Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
1.000 GeneticVariation disease BEFREE For both BRCA1 and BRCA2 mutation carriers, none of the smoking-related variables was associated with BC risk, except smoking for more than five years before a first full-term pregnancy (FFTP) when compared to parous women who never smoked. 31792088 2020
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
1.000 GeneticVariation disease BEFREE BRCA2 mutation carriers had a significantly higher frequency of CNS metastasis than noncarriers when controlling for breast cancer subtype. 31581314 2020
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
1.000 GeneticVariation disease BEFREE We have successfully identified a novel, germline heterozygous, missense mutation of the gene BRCA2: c.7007G>T, p.R2336L, which is likely to be pathogenic in the proband and her elder sister who both had breast cancer. 31782247 2020
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
1.000 GeneticVariation disease BEFREE Our study revealed a potential novel gene and multiple disruptive variants of BRCA2 for breast cancer risk, which may identify high-risk women in Chinese populations.This article is protected by copyright.All rights reserved. 31837001 2020
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
1.000 Biomarker disease BEFREE Eight PVs in ATM, BRCA2 (x2), PALB2, RAD51D, BRIP1, and MUTYH (x2) were identified in 7 of 44 individuals with breast cancer (15.9%, 95% CI: 7-30%), whereas none were identified in healthy controls (p = .01). 31575519 2020
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
1.000 GeneticVariation disease BEFREE Poly (ADP-ribose) polymerase (PARP) inhibitors exploit this deficiency through synthetic lethality and have emerged as promising anticancer therapies, especially in breast cancer gene (BRCA1 or BRCA2) mutation carriers. 31650446 2020
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
1.000 GeneticVariation disease BEFREE For BRCA mutation carriers, potential augmentation of already elevated breast cancer risk is of great concern. 30661763 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
1.000 GeneticVariation disease BEFREE Of 1054 BRCA-negative, high-risk Hispanic women, 4.5% carried a PV in a cancer susceptibility gene, increasing understanding of hereditary BC in this population. 31206626 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
1.000 GeneticVariation disease BEFREE We found that two polymorphic variants, rs1799967 (BRCA1) and rs4987117 (BRCA2), were strongly associated with the risk of BC. 30611917 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
1.000 AlteredExpression disease BEFREE Breast cancer type 1 and 2 susceptibility protein (BRCA1 and BRCA2) expression and <i>BRCA1/BRCA2</i> mRNA expression were evaluated using immunohistochemistry (IHC) and <i>in-situ</i> hybridization (ISH) on tissue GC microarray tissues, in addition to reverse transcription-quantitative polymerase chain reaction (RT-qPCR). 30988810 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
1.000 GeneticVariation disease BEFREE Mutations in two highly penetrance breast cancer susceptibility genes, BRCA1 and BRCA2, can only explain 20% to 25% of genetic susceptibility to breast cancer, and most familial breast cancer cases have intact BRCA1 and BRCA2 genes that refer to non-BRCA1/A2 or BRCAX familial breast cancer. 30125992 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
1.000 GeneticVariation disease BEFREE During the surveillance period, 5 individuals with BRCA1 or BRCA2 mutations were diagnosed with primary breast cancer. 30980249 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
1.000 Biomarker disease BEFREE Identification of candidate cancer predisposing variants by performing whole-exome sequencing on index patients from BRCA1 and BRCA2-negative breast cancer families. 30947698 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
1.000 GeneticVariation disease BEFREE Thousands of women in the USA would potentially benefit from genetic testing for BRCA1, BRCA2, and other breast cancer genes that markedly increase their risk of developing breast cancer. 30941656 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
1.000 GeneticVariation disease BEFREE Comparing the spectrum of BRCA1/2 mutation between KoOC and Korean breast cancer (KoBC) patients, the ratio of BRCA1-to-BRCA2 mutations was different, with BRCA1 (78.4%) being predominant in KoOC and BRCA2 in KoBC (59.2%). 30309222 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
1.000 GeneticVariation disease BEFREE The patient's son had been diagnosed with breast cancer 2.5 years ago and was found to have the same germline BRCA2 mutation. 31631483 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
1.000 GeneticVariation disease BEFREE Women who inherit a BRCA1 or BRCA2 mutation have an increased risk of breast cancer. 31407530 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
1.000 GeneticVariation disease BEFREE Mutations in BRCA1 and BRCA2 are the most prominent cause of breast cancer. 30188759 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
1.000 GeneticVariation disease BEFREE Folic acid supplement use and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a case-control study. 30603998 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
1.000 Biomarker disease BEFREE Because one of the early onset genes in breast cancer is the BRCA2, the presence of any of C and T alleles can have a significant effect on the incidence of the disease. 30706682 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
1.000 GeneticVariation disease BEFREE Most data were available for DDR panels (n=12 studies), ataxia telangiectasia mutated (ATM; n=13), breast cancer susceptibility gene (BRCA)1 (n=14) and BRCA2 (n=20). 31322208 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
1.000 GeneticVariation disease BEFREE Yet, while germline breast cancer susceptibility gene 1 (BRCA1) and breast cancer susceptibility gene 2 (BRCA2) testing is commonly performed, BRCA1/2 somatic mutations testing is rather challenging since the poor quality of DNA extracted from formalin fixed paraffin embedded (FFPE) samples can significantly impair this process. 30392916 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
1.000 GeneticVariation disease BEFREE These observations indicate that BRCA1/BRCA2 mutation carriers with ER-positive BC represent high-risk patients. 31141992 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
1.000 GeneticVariation disease BEFREE Clinically significant mutations of the BRCA1/BRCA2 genes are related to an increased susceptibility for breast cancer. 31228304 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
1.000 GeneticVariation disease BEFREE Clinically actionable BC susceptibility PVs, particularly in BRCA2 and CHEK2, were relatively prevalent among older women undergoing genetic testing. 31012959 2019