Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
0.400 Biomarker disease BEFREE Our study uncovers a novel molecular mechanism for regulating <i>pd-l1</i> mRNA stability and expression via ATG7/autophagy/FOXO3A/miR-145 axis and reveals the potential for using combination treatment with autophagy inhibitors and PD-1/PD-L1 immune checkpoint blockade to enhance therapeutic efficacy for human BCs. 30871066 2019
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
0.400 Biomarker disease BEFREE CircCEP128 and MYD88 were overexpressed in bladder cancer based on microarray analysis and miR-145-5p was a potential targeting factor in bladder cancer. 30939216 2019
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
0.400 Biomarker disease BEFREE Celecoxib inhibits the epithelial-to-mesenchymal transition in bladder cancer via the miRNA-145/TGFBR2/Smad3 axis. 31198976 2019
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
0.400 AlteredExpression disease BEFREE Circ_0058063 acted as a sponge of miR-145-5p to promote BC progression by regulating CDK6 expression, which provided some potential targets for BC treatment. 30362519 2019
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
0.400 AlteredExpression disease BEFREE KCNQ1OT1 serves as competing endogenous RNA (ceRNA) to up-regulate PCBP2 via sponging miR-145-5p in BC progression. 31827399 2019
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
0.400 Biomarker disease BEFREE Further prognostic analysis showed that circRNA interacted miRNA hsa-miR-106b, hsa-miR-145 and hsa-miR-214 were associated with overall survival in patients with bladder cancer (P < 0.05). 31169020 2019
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
0.400 Biomarker disease BEFREE In addition, the high expression of TAGLN2 promoted cell proliferation and migration in BC. miR-145-5p appeared to regulate TAGLN2 in BC, and it also inhibited the cell proliferation and migration. 30405771 2018
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
0.400 Biomarker disease BEFREE The results of the present study indicated that miRNA‑145 may function as a tumor suppressor and may have a potential to be a diagnostic and predictive biomarker, and a therapeutic target for treatment of BC. 29693148 2018
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
0.400 Biomarker disease BEFREE Circular RNA CEP128 acts as a sponge of miR-145-5p in promoting the bladder cancer progression via regulating SOX11. 30134837 2018
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
0.400 Biomarker disease CTD_human A Panel of MicroRNA Signature as a Tool for Predicting Survival of Patients with Urothelial Carcinoma of the Bladder. 30026881 2018
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
0.400 Biomarker disease BEFREE TGFβ1 Promotes Gemcitabine Resistance through Regulating the LncRNA-LET/NF90/miR-145 Signaling Axis in Bladder Cancer. 28839463 2017
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
0.400 Biomarker disease BEFREE A Novel Combination RNAi toward Warburg Effect by Replacement with miR-145 and Silencing of PTBP1 Induces Apoptotic Cell Death in Bladder Cancer Cells. 28106737 2017
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
0.400 AlteredExpression disease BEFREE Here, we found that miR-145 was upregulated in human patients with bladder cancer with lymph node metastasis and in metastatic T24T cell line. 28223425 2017
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
0.400 AlteredExpression disease BEFREE Luciferase assay results showed that miR-145 directly bound to 3'UTR of KLF4, which was shown to be overexpressed in the clinical BC samples using Western blot analysis and immunohistochemistry. 28380435 2017
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
0.400 Biomarker disease BEFREE The aim of the present study was to investigate the functional significance of miR-145-3p and BC oncogenic pathways and targets regulated by miR-145-5p/miR-145-3p. 27072587 2016
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
0.400 AlteredExpression disease BEFREE Furthermore, we also observed a positive correlation between lncRNA-UCA1 and ZEB1/2 expression, and a negative correlation between lncRNA-UCA1 and hsa-miR-145 expression in bladder cancer specimens. 26544536 2016
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
0.400 Biomarker disease BEFREE Micro-RNA analyses of BC tissue revealed that miR-145 and miR-29c* function as tumor suppressors, whereas miR-183 and miR-17-5p function as oncogenic miRNAs. 26924873 2016
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
0.400 AlteredExpression disease BEFREE The expression levels of both miR-143 and miR-145 were significantly decreased, whereas those of miR-224 were increased in BlCa. 25804644 2015
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
0.400 AlteredExpression disease BEFREE By using transwell invasion assay and western blotting analysis, we investigated the effects of miR-145 and PAK1 on bladder cancer cell invasion and expression of invasion marker genes. 24954107 2014
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
0.400 Biomarker disease BEFREE Taken together, our data suggest that miR-145 may inhibit bladder cancer initiation by affecting IGF-IR signaling. 24999188 2014
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
0.400 AlteredExpression disease BEFREE Expression profile of microrna-145 in urothelial bladder cancer. 23489501 2013
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
0.400 AlteredExpression disease BEFREE Several studies have demonstrated the potential of miRNAs for providing prognostic information. miR-145 is the most frequently downregulated miRNA in bladder cancer and has been shown to significantly inhibit proliferation, migration and invasion. 23712207 2013
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
0.400 AlteredExpression disease BEFREE miR-10b, 19a, 126, 145, 221, 296-5p and 378 were significantly down-regulated in bladder cancer compared to adjacent normal urothelium. miR-145 was the most down-regulated microRNA of this group. miR-19b, 21, 205 and 210 showed no significant difference between the 2 tissue types. 22704449 2012
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
0.400 Biomarker disease BEFREE We also demonstrate mRNA co-targeting by a cluster of non-family miRNAs, and suggest miR-145 and PAI-1 as clinically relevant biomarkers in bladder cancer. 22108519 2012
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
0.400 AlteredExpression disease BEFREE The aim of this study is to determine the genes targeted by miR-145, which is the most down-regulated microRNA in BC. 20160723 2010