Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 Biomarker disease BEFREE Fibroblast growth factor receptor 3 (FGFR3) is an actionable target in bladder cancer. 27091807 2016
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE Analysing only previously reported point mutations, TERT mutations were found in 55% of patients with bladder cancer (independent of stage), FGFR3 mutations in 30% of patients with bladder cancer, PIK3CA in 14% and TP53 mutations in 12% of patients with bladder cancer. 26901314 2016
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE We assessed the performance of associating a FGFR3 mutation assay and a DNA methylation analysis to improve bladder cancer detection and to predict disease recurrence of NMIBC patients. 27586786 2016
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 Biomarker disease BEFREE Mutations in TERT promoter and FGFR3 and telomere length in bladder cancer. 25809917 2015
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE TP53 and FGFR3 Gene Mutation Assessment in Urine: Pilot Study for Bladder Cancer Diagnosis. 26254388 2015
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE The Diagnostic and Prognostic Performance of Urinary FGFR3 Mutation Analysis in Bladder Cancer Surveillance: A Prospective Multicenter Study. 26364695 2015
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE Recent developments in the field of molecular mutational pathway analyses based on next generation sequencing technology together with classic data derived from the description of mutations in the FGFR3 (fibroblast growth factor receptor 3) gene, mutations on TP53 gene, and cDNA technology profiling data gives support to a differentiated taxonomy of bladder cancer. 25654736 2015
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 Biomarker disease BEFREE This is a comprehensive genomic characterization of 40 urothelial bladder carcinoma (UBC) cell lines including information on origin, mutation status of genes implicated in bladder cancer (FGFR3, PIK3CA, TP53, and RAS), copy number alterations assessed using high density SNP arrays, uniparental disomy (UPD) events, and gene expression. 25997541 2015
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE When we examined detailed data on a prevalent occupational exposure associated with increased bladder cancer risk, straight metalworking fluids, we also observed statistically significant additive interaction for rs798766 (TMEM129-TACC3-FGFR3, P interaction = .02), with the interaction more apparent in patients with tumors positive for FGFR3 expression.All statistical tests were two-sided. 26374428 2015
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 Biomarker disease BEFREE TERT promoter mutations and TERT mRNA but not FGFR3 mutations are urinary biomarkers in Han Chinese patients with urothelial bladder cancer. 25657201 2015
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE Activating mutations of FGFR3 are a common and early event in bladder cancer. 25223521 2015
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE The aim of this review was to overview the outcomes of different mutations in FGFR3 receptor in the context of BC. 26542242 2015
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 Biomarker disease BEFREE Activating point mutations and protein overexpression of fibroblast growth factor receptors (FGFRs), especially FGFR3, are frequent events in bladder cancer. 24898159 2015
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 Biomarker disease BEFREE MMP-1 and MMP-10 mRNA and protein were downmodulated by FGFR3 shRNA and R3Mab in bladder cancer cell lines. 25326231 2014
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 Biomarker disease BEFREE FGFR3 translocations in bladder cancer: differential sensitivity to HSP90 inhibition based on drug metabolism. 24784839 2014
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 Biomarker disease BEFREE The development and progression of BC rely on a very complex signaling network that involves many different receptors aside from FGFR3 and VEGFR2. 25284004 2014
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE This study demonstrated that FGFR3 mutations are closely related to low grade, early stage, and better survival among bladder cancer patients. 24634132 2014
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 AlteredExpression disease BEFREE Conversely, FGFR3 over-expression was recently found in 40 % of muscle invasive BC. 24880661 2014
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE We further demonstrate that activating mutations in FGFR3 associated with both multiple myeloma and bladder cancer can modulate expression of genes that regulate NFκB signaling, and promote both NFκB transcriptional activity and cell adhesion in a manner dependent on TAK1 expression in both cancer cell types. 24466111 2014
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE Several genetic changes may occur in bladder cancer, but activating mutations in the fibroblast growth factor receptor 3 (FGFR3) genes are the most common and most specific genetic abnormality in bladder cancer. 20822928 2013
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 AlteredExpression disease BEFREE Bladder cancer cell lines were exposed to normoxic or hypoxic conditions and examined for the expression of FGFR3 by quantitative PCR (qPCR) and western blotting, and miR-100 by qPCR. 23778527 2013
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 Biomarker disease BEFREE Two bladder cancer cell lines that harbor FGFR3 fusion proteins exhibited enhanced susceptibility to pharmacologic inhibition in vitro and in vivo. 23558953 2013
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 Biomarker disease CTD_human Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation. 24121792 2013
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 AlteredExpression disease BEFREE Sensitivity to the growth-inhibitory effects of BGJ-398 was also restricted to the "epithelial" BC cells and it correlated directly with FGFR3 mRNA levels but not with the presence of activating FGFR3 mutations. 23468956 2013
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.800 GeneticVariation disease BEFREE Oncogenic FGFR3 gene fusions in bladder cancer. 23175443 2013