This suggests that interleukins such as IL-6 and IL-10 have a close association with coagulopathy and fibrinolytic dysregulation in sepsis and can be considered as candidates for potential therapeutic targets in SAC.
In the seven children who developed shock with NPMODS compared to eight patients with shock without NPMODS and 12 patients with severe sepsis only, we found more profound coagulopathy [thrombocytopenia (<i>p</i> = 0.04), elevated INR (<i>p</i> = 0.038), low fibrinogen level (<i>p</i> = 0.049), and low TEG-G value (<i>p</i> = 0.01)] and higher peak of interleukin-6 (<i>p</i> = 0.0014) and IL-10 (<i>p</i> = 0.007).