| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.370 | AlteredExpression | disease | BEFREE | Our data from bioinformatic and luciferase reporter gene assays identified that miR-5195-3p targeted the mRNA 3'-UTR of Krüppel-like factor 5 (KLF5), which is a proven proto-oncogene in bladder cancer. miR-5195-3p sharply reduced KLF5 expression and suppressed the expression or activation of its several downstream genes that are kinases improving cell survival or promoting cell cycle regulators, including ERK1/2, VEGFA, and cyclin D1. | 28109084 | 2017 | ||||
|
0.370 | Biomarker | disease | BEFREE | We propose the KLF5/FYN/p-FAK axis as a potential therapeutic target in bladder cancer. | 26786295 | 2016 | ||||
|
0.370 | Biomarker | disease | BEFREE | Transcription Factor KLF5 Binds a Cyclin E1 Polymorphic Intronic Enhancer to Confer Increased Bladder Cancer Risk. | 27514407 | 2016 | ||||
|
0.370 | Biomarker | disease | CTD_human | Transcription Factor KLF5 Binds a Cyclin E1 Polymorphic Intronic Enhancer to Confer Increased Bladder Cancer Risk. | 27514407 | 2016 | ||||
|
0.370 | Biomarker | disease | BEFREE | Taken together, our results indicate that KLF5 promotes angiogenesis of bladder cancer through directly regulating VEGFA transcription and suggest that KLF5 could be a novel therapeutic target for angiogenesis inhibition in bladder cancer. | 26544730 | 2015 | ||||
|
0.370 | Biomarker | disease | BEFREE | Thus, our data indicates that curcumin promotes KLF5 proteasome-dependent degradation through targeting YAP/TAZ in bladder cancer cells and also suggests the therapeutic potential of curcumin in the treatment of bladder cancer. | 25170806 | 2014 | ||||
|
0.370 | AlteredExpression | disease | BEFREE | These findings suggest that the KLF5 transcription factor plays an oncogenic role in the TSU-Pr1 bladder cancer cell line through the regulation of a subset of genes. | 16184550 | 2006 | ||||
|
0.370 | AlteredExpression | disease | LHGDN | We then transduced the KLF4 and KLF5 genes into the bladder cancer cell lines using adenoviral vectors to examine the biological activities of the genes on those cells. | 12901861 | 2003 | ||||
|
0.370 | Biomarker | disease | BEFREE | We then transduced the KLF4 and KLF5 genes into the bladder cancer cell lines using adenoviral vectors to examine the biological activities of the genes on those cells. | 12901861 | 2003 |