| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | AlteredExpression | group | BEFREE | Using a previously described culturing condition that selectively promotes the growth of brain tumor initiating cells, which express the stem cell markers nestin and SOX-2, we characterize the expression of α-amino-3-hydroxy-5-methyl-4-isozolepropionic acid (AMPA)-type glutamate receptor subunits in brain tumor initiating cells derived from glioblastomas. | 23110111 | 2012 | ||||
|
0.080 | AlteredExpression | group | BEFREE | Nestin is an intermediate filament protein expressed in undifferentiated cells during CNS development and in CNS tumors and is used as a marker of immature elements of tumors, including brain tumor stem cells. | 18092184 | 2008 | ||||
|
0.080 | Biomarker | group | BEFREE | The presence of a CD133+/nestin+ population in brain tumors suggests that a normal neural stem cell may be the cell of origin for gliomas. | 17332509 | 2007 | ||||
|
0.080 | AlteredExpression | group | BEFREE | To confirm the immunohistochemical data, nestin expression was analyzed by real-time PCR in 12 brain tumor biopsies. | 17537489 | 2007 | ||||
|
0.080 | AlteredExpression | group | BEFREE | Our work focused on a detailed study of the nestin cytoskeleton in cell lines derived from glioblastoma multiforme, because re-expression of nestin together with down-regulation of GFAP has been previously reported in this type of brain tumor. | 16457706 | 2006 | ||||
|
0.080 | AlteredExpression | group | BEFREE | We have studied how the Notch signaling pathway affects nestin expression in brain tumors. | 17217625 | 2006 | ||||
|
0.080 | Biomarker | group | BEFREE | An oncolytic HSV-1 mutant expressing ICP34.5 under control of a nestin promoter increases survival of animals even when symptomatic from a brain tumor. | 15805284 | 2005 | ||||
|
0.080 | AlteredExpression | group | BEFREE | We retested nestin expression in brain tumors having a range of malignancy grades using immunostaining. | 11896213 | 2002 |