Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
0.600 PosttranslationalModification disease BEFREE The current investigation aimed at analyzing the correlation between gut microbiome diversity and the methylation of the clock gene ARNTL in individuals with Bipolar Disorder (BD). 30465968 2019
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
0.600 Biomarker disease BEFREE Irregularity of the sleep-wake rhythm, eveningness chronotype, abnormality of melatonin secretion, vulnerability of clock genes, and the irregularity of social time cues have also been well-documented in BD. 29869403 2018
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
0.600 GeneticVariation disease BEFREE Is the molecular clock ticking differently in bipolar disorder? Methylation analysis of the clock gene ARNTL. 27739341 2018
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
0.600 Biomarker disease BEFREE It is proposed that BD with SP may be considered as a complex disorder resulting from the interaction of clock gene vulnerabilities and biological clock neuroplasticity, with environmental factors, such as the response to light. 29939763 2018
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
0.600 Biomarker disease BEFREE Based on the relationship between circadian clock genes pathway and BD/AAD we decided to test the connection of four core clock genes with common genetic background of both diseases. 30121446 2018
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
0.600 AlteredExpression disease BEFREE Lithium response in bipolar disorders and core clock genes expression. 28095742 2018
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
0.600 GeneticVariation disease BEFREE The relationship between these clock genes and DTI measures of WM integrity in a sample of 140 (53 M; 87 F) patients affected by BD type I was studied. 27996307 2017
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
0.600 Biomarker disease BEFREE Therefore, we conducted an analysis of the relationship between clock genes (as distal risk factors) with clinical characteristics and the course of bipolar disorder. 28837935 2017
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
0.600 Biomarker disease BEFREE Preliminary studies suggest that lithium (Li) response might be associated with some circadian gene polymorphisms, we therefore performed a pharmacogenetic study on the core clock genes in two independent samples suffering from bipolar disorder (BD) and thoroughly characterized for their Li response. 27324142 2016
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
0.600 GeneticVariation disease BEFREE Suicidal behavior in the context of disrupted rhythmicity in bipolar disorder--data from an association study of suicide attempts with clock genes. 25724486 2015
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
0.600 Biomarker disease PSYGENET Suicidal behavior in the context of disrupted rhythmicity in bipolar disorder--data from an association study of suicide attempts with clock genes. 25724486 2015
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
0.600 Biomarker disease PSYGENET Clock genes have been implicated in several disorders, such as schizophrenia, bipolar disorder, autism spectrum disorders, and drug dependence. 24865659 2014
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
0.600 Biomarker disease PSYGENET We genotyped 42 polymorphisms from circadian clock genes: PER3, ARNTL, CLOCK and TIMELSSS from 511 patients BD (n = 292 women and n = 219 men). 24673294 2014
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
0.600 Biomarker disease BEFREE Analysis of genetic association and epistasis interactions between circadian clock genes and symptom dimensions of bipolar affective disorder. 24673294 2014
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
0.600 Biomarker disease BEFREE Previously, we found correlations between lithium efficacy in bipolar disorder and temperamental dimensions of the TEMPS-A and also genes involved in the regulation of biological rhythms ("clock" genes). 24679394 2014
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
0.600 GeneticVariation disease BEFREE Since stressful life events or increased vulnerability to stress are risk factors for multiple psychiatric disorders, including post-traumatic stress disorder (PTSD), attention deficit hyperactivity disorder (ADHD), bipolar disorder (BD), major depressive disorder (MDD), alcohol use disorder (AUD) and schizophrenia (SCZ), we propose that modulation of the stress response is a common mechanism by which circadian clock genes affect these illnesses. 25135782 2014
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
0.600 Biomarker disease PSYGENET Polymorphism of circadian clock genes and temperamental dimensions of the TEMPS-A in bipolar disorder. 24679394 2014
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
0.600 Biomarker disease PSYGENET Since stressful life events or increased vulnerability to stress are risk factors for multiple psychiatric disorders, including post-traumatic stress disorder (PTSD), attention deficit hyperactivity disorder (ADHD), bipolar disorder (BD), major depressive disorder (MDD), alcohol use disorder (AUD) and schizophrenia (SCZ), we propose that modulation of the stress response is a common mechanism by which circadian clock genes affect these illnesses. 25135782 2014
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
0.600 Biomarker disease BEFREE Hence, the role of clock genes in BD and Li treatment remains unclear. 24150227 2013
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
0.600 GeneticVariation disease BEFREE Our analysis reveals previously unrecognized associations between clock genes and BD-spectrum illnesses, partly reconciling previously discordant results from past GWAS and candidate gene studies. 22384149 2012
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
0.600 GeneticVariation disease BEFREE The clock gene (CLOCK) is considered to be a good candidate gene for the pathophysiology of mood disorders, including bipolar disorder (BP) and major depressive disorder (MDD). rs1801260 (T3111C) has been detected at position 3111 in the CLOCK mRNA 3' untranslated region, and was reported to be associated with a substantial delay in preferred timing for activity and sleep in a human study. 22080789 2011
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
0.600 GeneticVariation disease BEFREE We determined genotype for 16 variants in seven circadian clock genes and conducted a candidate gene association study of these in 282 Caucasian patients with BD who were previously treated with lithium. 21781277 2011
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
0.600 GeneticVariation disease BEFREE Circadian clock gene Per3 variants influence the postpartum onset of bipolar disorder. 21316201 2011
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
0.600 Biomarker disease BEFREE This is the first time a clock gene is implicated in rapid cycling, and one of few findings showing a molecular discrimination between rapid cycling and other forms of bipolar disorder. 20856823 2010
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK
0.600 Biomarker disease BEFREE We previously reported work establishing mice lacking the clock gene D-box binding protein (DBP) as a stress-reactive genetic animal model of bipolar disorder. 19909500 2009