Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.800 Biomarker disease BEFREE The CHEK2 gene and its encoded protein Chk2 have a well-known role in cancers, especially those related to breast cancer mediated through the BRCA1 gene. 30633282 2019
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.800 Biomarker disease BEFREE CHK2 is a well-studied moderate penetrance gene that correlates with third high risk susceptibility gene with an increased risk for breast cancer. 31398194 2019
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.800 GeneticVariation disease CLINVAR Association of Breast and Ovarian Cancers With Predisposition Genes Identified by Large-Scale Sequencing. 30128536 2019
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.800 GeneticVariation disease BEFREE Enrichment of pathogenic variants were identified in 4 non-BRCA genes associated with breast cancer risk: ATM (odds ratio [OR], 2.97; 95% CI, 1.67-5.68), CHEK2 (OR, 2.19; 95% CI, 1.40-3.56), PALB2 (OR, 5.53; 95% CI, 2.24-17.65), and MSH6 (OR, 2.59; 95% CI, 1.35-5.44). 30128536 2019
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.800 GeneticVariation disease BEFREE In addition, mutations in CHEK2 lead to resistance of BC cells to chemotherapy and metastasis of cancer cells to other parts of the body. 31220302 2019
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.800 GeneticVariation disease BEFREE In total, 120 germline CHEK2 missense variants, distributed along the protein sequence, and two large in-frame deletions were tested, originating from genetic test results in breast cancer families, or selected from the ClinVar database. 30851065 2019
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.800 Biomarker disease BEFREE As part of the CAGI-5 challenge, we evaluated the performance of 18 submissions and three additional methods in predicting the pathogenicity of single nucleotide variants (SNVs) in checkpoint kinase 2 (CHEK2) for cases of breast cancer in Hispanic females. 31241222 2019
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.800 GeneticVariation disease BEFREE Next-generation-sequencing-based targeted cancer-related gene assay confirmed <i>SMARCB1</i> loss and revealed other mutations in breast cancer 1 gene and checkpoint kinase 2 gene, which may have impacted her clinical course. 30297384 2019
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.800 GeneticVariation disease BEFREE Germline DNA from 1054 BRCA-mutation-negative Hispanic women with hereditary BC (BC diagnosed at age <51 years, bilateral BC, breast and ovarian cancer, or BC diagnosed at ages 51-70 years with ≥2 first-degree or second-degree relatives who had BC diagnosed at age <70 years), 312 local controls, and 887 multiethnic cohort controls was sequenced and analyzed for 12 known and suspected, high-penetrance and moderate-penetrance cancer susceptibility genes (ataxia telangiectasia mutated [ATM], breast cancer 1 interacting protein C-terminal helicase 1 [BRIP1], cadherin 1 [CDH1], checkpoint kinase 2 [CHEK2], nibrin [NBN], neurofibromatosis type 1 [NF1], partner and localizer of BRCA2 [PALB2], phosphatase and tensin homolog [PTEN], RAD51 paralog 3 [RAD51C], RAD51D, serine/threonine kinase 11 [STK11], and TP53). 31206626 2019
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.800 GeneticVariation disease BEFREE Clinically actionable BC susceptibility PVs, particularly in BRCA2 and CHEK2, were relatively prevalent among older women undergoing genetic testing. 31012959 2019
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.800 GeneticVariation disease BEFREE We analyzed germline CHEK2 variants in 1,928 high-risk Czech breast/ovarian cancer (BC/OC) patients and 3,360 population-matched controls (PMCs). 31050813 2019
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.800 GeneticVariation disease BEFREE The most important cause of developing hereditary breast cancer is germline mutations occurring in breast cancer (BCs) susceptibility genes, for example, BRCA1, BRCA2, TP53, CHEK2, PTEN, ATM, and PPM1D. 30552672 2019
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.800 GeneticVariation disease BEFREE This case provides insight into the role of the CHEK2 gene in causing breast cancer susceptibility in families and supports the use of multigene panel testing in cases with hereditary predisposition to breast cancer. 31296309 2019
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.800 GeneticVariation disease CLINVAR Pancreatic cancer as a sentinel for hereditary cancer predisposition. 29945567 2018
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.800 GeneticVariation disease BEFREE Patients with CHEK2 mutations are significantly more likely to have family histories of cancer, and to develop lymph node-positive and/or PR-positive breast cancers. 29356917 2018
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.800 GeneticVariation disease BEFREE Characterization and prevalence of two novel CHEK2 large deletions in Greek breast cancer patients. 29785007 2018
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.800 GeneticVariation disease BEFREE However, the impact of screening and preventative interventions and spectrum of cancer risk beyond breast cancer associated with ATM and/or CHEK2 variants remain less well characterized. 29445900 2018
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.800 GeneticVariation disease CLINVAR Potentially pathogenic germline CHEK2 c.319+2T>A among multiple early-onset cancer families. 28608266 2018
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.800 Biomarker disease BEFREE In vivo Chk2 and antitumor activities of 8d as a single-agent, and in combination with doxorubicin, were evaluated in breast cancer bearing animals induced by N-methylnitrosourea. 29316526 2018
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.800 GeneticVariation disease BEFREE The association between the checkpoint kinase 2*1100delC (CHEK2*1100delC) and breast cancer has been extensively explored. 29909568 2018
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.800 GeneticVariation disease CLINVAR Association Between Inherited Germline Mutations in Cancer Predisposition Genes and Risk of Pancreatic Cancer. 29922827 2018
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.800 Biomarker disease BEFREE ART can inhibit cell proliferation and promote G2/M arrest in MCF7 cells through ATM activation and the ensuing "ATM-Chk2-Cdc25C" pathway, thus implicating ART as a novel candidate for breast cancer chemotherapy. 29797234 2018
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.800 GeneticVariation disease CLINVAR Novel genetic mutations detected by multigene panel are associated with hereditary colorectal cancer predisposition. 30256826 2018
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.800 GeneticVariation disease BEFREE CHEK2 mutations may be a rare event in Rwandan population and may only play a minor if an role in breast cancer 29479983 2018
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
0.800 GeneticVariation disease CLINVAR Contribution of germline mutations in cancer predisposition genes to tumor etiology in young women diagnosed with invasive breast cancer. 28503720 2017