Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE A simple and fast method for the simultaneous detection of nine fibroblast growth factor receptor 3 mutations in bladder cancer and voided urine. 16278395 2005
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 Biomarker disease BEFREE Mutations in TERT promoter and FGFR3 and telomere length in bladder cancer. 25809917 2015
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE Several genetic changes may occur in bladder cancer, but activating mutations in the fibroblast growth factor receptor 3 (FGFR3) genes are the most common and most specific genetic abnormality in bladder cancer. 20822928 2013
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 Biomarker disease BEFREE In contrast, there are very few studies on the impact of miRNA regulation on signaling by VHL (von Hippel-Lindau tumor suppressor) and vascular endothelial growth factor in renal cell carcinoma or by fibroblast growth factor receptor 3 and p53 in bladder cancer. 21632885 2011
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE PATIENT SUMMARY: We propose that APOBEC-mediated mutagenesis can generate clinically relevant driver mutations even within suboptimal motifs, such as in the case of FGFR3 S249C, one of the most common mutations in bladder cancer. 30975452 2019
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE The GSE41035 dataset downloaded from Gene Expression Omnibus was used to identify the differentially expressed genes (DEGs) between bladder cancer cell line RT112 with or without depletion of FGFR3, and gene ontology enrichment analysis was performed. 28320388 2017
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 Biomarker disease BEFREE Our findings of this new link between p53 family proteins and FGFR3 may help understanding the transition of superficial bladder cancers to an invasive phenotype. 20298673 2010
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE Our results show a link between germline variants, somatic mutations of FGFR3 and risk of UBC. 20348956 2010
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 Biomarker disease BEFREE Regarding the association between mutated FGFR3 and bladder cancer, we found an OR 31 95% CI (15-64). 31028457 2019
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE TP53 and FGFR3 Gene Mutation Assessment in Urine: Pilot Study for Bladder Cancer Diagnosis. 26254388 2015
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE An example of a TM domain pathogenic mutation is the Ala391-->Glu mutation in fibroblast growth factor receptor 3 (FGFR3), linked to Crouzon syndrome with acanthosis nigricans, as well as to bladder cancer. 16384584 2006
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE Incidence of fibroblast growth factor receptor 3 gene (FGFR3) A248C, S249C, G372C, and T375C mutations in bladder cancer. 21264819 2011
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 AlteredExpression disease BEFREE Bladder cancer cell lines were exposed to normoxic or hypoxic conditions and examined for the expression of FGFR3 by quantitative PCR (qPCR) and western blotting, and miR-100 by qPCR. 23778527 2013
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 Biomarker disease BEFREE MMP-1 and MMP-10 mRNA and protein were downmodulated by FGFR3 shRNA and R3Mab in bladder cancer cell lines. 25326231 2014
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 Biomarker disease BEFREE Human bladder cancer T24 and 5637 cell lines were transiently transfected with FGFR3-AS1-specific siRNA or negative control siRNA. 29226855 2018
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE Silencing or inhibition of mutant FGFR3 in bladder cancer cell lines is associated with decreased malignant potential, confirming its important driver role in UC. 30952872 2019
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 Biomarker disease BEFREE FGFR3-TACC3 fusion transcripts were identified by RNA-FISH and RT-PCR in mouse xenograft FFPE tissues using the human BC cell lines RT112 and RT4. 27930669 2016
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE The two most important developments are the identification of a mutation in the fibroblast growth factor receptor 3 gene in more than 50% of urothelial carcinomas and the discovery of cDNA profiles characteristic of different subsets of bladder cancer. 19031931 2009
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 AlteredExpression disease BEFREE FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer. 17668422 2007
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 AlteredExpression disease BEFREE Further investigation showed that FGFR3 knockdown resulted in downregulation of DAPK1 in bladder cancer cell line, suggesting that FGFR3 may be an upstream factor of DAPK1. 28388658 2017
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE 1-tert-butyl-3-[6-(3,5-dimethoxy-phenyl)-2-(4-diethylamino-butylamino)-pyrido[2,3-d]pyrimidin-7-yl]-urea (PD173074), a selective tyrosine kinase inhibitor of fibroblast growth factor receptor-3 (FGFR3), inhibits cell proliferation of bladder cancer carrying the FGFR3 gene mutation along with up-regulation of p27/Kip1 and G1/G0 arrest. 19955487 2010
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE FGFR3 analyses did not reveal any mutation in the urothelium from neither the control group nor the bladder cancer group. 19621447 2009
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE The Diagnostic and Prognostic Performance of Urinary FGFR3 Mutation Analysis in Bladder Cancer Surveillance: A Prospective Multicenter Study. 26364695 2015
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE FGFR3 and Tp53 mutations have been proposed as defining two alternative pathways in the pathogenesis of transitional bladder cancer. 16061860 2005
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE We carried out a meta-analysis of published findings for FGFR3 and TP53 mutations in bladder cancer (535 tumours, 6 publications) and additional unpublished data for 382 tumours. 23272046 2012