Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 AlteredExpression disease BEFREE Exogenous exposure to TGF-β1 was sufficient to drive the metastasis of an otherwise in situ model of BC and was similarly associated with a depletion and return of E-cad expression during metastatic progression. 24618085 2014
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE A significant association was found between TP53Arg72Pro (rs1042522) and CDH1 -160 C/A (rs16260) polymorphisms and breast cancer risk. 26666818 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE Cell adhesion was affected by mutations of CDH1 in 1 breast cancer. 25591616 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE Variants in CDH1 have been linked to familial hereditary diffuse gastric cancer and invasive lobular breast cancer; however, no cases of gastric or breast cancer have been reported in our BCDS cases. 29348693 2018
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 PosttranslationalModification disease BEFREE We found that increased methylation in the E-cadherin promoter region and decreased methylation in satellite 2 DNA were often present in the same breast cancers. 9714050 1998
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE This study aimed to investigate the frequency of germline CDH1 mutations in patients with LBC with early onset disease or family histories of breast cancer without DGC. 17660459 2007
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE To determine if CDH1 is a susceptibility gene for lobular breast cancer in women without a family history of diffuse gastric cancer, germline DNA was analysed for the presence of CDH1 mutations in 318 women with lobular breast cancer who were diagnosed before the age of 45 years or had a family history of breast cancer and were not known, or known not, to be carriers of germline mutations in BRCA1 or BRCA2. 20921021 2011
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE Our meta-analysis demonstrated that the -160C/A polymorphism in the CDH1 gene might contribute to breast cancer susceptibility. 27349965 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 AlteredExpression disease BEFREE The aim of our study was to assess the methylation pattern of CDH1 and to correlate it with the expression of E-cadherin, clinicopathological parameters and hormone receptor status in breast cancer patients of Kashmir. 25124632 2014
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 PosttranslationalModification disease BEFREE Here we present analyses of CDH1 expression, genetic mutation, and promoter methylation in CDH1 in 10 commonly used breast cancer cell lines. 9581841 1998
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE Although none of these associations retained statistical significance after correcting for the total number of polymorphisms evaluated, this study suggests that genetic variation in CDH1 may be associated with breast cancer risk, and that this relationship may vary by menopausal status. 19834798 2010
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE Breast cancer surveillance with annual breast MRI starting at age 30 for women with a CDH1 mutation is recommended. 25979631 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 Biomarker disease BEFREE E-, N-, P-, VE-, Proto-, desmosomal and FAT cadherins have been found to regulate breast cancer in positive as well as negative fashion, whereby both Ecadherin (CDH1) and N-cadherin (CDH2) contribute significantly towards transitioning from epithelial state to mesenchymal state (EMT) and enacting the abnormal cells to invade and metastasize nearby and distant tissues. 26825466 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 Therapeutic disease CTD_human Promoter methylation as a common mechanism for inactivating E-cadherin in human salivary gland adenoid cystic carcinoma. 17520682 2007
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE Here, we identified E-cadherin gene mutations exclusively in human breast cancer cell lines that grow with a rounded cell morphology. 19763817 2010
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE WES detected numerous mutations, some of which affecting BC associated genes as CDH1, HEPACAM, and LOXHD1. 29287594 2017
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 AlteredExpression disease BEFREE The hypermethylation of CDH-1 and the expression of bcl-2, cyclin D1, and beta-catenin proteins differ among breast cancer subtypes. 18701415 2008
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 Therapeutic disease CTD_human 3,5,4'-Trimethoxystilbene, a natural methoxylated analog of resveratrol, inhibits breast cancer cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchymal transition. 23921149 2013
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 PosttranslationalModification disease BEFREE Besides, methylation status in promoter of breast cancer related genes CDH1, SFN, TNFRSF10C were also changed, which implied that BPS might play a role in the development of breast cancer. 30616060 2019
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 Biomarker disease BEFREE We showed previously that breast cancer chemoprevention with benzyl isothiocyanate (BITC) in MMTV-neu mice was associated with induction of E-cadherin protein in vivo. 23276794 2013
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE This study indicated that the genetic polymorphisms of CDH1 and CTNNB1 were associated with breast cancer susceptibility and patients' prognosis. 26285011 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE Multiple DGC cases in a family, DGC at a young age in an individual or the combination of DGC andlobular breast cancer (LBC) in an individual or a family define the hereditary DGC syndrome (HDGC), and testing for germline CDH1 mutations is warranted in HDGC. 23709761 2013
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 Biomarker disease BEFREE An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation. 24292671 2014
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 Biomarker disease BEFREE Methylation-specific PCR analysis of seven genes frequently methylated in breast cancer (HIN-1, Twist, Cyclin D2, RARbeta, GSTP1, RASSF1A and CDH1) was performed on DNA from 67 Korean and 50 Caucasian invasive ductal breast cancers which were categorized into four subgroups by ER status and age. 17611401 2007
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE In a case-control study, we also tested whether a variant adenine allele in the promoter polymorphism -161C-->A with a putative influence on the transcriptional activity of CDH1 in vitro confers any detectable risk of breast cancer. 11857408 2002