydrofolate reductase gene polymorphisms on homocysteine, folate and vitamin B12 in patients with bipolar disorder and relatives. 18513846 2008
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.600 GeneticVariation disease BEFREE The present Scandinavian results do not verify previous associations between the putative functional MTHFR gene polymorphisms and schizophrenia or bipolar disorder. 18165967 2008
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.600 GeneticVariation disease LHGDN Effect of the methylenetetrahydrofolate reductase gene polymorphisms on homocysteine, folate and vitamin B12 in patients with bipolar disorder and relatives. 18513846 2008
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.600 Biomarker disease CTD_human The authors performed a meta-analysis of studies examining the association between polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, including MTHFR C677T and A1298C, and common psychiatric disorders, including unipolar depression, anxiety disorders, bipolar disorder, and schizophrenia. 17074966 2007
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.600 GeneticVariation disease LHGDN The authors performed a meta-analysis of studies examining the association between polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, including MTHFR C677T and A1298C, and common psychiatric disorders, including unipolar depression, anxiety disorders, bipolar disorder, and schizophrenia. 17074966 2007
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.600 GeneticVariation disease BEFREE Distribution of 1298A>C polymorphism of methylenetetrahydrofolate reductase gene in patients with bipolar disorder and schizophrenia. 17188847 2007
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.600 GeneticVariation disease BEFREE Association of 677C>T polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene with bipolar disorder and schizophrenia. 16545905 2006