Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 AlteredExpression disease BEFREE Tenascin (TN)-C and fibronectin (FN), which are glycoproteins of the extracellular matrix (ECM), are up-regulated in cancer tissues, including breast cancer. 9306963 1997
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE We reported previously that fibronectin increased VEGF-dependent migration in breast cancer cells. 11571649 2001
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Previous studies from our laboratory and others have demonstrated that treatment of breast cancer cells with exogenous maspin led to a significant decrease in cell motility, and an increase in cell adhesion to human fibronectin. 14508113 2004
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 AlteredExpression disease BEFREE We conclude that the expression of TG2 in breast cancer cells contributes to the development of the drug-resistance phenotype by promoting interaction between integrins and Fn. 16449978 2006
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 AlteredExpression disease BEFREE These results suggested that induction of fibronectin 1 gene expression in MDA-MB-231 cells by rtEa4-peptide may be mediated via PI3K, PKC, Mek1/2, JNK1/2, and p38 MAPK signal transduction molecules. 16817231 2007
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Using in vitro assays, AII (10(-6) M)-treated MCF-7 and T47D breast cancer cells both show reduced adhesion to extracellular matrix proteins collagen-, fibronectin- and laminin-coated wells (P<0.001) and reduced invasion through collagen-, fibronectin- and laminin-coated membranes (P<0.05). 16954438 2007
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 GeneticVariation disease UNIPROT The consensus coding sequences of human breast and colorectal cancers. 16959974 2006
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE In this study, we evaluated the ability of ATN-161 (Ac-PHSCN-NH2), a 5-mer capped peptide derived from the synergy region of fibronectin that binds to alpha5beta1 and alphavbeta3 in vitro, to block breast cancer growth and metastasis. 16985061 2006
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Conversely, ectopic expression of TG2 augmented invasion of breast cancer cells and attachment to Fn-coated surfaces. 17043648 2007
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE RNA interference of endogenous PTHrP caused a significant reduction in cell adhesion of a breast cancer cell line to collagen type I, fibronectin and laminin (P<0.05) and of a colon cancer cell to collagen type I and fibronectin (P<0.05). 17406357 2007
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Rapid expression and activation of MMP-2 and MMP-9 upon exposure of human breast cancer cells (MCF-7) to fibronectin in serum free medium. 18243246 2008
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Most importantly, siRNA-downregulation of hB7H3 reduced cell adhesion to fibronectin of melanoma and breast cancer cells by up to 50 %, and migration and matrigel-invasion by more than 70 %, but surprisingly had no apparent impact on cell proliferation. 18690846 2008
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 AlteredExpression disease BEFREE The lysyl oxidase pro-peptide attenuates fibronectin-mediated activation of focal adhesion kinase and p130Cas in breast cancer cells. 19029090 2009
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE This Cav-1(-/-) MSF gene signature is predictive of poor clinical outcome in breast cancer patients treated with tamoxifen. 19234134 2009
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Our results suggest that GPR30 coordinates estrogen-mediated FN matrix assembly and growth factor release in human breast cancer cells via a Shc-dependent signaling mechanism that activates integrin alpha5beta1. 19342448 2009
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 GeneticVariation disease BEFREE Migratory inhibition upon STAT5b knockdown could be rescued by reintroduction of wild-type STAT5b, as well as Y699F- and dominant-negative STAT5b mutants, but not an SH2 domain defective R618K-STAT5b mutant. beta1- integrin-mediated migration of breast cancer cells to fibronectin was inhibited with STAT5b knockdown, and loss of STAT5b correlated with loss of directional migration and formation of multiple, highly contractile protrusions upon attachment to fibronectin. 19630967 2010
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Gene expression profiling identifies Fibronectin 1 and CXCL9 as candidate biomarkers for breast cancer screening. 20068563 2010
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE In summary, our findings offer evidence that mda-9/syntenin acts as a molecular adaptor linking PKCalpha and FAK activation in a pathway of FN adhesion by human breast cancer and melanoma cells. 20145126 2010
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Our findings offer preclinical validation of fibronectin and alpha5beta1-integrin as targets for breast cancer therapy. 20516121 2010
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE The liver-aggressive breast cancer cells display a claudin-2-mediated increase in their ability to adhere to extracellular matrix (ECM) components, such as fibronectin and type IV collagen. 21076473 2011
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Here, we study the effect of EGFR alone and in collaboration with fibronectin on the status of MMP-9 in human breast cancer cell MDA-MB-231 and its molecular mechanism; study the role of EGCG on the induced MMP-9; and elucidate the signaling molecules involved in the process. 21170718 2011
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 AlteredExpression disease BEFREE We performed a proteomic analysis of myosin heavy chain (MHC) phosphorylation sites in MDA-MB 231 breast cancer cells to identify MHC phosphorylation sites that are activated during integrin engagement and lamellar extension on fibronectin. 21316371 2011
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Herein, we found that SRC-1 deficiency in mouse and human breast cancer cells substantially reduced cell adhesion and migration capabilities on fibronectin and significantly extended the time of focal adhesion disassembly and reassembly. 21343398 2011
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 AlteredExpression disease BEFREE Exposure of estrogen-independent MDA-MB-231 and estrogen-responsive MCF-7 human breast cancer cell lines and a pancreatic cancer cell line (PL-45) to BITC resulted in upregulation of epithelial markers (e.g., E-cadherin and/or occludin) with a concomitant decrease in protein levels of mesenchymal markers, including vimentin, fibronectin, snail, and/or c-Met. 21464039 2011
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.600 Biomarker disease BEFREE Because knockdown of fibronectin abrogated the disruptive proliferation caused by introduction of GALNT6 into epithelial cells, our findings suggest that GALNT6-fibronectin pathway should be a critical component for breast cancer development and progression. 21472136 2011