Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
1.000 Biomarker disease BEFREE Our results could provide important markers to be validated in BC patient samples, and subsequently used for predicting the outcome in ERα+ and ERα- tumors after TAM or hormonal therapy. 29033607 2017
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
1.000 Biomarker disease BEFREE Physicians' recommendations about tamoxifen use in mutation carriers with a history of breast cancer seem to be heavily dependent on ER status. 14645421 2003
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
1.000 AlteredExpression disease BEFREE ERα expression may have major roles in modulating breast cancer cell radiosensitivity. 28570501 2017
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
1.000 GeneticVariation disease BEFREE A plethora of studies have reported the detection of estrogen receptor mRNA splice variants, and it has been suggested that the accumulation of these variant mRNAs are responsible for the development of tamoxifen-resistant breast cancer. 9393947 1997
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
1.000 Biomarker disease BEFREE Previously, using a gene expression profiling and immunohistochemistry (IHC) screen, we identified TRPS-1 as a highly prevalent gene in breast cancer (BC), expressed in >90% of estrogen receptor alpha (ERα)(+) and ERα(-) BC subtypes. 21761348 2010
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
1.000 Biomarker disease BEFREE Down-regulation of cyclin-dependent kinase-4 and MAPK through estrogen receptor mediated cell cycle arrest in human breast cancer induced by gold nanoparticle tagged toxin protein NKCT1. 28322778 2017
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
1.000 Biomarker disease BEFREE Compared with the female patients with breast cancer aged <40, the male patients with breast cancer aged <40 had worse OS and CSS benefit only in the subgroup with progesterone receptor and estrogen receptor positive (P < .05). 30290658 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
1.000 AlteredExpression disease BEFREE In this study, we analyzed ER expression concordance between breast cancer primary tumor and metastatic lesions. 30587150 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
1.000 GeneticVariation disease BEFREE Reproductive factors, particularly parity, have differential effects on breast cancer risk according to estrogen receptor (ER) status, especially among African American (AA) women. 28756535 2017
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
1.000 AlteredExpression disease BEFREE These findings reveal a novel role for FOXM1 in ERα transcriptional activity in breast cancer and uncover a FOXM1-regulated gene signature associated with ER-positive breast cancer patient prognosis. 23347430 2013
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
1.000 Biomarker disease BEFREE Accumulating evidence suggests that both levels and activity of the estrogen receptor (ER) and the progesterone receptor (PR) are dramatically influenced by growth-factor receptor (GFR) signaling pathways, and that this crosstalk is a major determinant of both breast cancer progression and response to therapy. 20569503 2010
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
1.000 AlteredExpression disease BEFREE We examined separately the prognostic and predictive values of tau mRNA expression in estrogen receptor (ER)-positive primary breast cancers in three patient cohorts. 17404087 2007
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
1.000 Biomarker disease BEFREE It is, however, unclear as to how estrogen-ER interaction potentiates breast cancer progression. 23000059 2012
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
1.000 AlteredExpression disease BEFREE Reassessment of estrogen receptor expression in human breast cancer cell lines. 21378333 2011
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
1.000 Biomarker disease BEFREE Moesin may play a role in the invasiveness and pattern of metastasis characteristic of ER-negative breast cancers. 9706140 1998
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
1.000 Biomarker disease BEFREE In sum, identification of PIM-1 as an ERα target gene adds a novel potential mechanism by which estrogens can contribute to breast cancer cell proliferation and carcinogenesis. 23142699 2013
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
1.000 Biomarker disease BEFREE APC was hypermethylated in 29%, RASSF1A in 35% and ESR1 in 20% of breast cancer cases. 19367284 2009
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
1.000 Biomarker disease BEFREE ESR1 mutations: a new biomarker in breast cancer. 31188645 2019
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
1.000 GeneticVariation disease BEFREE According to the selected cutoff, ESR1 mutations occurred in 7 (2.5%) of 270 primary breast cancer specimens and in 11 (20%) of 55 ER+ MBC specimens. 26434753 2015
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
1.000 GeneticVariation disease BEFREE Thus, our results provide evidence that ESR-α polymorphisms are associated with susceptibility to breast cancer. 24377599 2014
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
1.000 Biomarker disease BEFREE Estrogens are key factors in the development of the estrogen receptor-positive (ER<sup>+</sup>) breast cancer. 31440781 2019
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
1.000 Biomarker disease BEFREE VULCAN analysis of estrogen receptor activation in breast cancer highlights the key components of the estrogen receptor complex alongside a novel interaction with GRHL2. 31084623 2019
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
1.000 Biomarker disease BEFREE A similar advantageous effect, but statistically underpowered, was found in estrogen receptor (ER)-positive, ER-negative, and HER2neu-positive tumors.<b>Conclusions:</b> The use of oral bisphosphonates, by postmenopausal, probably osteoporotic, women initiated after diagnosis of breast cancer was associated with a significant improvement in overall and breast-specific odds of survival.<i></i>. 27683176 2017
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
1.000 Biomarker disease BEFREE Hence, ER status may be identified as an independent prognostic factor for predicting young women with breast cancer. 27712977 2016
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
1.000 PosttranslationalModification disease BEFREE Thus this study aimed to clarify the correlation of different IHC-based subtypes of breast tumors with ERα methylation in Iranian breast cancer patients. 23098526 2012