Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease UNIPROT
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 CausalMutation disease CLINVAR
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 Biomarker disease GENOMICS_ENGLAND
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 Therapeutic disease CTD_human 3,5,4'-Trimethoxystilbene, a natural methoxylated analog of resveratrol, inhibits breast cancer cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchymal transition. 23921149 2013
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 Biomarker disease CTD_human 3,5,4'-Trimethoxystilbene, a natural methoxylated analog of resveratrol, inhibits breast cancer cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchymal transition. 23921149 2013
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE Breast cancer surveillance with annual breast MRI starting at age 30 for women with a CDH1 mutation is recommended. 25979631 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE CDH1 was positioned among the 20 genes with highest mutation frequency and was confirmed as driver gene in breast cancer. 26674224 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE E-cadherin genetic variants predict survival outcome in breast cancer patients. 27852262 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 AlteredExpression disease BEFREE A set of transcriptional repressors of E-cadherin (CDH1) gene expression, including Snail1, Snail2 and Zeb2 mediate E-cadherin downregulation in breast cancer. 28135249 2017
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE A significant association was found between TP53Arg72Pro (rs1042522) and CDH1 -160 C/A (rs16260) polymorphisms and breast cancer risk. 26666818 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE A small group of cases are secondary to mutations in other breast cancer susceptibility genes, such as p53, PTEN or CDH1. 18544963 2008
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 PosttranslationalModification disease BEFREE Aberrant CDH1 methylation was detected in 25% (9/36) of primary tumors and 20% (7/36) of plasma samples. p16 and/or CDH1 hypermethylation was found in 31% (11/36) of primary breast carcinomas and 82% (9/11) of breast cancer patients with tumoral methylation showing identical epigenetic changes in plasma. 14534701 2004
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE Accurate estimates of gastric and breast cancer risks in CDH1 mutation carriers and the relative contribution of other cancer predisposition genes in familial gastric cancers. 26182300 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 AlteredExpression disease BEFREE Additionally, E-cadherin was highly expressed in 29.69% (87/293) of patients with lymph node metastasis of breast cancer, with low expression in 70.31% (206/293); these differences were significantly different (χ<sup>2</sup>=16.53; P<0.001). 30008850 2018
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE Although none of these associations retained statistical significance after correcting for the total number of polymorphisms evaluated, this study suggests that genetic variation in CDH1 may be associated with breast cancer risk, and that this relationship may vary by menopausal status. 19834798 2010
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 Biomarker disease BEFREE An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation. 24292671 2014
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 PosttranslationalModification disease BEFREE Besides, methylation status in promoter of breast cancer related genes CDH1, SFN, TNFRSF10C were also changed, which implied that BPS might play a role in the development of breast cancer. 30616060 2019
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 GeneticVariation disease BEFREE Cell adhesion was affected by mutations of CDH1 in 1 breast cancer. 25591616 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 Biomarker disease BEFREE Clinicopathological significance and potential drug target of CDH1 in breast cancer: a meta-analysis and literature review. 26425077 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 AlteredExpression disease BEFREE Conversely, silencing of Notch3 in the breast cancer cell line, MCF-7, caused a decrease in expression levels of Cdh1 and p27(Kip) at both the protein and mRNA levels, while the expression of Skp2 only increased at the protein level. 26694515 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 Biomarker disease BEFREE Depleting Cdh1 accelerates breast cancer cell proliferation and cooperates with PTEN loss to promote breast tumor progression in mice. 31420536 2019
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 AlteredExpression disease BEFREE Depleting or increasing miR-221 level in breast cancer cells induced or decreased E-cadherin protein level, leading to suppressing or promoting tumor cell progression, respectively. 27174021 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 Biomarker disease BEFREE E-, N-, P-, VE-, Proto-, desmosomal and FAT cadherins have been found to regulate breast cancer in positive as well as negative fashion, whereby both Ecadherin (CDH1) and N-cadherin (CDH2) contribute significantly towards transitioning from epithelial state to mesenchymal state (EMT) and enacting the abnormal cells to invade and metastasize nearby and distant tissues. 26825466 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 Biomarker disease CTD_human E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells. 19839049 2010
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.800 Therapeutic disease CTD_human E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells. 19839049 2010