Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE We show that GPNMB enhances breast cancer cell adhesion to fibronectin, increases α5β1 expression and associates with this receptor through its RGD motif. 25772243 2015
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE We reported previously that fibronectin increased VEGF-dependent migration in breast cancer cells. 11571649 2001
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE We recently showed that fibronectin (FN) leads to Tam resistance and selection of breast cancer stem cells. 31812165 2019
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 AlteredExpression disease BEFREE We performed a proteomic analysis of myosin heavy chain (MHC) phosphorylation sites in MDA-MB 231 breast cancer cells to identify MHC phosphorylation sites that are activated during integrin engagement and lamellar extension on fibronectin. 21316371 2011
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE We found an overall increase in these processes with increasing concentration on both laminin and fibronectin gradients for a series of ovarian and breast cancer lines. 29177019 2017
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE We demonstrate that conditioned medium from ASCs induces breast cancer cells (4T1) to express mesenchymal markers such as fibronectin, alpha smooth muscle actin and vimentin. 22038895 2012
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 GeneticVariation disease BEFREE We conclude that the FZD6-fibronectin actin axis identified in our study could be exploited for drug development in highly metastatic forms of breast cancer, such as TNBC.© 2016 The Authors. 27859262 2017
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Using this breast cancer (BC) model, we find that in addition to EGF, adhesion to fibronectin (FN) activates signal transducer and activator of transcription 3 (STAT3) through EGFR-dependent and -independent mechanisms. 23653350 2013
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 AlteredExpression disease BEFREE Using publicly available clinical data, we observed that high FN expression was associated with poor prognosis in patients with breast cancer. 29628980 2018
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE This Cav-1(-/-) MSF gene signature is predictive of poor clinical outcome in breast cancer patients treated with tamoxifen. 19234134 2009
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 AlteredExpression disease BEFREE The lysyl oxidase pro-peptide attenuates fibronectin-mediated activation of focal adhesion kinase and p130Cas in breast cancer cells. 19029090 2009
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE The liver-aggressive breast cancer cells display a claudin-2-mediated increase in their ability to adhere to extracellular matrix (ECM) components, such as fibronectin and type IV collagen. 21076473 2011
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE The extracellular matrix protein fibronectin (FN) facilitates tumorigenesis and the development of breast cancer. 31000696 2019
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 AlteredExpression disease BEFREE Tenascin (TN)-C and fibronectin (FN), which are glycoproteins of the extracellular matrix (ECM), are up-regulated in cancer tissues, including breast cancer. 9306963 1997
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Targeted Therapy for Breast Cancer Stem Cells by Liposomal Delivery of siRNA against Fibronectin EDB. 26097122 2015
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 AlteredExpression disease BEFREE Taken together, these results demonstrate that FN expression is upregulated through the PI-3K/Akt pathway in tamoxifen-resistant breast cancer cells.[BMB Reports 2017; 50(12): 615-620]. 28855026 2017
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 AlteredExpression disease BEFREE Subsequently, a large panel of breast cancer cell lines was used to validate that hypoxia induces the expression of integrins that bind to collagen (ITGA1, ITGA11, ITGB1) and fibronectin (ITGA5, ITGB1). 28213554 2017
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE RNA interference of endogenous PTHrP caused a significant reduction in cell adhesion of a breast cancer cell line to collagen type I, fibronectin and laminin (P<0.05) and of a colon cancer cell to collagen type I and fibronectin (P<0.05). 17406357 2007
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Rapid expression and activation of MMP-2 and MMP-9 upon exposure of human breast cancer cells (MCF-7) to fibronectin in serum free medium. 18243246 2008
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Previous studies have shown that FN can be degraded into fragments by MMP-9 in vitro; MMP-9 expression is upregulated in breast cancer, therefore, the role of degraded FN in breast cancer progression needs to be investigated. 26134759 2015
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Previous studies from our laboratory and others have demonstrated that treatment of breast cancer cells with exogenous maspin led to a significant decrease in cell motility, and an increase in cell adhesion to human fibronectin. 14508113 2004
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Our findings offer preclinical validation of fibronectin and alpha5beta1-integrin as targets for breast cancer therapy. 20516121 2010
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 GeneticVariation disease BEFREE Migratory inhibition upon STAT5b knockdown could be rescued by reintroduction of wild-type STAT5b, as well as Y699F- and dominant-negative STAT5b mutants, but not an SH2 domain defective R618K-STAT5b mutant. beta1- integrin-mediated migration of breast cancer cells to fibronectin was inhibited with STAT5b knockdown, and loss of STAT5b correlated with loss of directional migration and formation of multiple, highly contractile protrusions upon attachment to fibronectin. 19630967 2009
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 AlteredExpression disease BEFREE MENA(INV) and FN levels were correlated in two breast cancer cohorts, and high levels of MENA(INV) were significantly associated with increased tumor recurrence as well as decreased patient survival. 26811325 2016
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease CTD_human MCF-7 cells expressing nuclear associated lysyl oxidase-like 2 (LOXL2) exhibit an epithelial-to-mesenchymal transition (EMT) phenotype and are highly invasive in vitro. 24014025 2013