Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.900 Biomarker disease BEFREE The 21-gene recurrence score (RS) assay predicts the likelihood of distant recurrence and chemotherapy benefit in early-stage, estrogen receptor (ER)-positive, HER2-negative breast cancer. 28577081 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.900 Biomarker disease BEFREE Accurate determination of the predictive markers human epidermal growth factor receptor 2 (HER2/ERBB2), estrogen receptor (ER/ESR1), progesterone receptor (PgR/PGR), and marker of proliferation Ki67 (MKI67) is indispensable for therapeutic decision making in early breast cancer. 28490348 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.900 Biomarker disease BEFREE Models that predict the risk of estrogen receptor (ER)-positive breast cancers may improve our ability to target chemoprevention. 28791495 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.900 Biomarker disease BEFREE A Novel Strategy to Co-target Estrogen Receptor and Nuclear Factor κB Pathways with Hybrid Drugs for Breast Cancer Therapy. 28396978 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.900 GeneticVariation disease BEFREE Association between ERα gene Pvu II polymorphism and breast cancer susceptibility: A meta-analysis. 29702977 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.900 Biomarker disease BEFREE We studied 1347 women with ER-positive breast cancer who were treated at Women's College Hospital between 1987 and 2000. 28374324 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.900 Biomarker disease BEFREE The estrogen receptor (ER) drives the growth of most luminal breast cancers and is the primary target of endocrine therapy. 28507152 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.900 GeneticVariation disease BEFREE Genome-Wide Association Studies (GWAS) and subsequent fine-mapping studies (>50) have implicated single nucleotide polymorphisms (SNPs) located at the CCDC170/C6ORF97-ESR1 locus (6q25.1) as being associated with the risk of breast cancer. 28687497 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.900 Biomarker disease BEFREE Androgen Receptor Expression and Bicalutamide Antagonize Androgen Receptor Inhibit β-Catenin Transcription Complex in Estrogen Receptor-Negative Breast Cancer. 29069648 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.900 Biomarker disease BEFREE Association of FGFR1 with ERα Maintains Ligand-Independent ER Transcription and Mediates Resistance to Estrogen Deprivation in ER<sup>+</sup> Breast Cancer. 28751448 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.900 Biomarker disease BEFREE Genomic signatures are needed for the determination of prognosis in patients with early stage, estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancers. 29715116 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.900 Biomarker disease BEFREE Twenty to fifty percent of estrogen receptor-positive (ER+) metastatic breast cancers express mutations within the ER ligand-binding domain. 29306943 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.900 Biomarker disease BEFREE <b>Purpose:</b> Cyclin-dependent kinase (CDK) 4/6 drives cell proliferation in estrogen receptor-positive (ER<sup>+</sup>) breast cancer. 28270497 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.900 Biomarker disease BEFREE Dual Src Kinase/Pretubulin Inhibitor KX-01, Sensitizes ERα-negative Breast Cancers to Tamoxifen through ERα Reexpression. 28751463 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.900 Biomarker disease BEFREE Endocrine therapy is used as maintenance in estrogen receptor (ER) positive breast cancers and has been proposed in low-grade serous ovarian cancers (LGSOC). 29157627 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.900 Biomarker disease BEFREE Analysis of the miRNA-mRNA-lncRNA network in human estrogen receptor-positive and estrogen receptor-negative breast cancer based on TCGA data. 29518546 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.900 Biomarker disease BEFREE This randomized, multicenter, international, phase II study enrolled postmenopausal women with advanced ER-positive breast cancer previously treated with a nonsteroidal aromatase inhibitor (NCT01234857). 28324268 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.900 AlteredExpression disease BEFREE A transcriptional complex composed of ER(α), GATA3, FOXA1 and ELL3 regulates IL-20 expression in breast cancer cells. 28514748 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.900 Biomarker disease BEFREE Nuclear estrogen receptor (ER), progesterone receptor (PR) and Ki-67 protein positive tumor cell fractions are semiquantitatively assessed in breast cancer for prognostic and predictive purposes. 28472544 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.900 Biomarker disease BEFREE Editor's Highlight: Transcriptome Profiling Reveals Bisphenol A Alternatives Activate Estrogen Receptor Alpha in Human Breast Cancer Cells. 28591870 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.900 AlteredExpression disease BEFREE The distribution pattern of ERα expression, ESR1 genetic variation and expression of growth factor receptors: association with breast cancer prognosis in Russian patients treated with adjuvant tamoxifen. 27225751 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.900 Biomarker disease BEFREE <b>Purpose:</b> Antiendocrine therapy remains the most effective treatment for estrogen receptor-positive (ER<sup>+</sup>) breast cancer, but development of resistance is a major clinical complication. 27702820 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.900 Biomarker disease BEFREE <b>Purpose:</b> Hyperactivation of AKT is common and associated with endocrine resistance in estrogen receptor-positive (ER<sup>+</sup>) breast cancer. 28874413 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.900 GeneticVariation disease BEFREE Upregulation of IRS1 Enhances IGF1 Response in Y537S and D538G ESR1 Mutant Breast Cancer Cells. 29029116 2018
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
0.900 Biomarker disease BEFREE Although the efficacy of tamoxifen (TAM) for breast cancer has been attributed to inducing cell cycle arrest and apoptosis by inhibiting estrogen receptor (ER) signaling, recent evidence indicates that TAM also possesses ER-independent antitumor activity through an unclear mechanism. 28724364 2018