Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 GeneticVariation disease BEFREE Moreover we detect TERT promotor mutation status in the recurrent tumors (n = 21) of these UBC patients. 31521529 2020
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 Biomarker disease BEFREE The aRNA driven by a tumor-specific mutant human telomerase reverse transcriptase (hTERT) promoter is created to interact with iRNA to expose UAS again in bladder cancer. 29084575 2017
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 Biomarker disease BEFREE FGFR3, TERT and OTX1 as a Urinary Biomarker Combination for Surveillance of Patients with Bladder Cancer in a Large Prospective Multicenter Study. 28049011 2017
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 GeneticVariation disease BEFREE Analysing only previously reported point mutations, TERT mutations were found in 55% of patients with bladder cancer (independent of stage), FGFR3 mutations in 30% of patients with bladder cancer, PIK3CA in 14% and TP53 mutations in 12% of patients with bladder cancer. 26901314 2016
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 Biomarker disease BEFREE In our study, we aimed to construct a synthetic combination module driven by a super artificial hTERT promoter and to investigate its influence on the malignant phenotypes of bladder cancer. 26743236 2016
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 GeneticVariation disease BEFREE Two recurrent point mutations in the promoter region of telomerase reverse transcriptase (TERT)--the key subunit of telomerase--have recently been identified in melanoma as well as a small sample of bladder cancer cell lines. 27040924 2016
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 Biomarker disease BEFREE The detection of TERT-mut in urine is under investigation as a potential urine-based molecular-screening assay for bladder cancer. 26965579 2016
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 Biomarker disease BEFREE Similar to urothelial carcinoma, we found a relatively higher rate of TERT-mut among nonenteric-type adenocarcinomas further supporting the potential utility of TERT-mut urine-based screening assay for bladder cancer. 26980028 2016
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 GeneticVariation disease BEFREE Recently, recurrent mutations within the core promoter of the human telomerase reverse transcriptase (TERT) gene generating consensus binding sites for ETS transcription factor family members were described in melanomas and other malignancies (e.g. bladder cancer, hepatocellular carcinoma). 25997473 2015
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 AlteredExpression disease BEFREE TERT expression levels are consistent with clinical severity and prognosis of bladder cancer. 26143634 2015
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 Biomarker disease BEFREE TERT promoter mutations and TERT mRNA but not FGFR3 mutations are urinary biomarkers in Han Chinese patients with urothelial bladder cancer. 25657201 2015
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 GeneticVariation disease BEFREE Genetic analysis of bladder cancer has revealed a number of frequently altered genes, including frequent alterations of the telomerase (TERT) gene promoter, although few altered genes have been functionally evaluated. 25225064 2014
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 GeneticVariation disease BEFREE Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome. 24018021 2014
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 GeneticVariation disease BEFREE Recently, mutations in telomerase (TERT) gene promoter were found in sporadic and familial melanoma and subsequently in several cancer models, notably in gliomas, thyroid cancer and bladder cancer. 25048572 2014
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 GeneticVariation disease BEFREE Further clinical confounding factor, namely, tumor grade/stage level of cases, supports the genotypic data with TERT and SLC14A1 showing a risk for BC susceptibility. 25218484 2014
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 GeneticVariation disease BEFREE Recently, single nucleotide polymorphisms in the region of the human telomerase reverse transcriptase (hTERT) gene were associated with various malignancies, including glioma, lung and urinary bladder cancer, and telomerase RNA gene hTERC genotypes were recently linked to TL. 22539396 2012
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 Biomarker disease BEFREE Correlation of TRAP and hTERT protein with MIB1 and p53 reveals the importance of telomerase as a new marker in cancer bladder. 20934419 2011
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 Biomarker disease CTD_human Sequence variants at the TERT-CLPTM1L locus associate with many cancer types. 19151717 2009
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 AlteredExpression disease BEFREE Real-time quantitative analysis for human telomerase reverse transcriptase mRNA and human telomerase RNA component mRNA expressions as markers for clinicopathologic parameters in urinary bladder cancer. 16734859 2006
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 Biomarker disease BEFREE Here we evaluated combination therapy of adenoviral vector Ad-hTERT-CD encoding E. coli cytosine deaminase (CD) driven by the hTERT promoter and low-dose etoposide (0.1 microg/mL) for treating bladder cancer. 17047058 2006
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 Biomarker disease BEFREE This suggests that the hTERT gene might be a suitable gene target for bladder cancer therapy. 16153224 2005
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 AlteredExpression disease BEFREE A prospective evaluation of the diagnostic and potential prognostic utility of urinary human telomerase reverse transcriptase mRNA in patients with bladder cancer. 15636669 2004
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 Biomarker disease BEFREE Methylation of DAPK, BCL2, and TERT in urine sediment DNA from bladder cancer patients was detected in the majority of samples (78%), whereas they were unmethylated in the urine sediment DNA from age-matched cancer-free individuals. 15569975 2004
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 AlteredExpression disease BEFREE Detection of human telomerase reverse transcriptase mRNA in urine of patients with bladder cancer: evaluation of an emerging tumor marker. 12893365 2003
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.400 AlteredExpression disease BEFREE These findings indicate that the up-regulation of hEST2/hTRT gene expression may play a critical role in carcinogenesis of human urinary bladder cancers. 10569622 1999