Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | AlteredExpression | disease | BEFREE | CRISPR/Cas9-mediated deletion of the enhancer region reduced the viability of bladder cancer cells by decreasing the expression of ΔNTP63 and p63 target genes. | 29956121 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | Bladder cancer (BC) ranks as the sixth most common cancer in the United States and is the leading cause of death in patients with urinary malignancies. p63 is a member of the p53 family and is believed to function as a tumor suppressor in human BCs. | 30104251 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | However, it remains unclear whether and how p63 functions in BC cell invasion after tumorigenesis. | 28794159 | 2017 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | The p63 and p73 expressions have been investigated in a variety of human tumours including bladder carcinomas; yet, this is the first study to simultaneously analyse the transcriptional levels of all p53 family members in bladder cancer. | 24213852 | 2014 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | We used real-time PCR to characterize p63 expression and several genes implicated in epithelial-to-mesenchymal transition (EMT) in human bladder cancer cell lines (n = 15) and primary tumors (n = 101). | 22253920 | 2012 | ||||
|
0.080 | Biomarker | disease | BEFREE | Together, our results implicate p63 and its downstream target c-myc as determinants of sensitivity to anti-mitotics in bladder cancer cells. | 22361733 | 2012 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Loss of p63 expression is associated with tumor progression in bladder cancer. | 12368193 | 2002 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Our data suggest that altered expression of p63 is a frequent event in bladder carcinogenesis and might contribute to the progression of bladder tumors, possibly via the mechanism(s) distinct from the p53 pathway. | 10910040 | 2000 |