Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1 		0.310 Biomarker group CTD_human Human TGF-β1 deficiency causes severe inflammatory bowel disease and encephalopathy. 29483653 2018
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1 		0.310 Biomarker group BEFREE Involvement of TGF-beta 1 in these human brain disorders is discussed in relation to the potent effects of TGF-beta 1 on wound healing and inflammatory responses in peripheral tissues. 8300749 1993
Entrez Id: 8851
Gene Symbol: CDK5R1
CDK5R1 		0.310 Biomarker group BEFREE Malfunctioning of cyclin-dependent kinase 5 (CDK5) through aberrant proteolytic cleavage of its neuronal activators p35 and p39 is involved in neurodegeneration in Alzheimer's disease (AD) and other neurodegenerative brain diseases. 15917097 2005
Entrez Id: 11277
Gene Symbol: TREX1
TREX1 		0.310 Biomarker group CTD_human Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus. 16845398 2006
Entrez Id: 7248
Gene Symbol: TSC1
TSC1 		0.310 Biomarker group CTD_human Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex. 21062901 2011
Entrez Id: 8851
Gene Symbol: CDK5R1
CDK5R1 		0.310 Biomarker group CTD_human Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling. 15665076 2005
Entrez Id: 11277
Gene Symbol: TREX1
TREX1 		0.310 GeneticVariation group BEFREE Mutations in the TREX1 gene are an underlying cause of the neurological brain disease Aicardi-Goutières syndrome implicating TREX1 dysfunction in an aberrant immune response. 17293595 2007
Entrez Id: 351
Gene Symbol: APP
APP 		0.310 Biomarker group CTD_human However, when stained with beta-amyloid precursor protein, multifocal axonal injury was evident in the brain, spinal cord, and nerve roots. 11800653 2002
Entrez Id: 3458
Gene Symbol: IFNG
IFNG 		0.310 AlteredExpression group BEFREE This mechanism might contribute to cognitive impairment in chronic brain disease featuring elevated IFN-γ levels, blood-brain barrier leakage, and/or T cell infiltration, well before neurodegeneration occurs. 30782788 2019
Entrez Id: 7248
Gene Symbol: TSC1
TSC1 		0.310 Biomarker group LHGDN These results indicate that hamartin binds to NADE to regulate neuronal cell function and loss of this association is likely to contribute to the brain pathology in TSC. 17355907 2007
Entrez Id: 351
Gene Symbol: APP
APP 		0.310 Biomarker group BEFREE Amyloid-β precursor protein (APP) correlates with the pathogenesis of certain brain diseases, such as Alzheimer disease (AD). 29777707 2018
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1 		0.310 Biomarker group BEFREE Interferon beta (IFNbeta) has been shown to decrease clinical relapses, reduce brain disease activity, and possibly slow progression of disability. 12618863 2003
Entrez Id: 3458
Gene Symbol: IFNG
IFNG 		0.310 Therapeutic group CTD_human Protective effects of interferon-gamma against methamphetamine-induced neurotoxicity. 18282668 2008
Entrez Id: 3456
Gene Symbol: IFNB1
IFNB1 		0.310 Biomarker group CTD_human In vitro assessment for neurotoxicity of antitumor agents before local administration into central nervous system. 8615598 1996
Entrez Id: 10617
Gene Symbol: STAMBP
STAMBP 		0.300 Biomarker group CTD_human Mutations in STAMBP, encoding a deubiquitinating enzyme, cause microcephaly-capillary malformation syndrome. 23542699 2013
Entrez Id: 213
Gene Symbol: ALB
ALB 		0.300 Biomarker group CTD_human Evaluating risk factors for the development of ifosfamide encephalopathy. 15923801 2005
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6 		0.300 Biomarker group CTD_human CYP2A6 plays a key role in nicotine metabolism and oxidative stress in astrocytes, and this has implications in nicotine-associated brain toxicity. 22498344 2012
Entrez Id: 6505
Gene Symbol: SLC1A1
SLC1A1 		0.300 Biomarker group CTD_human Taken together, this study implicates EAAC1-dependent cysteine uptake as an endogenous source of enhancing antioxidant function and zinc homeostasis in neurons in the ischemic brain. 22575539 2012
Entrez Id: 5009
Gene Symbol: OTC
OTC 		0.300 Biomarker group CTD_human Long-term treatment of girls with ornithine transcarbamylase deficiency. 8778603 1996
Entrez Id: 4353
Gene Symbol: MPO
MPO 		0.300 Biomarker group CTD_human Resveratrol confers protection against rotenone-induced neurotoxicity by modulating myeloperoxidase levels in glial cells. 23593274 2013
Entrez Id: 7054
Gene Symbol: TH
TH 		0.300 Therapeutic group CTD_human Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain. 7842013 1994
Entrez Id: 3785
Gene Symbol: KCNQ2
KCNQ2 		0.300 Biomarker group CTD_human KCNQ2 encephalopathy: Features, mutational hot spots, and ezogabine treatment of 11 patients. 27602407 2016
Entrez Id: 8635
Gene Symbol: RNASET2
RNASET2 		0.300 Biomarker group CTD_human Congenital cytomegalovirus infection and RNASET2 deficiency may both interfere with brain development and myelination through angiogenesis or RNA metabolism. 19525954 2009
Entrez Id: 1356
Gene Symbol: CP
CP 		0.300 Biomarker group CTD_human Results also indicate that ceruloplasmin interacted with chronic elevated manganese exposures to produce greater levels of brain oxidative stress. 19005224 2009
Entrez Id: 7249
Gene Symbol: TSC2
TSC2 		0.300 Biomarker group CTD_human Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex. 21062901 2011