Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 Biomarker group BEFREE The use of BRAF inhibitors have transformed melanoma therapy however their use in brain tumors remains unproven. 24725538 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 GeneticVariation group BEFREE BRAF mutations constitute a major genetic alteration in this histologic group of pediatric brain tumors and may serve as a molecular target for biologically based inhibitors. 20156809 2010
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 Biomarker group BEFREE Level 1: The use of afatinib is not recommended in patients with brain metastasis due to breast cancer.There is insufficient evidence to make recommendations regarding: the use of epidermal growth factor receptor inhibitors erlotinib and gefitinib in patients with brain metastasis due to nonsmall cell lung cancerthe use of BRAF inhibitors dabrafenib and vemurafenib in the treatment of patients with brain metastases due to metastatic melanomathe use of HER2 agents trastuzumab and lapatinib to treat patients with brain metastases due to metastatic breast cancerthe use of vascular endothelial growth factor agents bevacizumab, sunitinib, and sorafenib in the treatment of patients with solid tumor brain metastases.The full guideline can be found at: https://www.cns.org/guidelines/guidelines-treatment-adults-metastatic-brain-tumors/chapter_9. 30629215 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 GeneticVariation group BEFREE The BRAF V600E mutation occurs frequently in certain brain tumors such as pleomorphic xanthoastrocytoma, ganglioglioma, and pilocytic astrocytoma, and less frequently in epithelioid and giant cell glioblastoma. 25885250 2015
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 Biomarker group BEFREE Our method successfully detected KIAA1549-v-raf murine sarcoma viral oncogene homolog B1 (BRAF) fusion in 14 out of 19 patients suffering from five types of paediatric brain tumours providing information on fusion breakpoints within 2 h. 29976640 2018
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 GeneticVariation group BEFREE The BRAF V600E mutation and KIAA1549-BRAF fusion are alterations found in several brain tumors and show a distinct prognostic impact in some entities. 31181803 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 GeneticVariation group BEFREE Future clinical trials should address whether BRAF V600E mutant brain tumour patients will benefit from BRAF V600E-directed targeted therapies. 24353007 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 GeneticVariation group BEFREE PKM2-regulated MLC2 phosphorylation, which is greatly enhanced by EGF stimulation or EGFRvIII, K-Ras G12V and B-Raf V600E mutant expression, plays a pivotal role in cytokinesis, cell proliferation and brain tumour development. 25412762 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 Biomarker group BEFREE KIAA1549:BRAF fusion gene in pediatric brain tumors of various histogenesis. 25382612 2015
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 Biomarker group BEFREE Accordingly, this study provides direct evidence of a BRAF somatic mutation contributing to the intrinsic epileptogenicity in pediatric brain tumors and suggests that BRAF and REST could be treatment targets for intractable epilepsy. 30224756 2018
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 GeneticVariation group BEFREE An activating mutation of BRAF (BRAF-V600E) has been reported in a subset of malignant brain tumors. 24721513 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 GeneticVariation group BEFREE The patient's resected brain tumor is BRAF V600E mutated, NRAS wild type (WT), and TERT C250T mutated. 26597176 2015
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 GeneticVariation group BEFREE Using BRAF(V600E) as a marker of autophagy dependence in pediatric brain tumors. 25484091 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 Biomarker group BEFREE Our results also suggest a potential therapeutic target such as BRAF oncogene for inhibition of brain cancer invasion. 28620782 2017
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 GeneticVariation group BEFREE Recently, aberrant methylation of MLH1, MGMT and MSI were shown to be associated with mutations in genes such as BRAF, RAS and IDH1 in colon and brain tumours. 23414134 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 GeneticVariation group BEFREE We found that BRAF mutations cause brain tumor cells to depend on autophagy and display selective chemosensitization with autophagy inhibition. 24823863 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 GeneticVariation group BEFREE Glioneuronal tumors (GNTs) are the most common histological type of brain tumors in patients who received epilepsy surgery, and part of them presented with BRAF V600E mutation. 27984807 2017
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 Biomarker group BEFREE Molecular markers such as MGMT, EGFR, IDH, 1p19q, ATRX, TERT, FGFR-TACC, and BRAF are now being used to classify brain tumors as well as influence management decisions. 28303493 2017
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 GeneticVariation group BEFREE Sorafenib, the first agent developed to target BRAF mutant melanoma, is a multi-kinase inhibitor that was approved by the FDA for therapy of kidney and subsequently liver cancer, and is currently in clinical trials for thyroid, lung and brain cancer. 23792568 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 GeneticVariation group BEFREE Therefore the BRAF V600E mutation is a highly interesting oncological target in brain tumors. 27350555 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 GeneticVariation group BEFREE This experience confirms the potential role of targeted treatments in high-grade BRAF-mutated brain tumors. 29200156 2018
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 GeneticVariation group BEFREE Epithelioid glioblastoma is a recognized glioblastoma variant, recently added to the World Health Organization brain tumor classification, with similar prognosis as the classic variant and B-Raf V600E mutations in 50% of the cases. 31258848 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 GeneticVariation group BEFREE Future clinical trials should address whether BRAF (V600E) mutant brain tumor patients will benefit from BRAF (V600E)-directed targeted therapies. 21274720 2011
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 GeneticVariation group BEFREE Emerging evidence support the effectiveness of targeted therapies for brain tumors with BRAF V600E mutation. 31345255 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.500 GeneticVariation group BEFREE Efficacy of BRAF V600E targeted therapies in brain tumors harboring the mutation has been shown in several case reports and is currently being studied in larger clinical trials. 29380516 2018