Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE The purpose of this study was to retrospectively investigate the response to trastuzumab in breast cancer patients in terms of the potential roles of several oncogenic pathways (phosphatase and tensin homolog (PTEN) and phosphatidylinositol 3-kinase (PI3K)) in relation to HER2 status. 31786856 2020
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE PTEN loss mediates clinical cross-resistance to CDK4/6 and PI3Kα inhibitors in breast cancer. 31594766 2020
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 AlteredExpression disease BEFREE The data of previous studies reporting an important role of ERβ in tamoxifen sensitivity and our findings suggest down-regulation of ERβ triggered by PTEN knockdown contributed to the decreased response of breast cancer cells to tamoxifen observed in this study. 31604073 2020
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE We analyzed PTENP1 and PTEN levels in clinical BC samples and cell lines, and found that PTENP1 and PTEN were confirmed and closely correlated with the malignancy of BC cell lines and poor clinical prognosis. 31196157 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 AlteredExpression disease BEFREE In addition, the interaction of exogenous RILPL2 with TUBB3 resulted in the downregulation of BC cell proliferation and migration and upregulation of PTEN expression by promoting destabilization of TUBB3. 31497344 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 GeneticVariation disease BEFREE Opposite Prognostic Impact of Single PTEN-loss and <i>PIK3CA</i> Mutations in Early High-risk Breast Cancer. 31018950 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE Downregulation of microRNA-1469 promotes the development of breast cancer via targeting HOXA1 and activating PTEN/PI3K/AKT and Wnt/β-catenin pathways. 30320894 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE Our previous study indicated that MEOX1 is a critical molecular target in mesenchymal-like cancer cells in PTEN-deficient Trastuzumab resistant breast cancer. 30662330 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE Depleting Cdh1 accelerates breast cancer cell proliferation and cooperates with PTEN loss to promote breast tumor progression in mice. 31420536 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE Together, our data revealed that lncRNA MAGI2-AS3 is involved in breast cancer cell progression by regulating the miR-374a-PTEN axis. 30883342 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 GeneticVariation disease BEFREE The differences in immunophenotype between BRCA1- and BRCA2-deficient breast cancers can be attributed, in part, to PTEN gene mutation. 31022191 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 AlteredExpression disease BEFREE Further experiments showed Znhit1 affected BC through up-regulating PTEN, along with inactivation of the PI3K/Akt/mTOR pathway. 30928405 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 AlteredExpression disease BEFREE It seems that PTEN status determined by protein expression may discriminate between subgroups with poor and good prognosis in premenopausal HR-positive BC patients receiving adjuvant OA. 30358192 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 GeneticVariation disease BEFREE Germline DNA from 1054 BRCA-mutation-negative Hispanic women with hereditary BC (BC diagnosed at age <51 years, bilateral BC, breast and ovarian cancer, or BC diagnosed at ages 51-70 years with ≥2 first-degree or second-degree relatives who had BC diagnosed at age <70 years), 312 local controls, and 887 multiethnic cohort controls was sequenced and analyzed for 12 known and suspected, high-penetrance and moderate-penetrance cancer susceptibility genes (ataxia telangiectasia mutated [ATM], breast cancer 1 interacting protein C-terminal helicase 1 [BRIP1], cadherin 1 [CDH1], checkpoint kinase 2 [CHEK2], nibrin [NBN], neurofibromatosis type 1 [NF1], partner and localizer of BRCA2 [PALB2], phosphatase and tensin homolog [PTEN], RAD51 paralog 3 [RAD51C], RAD51D, serine/threonine kinase 11 [STK11], and TP53). 31206626 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 AlteredExpression disease BEFREE PTEN and MFN2 protein expressions were negative correlated with Vmax and positively correlated with RI in breast cancer patients. 31535669 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE In this perspective, glioblastoma U-87 MG and breast cancer MCF7 spheroids were generated to assess the therapeutic prospect of recombinant PTEN protein. 31290055 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE METABIRC and TCGA breast cancer cohort mRNA expression data analysis revealed that a high expression of the anti‑angiogenesis‑associated genes, THBS2, SERPINF1 and serpin family B member 5 (SERPINB5), and of the tumor suppressor gene, PTEN, was associated with a better overall survival (OS) of breast cancer patients. 31059004 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE We identified that YAP1 promotes cell growth and inhibits cell apoptosis of BC through the phosphatase and tensin homolog deleted on chromosome 10-AKT signaling pathway, and thus suggest that YAP1 might serve as a new target for inhibiting BC progression. 30868052 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 GeneticVariation disease BEFREE The PI3K/AKT pathway is activated through PIK3CA or AKT1 mutations and PTEN loss in breast cancer. 31277699 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE Regulation of AKT phosphorylation by GSK3β and PTEN to control chemoresistance in breast cancer. 31006103 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE Transgelin 2 Promotes Paclitaxel Resistance, Migration, and Invasion of Breast Cancer by Directly Interacting with PTEN and Activating PI3K/Akt/GSK-3β Pathway. 31488699 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE Correction: Trail Resistance Induces Epithelial-Mesenchymal Transition and Enhances Invasiveness by Suppressing PTEN via miR-221 in Breast Cancer. 30897152 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 GeneticVariation disease BEFREE However, the role of PTEN alterations in north Indian breast cancer 30678449 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 GeneticVariation disease BEFREE The most important cause of developing hereditary breast cancer is germline mutations occurring in breast cancer (BCs) susceptibility genes, for example, BRCA1, BRCA2, TP53, CHEK2, PTEN, ATM, and PPM1D. 30552672 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE The role of the phosphatase and tensin homolog status in predicting pathological complete response to neoadjuvant anti-HER2 therapies in HER2-positive primary breast cancer: A meta-analysis. 30702584 2019