Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.600 Biomarker disease CTD_human Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors. 27111033 2016
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.600 GeneticVariation disease BEFREE For ERCC2 Lys751Gln, individuals who carried the variant heterozygote Lys/Gln or homozygote Gln/Gln had a significantly increased bladder cancer risk, compared with the wild genotype Lys/Lys (OR=1.10, 95 % CI=1.03-1.18). 24504678 2014
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.600 GeneticVariation disease BEFREE Xeroderma pigmentosum complementation group D (XPD) gene polymorphisms contribute to bladder cancer risk: a meta-analysis. 24347488 2014
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.600 GeneticVariation disease BEFREE The current meta-analysis indicated that the Lys751Gln polymorphism in the XPD gene might be a risk factor for bladder cancer. 24535265 2014
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.600 GeneticVariation disease BEFREE Among four DNA repair gene polymorphisms, the OGG1 326 Ser/Cys and XPD 312 Asp/Asn heterozygous genotypes might be recognized as potential genetic markers modifying susceptibility to bladder cancer in Belarus. 25089939 2014
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.600 Biomarker disease CTD_human Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy. 24121791 2013
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.600 GeneticVariation disease BEFREE These associations were: two SNPs rs1799793 and rs13181 in the ERCC2 gene and lung cancer (recessive model) and rs1805794 in the NBN gene and bladder cancer (dominant model). 21864546 2012
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.600 GeneticVariation disease BEFREE When we investigated the effect of genetic polymorphisms in bladder cancer development we have found that ERCC2 and ERCC5 variants were not implicated in the bladder cancer occurrence. 21426550 2011
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.600 GeneticVariation disease BEFREE We have conducted a case-control study to assess the role of smoking, slow NAT2 variants, GSTM1 and GSTT1 null, and XPC, XPD, XPG nucleotide excision-repair (NER) genotypes in bladder cancer development in North Tunisia. 21647780 2011
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.600 GeneticVariation disease BEFREE Impact of nucleotide excision repair ERCC2 and base excision repair APEX1 genes polymorphism and its association with recurrence after adjuvant BCG immunotherapy in bladder cancer patients of North India. 19242824 2010
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.600 GeneticVariation disease BEFREE This meta-analysis suggested that the XPD Asp312Asn but not Lys751Gln polymorphism may be more genetically susceptible to bladder cancer development. 19492231 2009
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.600 GeneticVariation disease BEFREE Subtle but significant cancer risk was observed for the XPD Asp 312 Asn polymorphism in bladder cancer (for Asp/Asn versus Asp/Asp: OR, 1.24; 95% CI, 1.06-1.46). 18349268 2008
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.600 GeneticVariation disease BEFREE The aim of the study was to investigate NAT1, NAT2, GSTM1, GSTT1, GSTP1, SULT1A1, XRCC1, XRCC3 and XPD genetic polymorphisms, coffee consumption and risk of bladder cancer (BC) through a hospital-based case-control study. 18365755 2008
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.600 GeneticVariation disease BEFREE In multifactor dimensionality reduction (MDR) analysis, the five-factor model including smoking, CCNH V270A, ERCC6 M1097V, RAD23B A249V and XPD D312N had the best ability to predict bladder cancer risk. 17728339 2007
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.600 GeneticVariation disease BEFREE These two XPD polymorphisms may play an important role in the etiology of bladder cancer in the southeastern Chinese population. 17693188 2007
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.600 GeneticVariation disease BEFREE We investigated if the presence of single nucleotide polymorphisms (SNPs) in the XRCC1, XRCC3, and XPD genes were associated with the type and frequency of p53 mutations in bladder cancer. 16652373 2006
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.600 Biomarker disease BEFREE Interpretation of this multifactor model revealed that the relationship between the XPD SNPs and bladder cancer is mostly non-additive while the effect of smoking is mostly additive. 16311243 2006
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.600 GeneticVariation disease BEFREE We evaluated the influence of common genetic variation in the NER pathway on bladder cancer risk by analyzing 22 single nucleotide polymorphisms (SNP) in seven NER genes (XPC, RAD23B, ERCC1, ERCC2, ERCC4, ERCC5, and ERCC6). 16537713 2006
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.600 GeneticVariation disease BEFREE The XPD polymorphism was not, however, associated with bladder cancer risk. 14652287 2003
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.600 GeneticVariation disease BEFREE We also hypothesized that allelic variants of the NAT1 and NAT2 genes might modify the effect of the XPD codon 751 polymorphism on smoking-associated bladder-cancer risk. 12376500 2002
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.600 Biomarker disease BEFREE XPD and XRCC1 appear to have no impact on the risk of bladder cancer. 11304692 2001
Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
0.600 CausalMutation disease CGI