Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 CausalMutation group CGI
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 GeneticVariation group BEFREE Future clinical trials should address whether BRAF (V600E) mutant brain tumor patients will benefit from BRAF (V600E)-directed targeted therapies. 21274720 2011
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 GeneticVariation group BEFREE BRAF mutations constitute a major genetic alteration in this histologic group of pediatric brain tumors and may serve as a molecular target for biologically based inhibitors. 20156809 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 GeneticVariation group CLINVAR Targeted therapy for BRAFV600E malignant astrocytoma. 22038996 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 GeneticVariation group CLINVAR Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy. 22586120 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 GeneticVariation group BEFREE Recently, aberrant methylation of MLH1, MGMT and MSI were shown to be associated with mutations in genes such as BRAF, RAS and IDH1 in colon and brain tumours. 23414134 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 GeneticVariation group BEFREE An activating mutation of BRAF (BRAF-V600E) has been reported in a subset of malignant brain tumors. 24721513 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 Biomarker group BEFREE The use of BRAF inhibitors have transformed melanoma therapy however their use in brain tumors remains unproven. 24725538 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 GeneticVariation group BEFREE Autophagy inhibition improves chemosensitivity in BRAF(V600E) brain tumors. 24823863 2015
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 GeneticVariation group BEFREE PKM2-regulated MLC2 phosphorylation, which is greatly enhanced by EGF stimulation or EGFRvIII, K-Ras G12V and B-Raf V600E mutant expression, plays a pivotal role in cytokinesis, cell proliferation and brain tumour development. 25412762 2015
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 GeneticVariation group BEFREE Using BRAF(V600E) as a marker of autophagy dependence in pediatric brain tumors. 25484091 2015
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 Biomarker group BEFREE KIAA1549:BRAF fusion gene in pediatric brain tumors of various histogenesis. 25382612 2015
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 GeneticVariation group BEFREE The patient's resected brain tumor is BRAF V600E mutated, NRAS wild type (WT), and TERT C250T mutated. 26597176 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 GeneticVariation group CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016