Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease UNIPROT
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 CausalMutation disease CLINVAR
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 Biomarker disease GENOMICS_ENGLAND
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 Biomarker disease BEFREE We have examined the expression of the epithelial-specific cell adhesion molecule uvomorulin (E-cadherin, cell-CAM 120/80, L-CAM) in human breast cancer cell lines. 1793731 1991
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE We have analysed a series of 49 human breast cancers for mutations in the entire coding region plus flanking intron sequences of the E-cadherin gene. 8934538 1996
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 PosttranslationalModification disease BEFREE We found that increased methylation in the E-cadherin promoter region and decreased methylation in satellite 2 DNA were often present in the same breast cancers. 9714050 1998
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 PosttranslationalModification disease BEFREE Here we present analyses of CDH1 expression, genetic mutation, and promoter methylation in CDH1 in 10 commonly used breast cancer cell lines. 9581841 1998
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE Frequent inactivating mutations have been identified for the E-cadherin gene (CDH1) in diffuse gastric cancers and lobular breast cancers. 9744472 1998
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE These results demonstrate that germline mutation of the E-cadherin gene is a common cause of hereditary diffuse gastric cancer and suggest a role for these mutations in the incidence of breast cancer. 10477433 1999
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE We have studied a set of 40 human lobular breast cancers for loss of heterozygosity (LOH) at various chromosome locations and for mutations in the coding region plus flanking intron sequences of the E-cadherin gene. 10584868 1999
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE Here, we analyzed by PCR and direct cycle sequencing 26 human breast cancer cell lines for alterations in the E-cadherin gene. 11196175 2001
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE The purpose of this study was to estimate the cumulative risk of gastric and breast cancer in CDH1 mutation carriers. 11729114 2001
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE In a case-control study, we also tested whether a variant adenine allele in the promoter polymorphism -161C-->A with a putative influence on the transcriptional activity of CDH1 in vitro confers any detectable risk of breast cancer. 11857408 2002
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 Biomarker disease BEFREE Taken together, the data indicate the E-box elements in the proximal E-cadherin promoter are critical in transcriptional repression of the E-cadherin gene, and SLUG is a likely in vivo repressor of E-cadherin in breast cancer. 11912130 2002
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 PosttranslationalModification disease BEFREE Methylation-specific PCR (MSP) assay was done to evaluate the promoter methylation status of E-cadherin gene in primary tumor samples from 23 cases of Chinese women with invasive ductal breast cancers. 12127160 2002
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE The aim of this study was to investigate if germline mutations in CDH1 could explain the risk for cancer in HPC families with an excess of gastric and breast cancer. 11948460 2002
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE One of the main differences between lobular breast cancers and ductal carcinomas is the presence of inactivating E-cadherin gene mutations in lobular breast cancers. 12973049 2003
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE This is the first report of CDH1 germline mutations gastric cancer/breast cancer syndrome in Chinese patients. 15135482 2004
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 PosttranslationalModification disease BEFREE Aberrant CDH1 methylation was detected in 25% (9/36) of primary tumors and 20% (7/36) of plasma samples. p16 and/or CDH1 hypermethylation was found in 31% (11/36) of primary breast carcinomas and 82% (9/11) of breast cancer patients with tumoral methylation showing identical epigenetic changes in plasma. 14534701 2004
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 AlteredExpression disease BEFREE These results suggested HNF3 may play important roles in the upregulation of the E-cadherin promoter, with the consequent re-expression of E-cadherin, thus reducing the metastatic potential of breast cancer cells. 16116478 2005
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 AlteredExpression disease BEFREE The aim of our study was to assess, by Methylation-Specific Polymerase Chain Reaction (MSP), the methylation pattern of the CDH1 gene and its possible correlation with the expression of E-cadherin and other standard immunohistochemical parameters (Her-2, ER, PgR, p53, and K-67) in a series of 79 primary breast cancers (71 infiltrating ductal, 5 infiltrating lobular, 1 metaplastic, 1 apocrine, and 1 papillary carcinoma). 16512896 2006
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE This study aimed to investigate the frequency of germline CDH1 mutations in patients with LBC with early onset disease or family histories of breast cancer without DGC. 17660459 2007
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 Therapeutic disease CTD_human Promoter methylation as a common mechanism for inactivating E-cadherin in human salivary gland adenoid cystic carcinoma. 17520682 2007
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 Biomarker disease BEFREE Methylation-specific PCR analysis of seven genes frequently methylated in breast cancer (HIN-1, Twist, Cyclin D2, RARbeta, GSTP1, RASSF1A and CDH1) was performed on DNA from 67 Korean and 50 Caucasian invasive ductal breast cancers which were categorized into four subgroups by ER status and age. 17611401 2007
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 Biomarker disease CTD_human Promoter methylation as a common mechanism for inactivating E-cadherin in human salivary gland adenoid cystic carcinoma. 17520682 2007