Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE MiR-106b and miR-93 regulate cell progression by suppression of PTEN via PI3K/Akt pathway in breast cancer. 28518139 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE PTENP1 acts as a ceRNA to regulate PTEN by sponging miR-19b and explores the biological role of PTENP1 in breast cancer. 28731027 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 AlteredExpression disease BEFREE Various studies have evaluated the significance of PTEN (phosphatase and tensin homolog deleted from chromosome 10) expression in breast cancer, but their results remain controversial. 28410191 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE miR-93 and PTEN: Key regulators of doxorubicin-resistance and EMT in breast cancer. 28765915 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE Breast cancer risk and clinical implications for germline PTEN mutation carriers. 26700035 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE The genetic variants in the PTEN/PI3K/AKT pathway predict susceptibility and CE(A)F chemotherapy response to breast cancer and clinical outcomes. 28423632 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE MiRNA-21 induces epithelial to mesenchymal transition and gemcitabine resistance via the PTEN/AKT pathway in breast cancer. 26666820 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE Phosphatidylinositol 3-kinase regulatory subunit 1 and phosphatase and tensin homolog as therapeutic targets in breast cancer. 28351303 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE miR-222 induces Adriamycin resistance in breast cancer through PTEN/Akt/p27(kip1) pathway. 27699665 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE The prognostic value and potential drug target of phosphatase and tensin homolog in breast cancer patients: A meta-analysis. 28885360 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 PosttranslationalModification disease BEFREE Our findings indicated increased frequency of hypermethylation of PTEN promoter in the studied patients and their relatives that could be considered as one of the epigenetic factors affecting the risk of breast cancer in Iranians. 26715274 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE Addition of the p110α inhibitor BYL719 overcomes targeted therapy resistance in cells from Her2-positive-PTEN-loss breast cancer. 27639383 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 AlteredExpression disease BEFREE High PTEN gene expression is a negative prognostic marker in human primary breast cancers with preserved p53 function. 28213783 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE Benefit to neoadjuvant anti-human epidermal growth factor receptor 2 (HER2)-targeted therapies in HER2-positive primary breast cancer is independent of phosphatase and tensin homolog deleted from chromosome 10 (PTEN) status. 25851628 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE We generated cell lines resistant to the pan-PI3K inhibitor GDC-0941 from parental PTEN-null breast cancer cell lines and identified a novel PIK3CB D1067Y mutation in both cell lines that was recurrent in cancer patients. 26759240 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE PTEN Loss Is Associated with Worse Outcome in HER2-Amplified Breast Cancer Patients but Is Not Associated with Trastuzumab Resistance. 25649019 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE Loss of the tumor suppressor gene PTEN is implicated in breast cancer progression and resistance to targeted therapies, and is thought to promote tumorigenesis by activating PI3K signaling. 26929372 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE To date, the specific roles of IGFBP-2 in estrogen signalling are unclear, though there is accumulating evidence for an effect of IGFBP-2 on PI3K signalling via PTEN, particularly in breast cancer. 26522454 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE Four of the patients had breast cancer tissue available for PTEN immunohistochemistry, and all four patients' cancers were positive for PTEN. 25871911 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE Partial PTEN deletion is linked to poor prognosis in breast cancer. 26672755 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 AlteredExpression disease BEFREE Loss of PTEN protein expression occurs at high frequency in Middle Eastern breast cancer. 25981902 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 AlteredExpression disease BEFREE Bergapten drives autophagy through the up-regulation of PTEN expression in breast cancer cells. 26148846 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 AlteredExpression disease BEFREE Targets of miR-21 (TIMP3, PDCD4, PTEN, TPM1 and RECK) are also primarily involved in BC promotion and progression, especially invasion, angiogenesis and metastasis. miR-21 expression levels could perhaps be used in conjunction with the standard diagnostic parameters as an indicator of BC presence, and to indicate a phenotype likely to show early invasion/metastasis detection and poor prognosis. 26891730 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 GeneticVariation disease BEFREE AKT1, KRAS and PIK3CA mutations and PTEN loss all exist in women with breast cancer in the mainland China. 25816324 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.700 Biomarker disease BEFREE PTEN insufficiency modulates ER+ breast cancer cell cycle progression and increases cell growth in vitro and in vivo. 26316702 2016