| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | Biomarker | group | BEFREE | The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models. | 29938225 | 2018 | ||||
|
0.090 | Biomarker | group | BEFREE | We attempt to demonstrate the significance of ATM in exploration of breast and brain tumors and its potential as a therapeutic target. | 30197789 | 2018 | ||||
|
0.090 | GeneticVariation | group | BEFREE | Epidemiological studies also revealed the association of variants of GLTSCR1 and ATM genes with different brain tumors. | 30128886 | 2018 | ||||
|
0.090 | AlteredExpression | group | BEFREE | Moreover, bioinformatic analysis with the OncoFinder software against the complete "Cancer Genome Atlas" brain tumor gene expression dataset suggests the involvement of different proteins in the WNT and ATM pathways, and in Aurora B, Sem3A, and E-cadherin signaling. | 28498803 | 2017 | ||||
|
0.090 | Biomarker | group | BEFREE | We hypothesized that the radiosensitivity of this brain tumor is enhanced by silencing of the ATM gene. | 27108486 | 2016 | ||||
|
0.090 | PosttranslationalModification | group | BEFREE | More than 73% of the brain tumors were methylated in ATM gene promoter. | 25159481 | 2015 | ||||
|
0.090 | GeneticVariation | group | BEFREE | The involvement of ATM gene and specifically, the important role of D1853N polymorphism, as a three-hit hypothesis has been previously reported in an Iranian proband affected with brain tumor and this polymorphism could be screened in her relatives as well. | 20396981 | 2011 | ||||
|
0.090 | GeneticVariation | group | BEFREE | P53 and ATM are central checkpoint genes involved in the repair of DNA damage after ionising irradiation, which has been associated with risk of brain tumours. | 17151932 | 2007 | ||||
|
0.090 | Biomarker | group | BEFREE | These data may have implications for ATM disruption strategies as a radiosensitizing treatment for brain tumors. | 10537312 | 1999 |