| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | To the best of our knowledge, this is the first report of CML-BC with inv(16) and P190 BCR/ABL. | 21523337 | 2011 | ||||
|
0.080 | Biomarker | disease | BEFREE | After treatment with imatinib, the p210 transcript could not be detected, whereas p190 was still present 6 months after initiation of imatinib therapy and progression to blast phase. | 15949566 | 2005 | ||||
|
0.080 | Biomarker | disease | BEFREE | We present here a rare case of Philadelphia chromosome (Ph)-positive chronic myelogenous leukemia having p190 BCR/ABL with a malignant clinical picture of extramedullary blast crisis at onset, followed by rapid evolution to bone-marrow blast crisis. | 9530344 | 1998 | ||||
|
0.080 | Biomarker | disease | BEFREE | The median ratio of p190 to p210 BCR-ABL mRNA was not significantly different between chronic phase CML (1.9 x 10(-4)) and CML in blast crisis (1.7 x 10(-4)). | 8652835 | 1996 | ||||
|
0.080 | Biomarker | disease | BEFREE | To investigate the hypothesis that the production of P190 may be associated with the progression from chronic phase to blast crisis in CML, we used polymerase chain reaction to analyze blood from 37 patients with accelerated phase/blast crisis CML for the transcripts coding for the P210BCR-ABL and P190BCR-ABL. | 2013978 | 1991 | ||||
|
0.080 | Biomarker | disease | BEFREE | The shorter p190 protein is associated almost only with ALL and AML, while the protein p210 is present in both chronic phase and blast crisis of CML and also in 50% of Philadelphia-positive (Ph1+) ALL. | 2247753 | 1990 | ||||
|
0.080 | Biomarker | disease | BEFREE | We conclude that the acquisition of the p190 does not play a significant role in the generation of the blast crisis of CML. | 2223646 | 1990 | ||||
|
0.080 | PosttranslationalModification | disease | BEFREE | In addition to the previously reported P210 and P190 abl-related proteins, a novel Mr 53,000 protein was found to undergo phosphorylation at serine and tyrosine in immune complex kinase assays of two blast crisis CML cell lines (K562 and EM2) and in samples from blast crisis patients in which P210bcr-abl was detected. | 2434223 | 1987 |