Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.600 GeneticVariation disease BEFREE Breast cancer risk in relation to TP53 codon 72 and CDH1 gene polymorphisms in the Bangladeshi women. 26666818 2017
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.600 GeneticVariation disease BEFREE Association of Genetic Polymorphisms in CDH1 and CTNNB1 with Breast Cancer Susceptibility and Patients' Prognosis among Chinese Han Women. 26285011 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.600 Biomarker disease BEFREE Clinicopathological significance and potential drug target of CDH1 in breast cancer: a meta-analysis and literature review. 26425077 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.600 Biomarker disease BEFREE miR-544a Promotes Breast Cancer Cell Migration and Invasion Reducing Cadherin 1 Expression. 27053345 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.600 Biomarker disease BEFREE E-, N-, P-, VE-, Proto-, desmosomal and FAT cadherins have been found to regulate breast cancer in positive as well as negative fashion, whereby both Ecadherin (CDH1) and N-cadherin (CDH2) contribute significantly towards transitioning from epithelial state to mesenchymal state (EMT) and enacting the abnormal cells to invade and metastasize nearby and distant tissues. 26825466 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.600 Biomarker disease BEFREE With mutational or epigenetic inactivation of the cell adhesion molecule E-cadherin (CDH1) being confined almost exclusively to ILC, this tumor entity stands out from all other types of breast cancers. 25757734 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.600 Biomarker disease BEFREE We found that the epithelial marker E-cadherin protein is higher in rapamycin sensitive (RS) cells and mesenchymal breast cancer cell lines selected by transcriptional EMT signatures are less sensitive to rapamycin. 25944619 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.600 AlteredExpression disease BEFREE Notch3 overexpression causes arrest of cell cycle progression by inducing Cdh1 expression in human breast cancer cells. 26694515 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.600 GeneticVariation disease BEFREE Breast cancer surveillance with annual breast MRI starting at age 30 for women with a CDH1 mutation is recommended. 25979631 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.600 AlteredExpression disease BEFREE Exogenous exposure to TGF-β1 was sufficient to drive the metastasis of an otherwise in situ model of BC and was similarly associated with a depletion and return of E-cad expression during metastatic progression. 24618085 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.600 AlteredExpression disease BEFREE Clinically, SIX2 expression correlated inversely with CDH1 expression in human breast cancer specimens, corroborating the disease relevance of their interaction. 25348955 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.600 Biomarker disease BEFREE Notwithstanding its relevance, how SLPI affects E-cadherin in breast cancer is still unknown. 25039920 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.600 PosttranslationalModification disease BEFREE δEF1 associates with DNMT1 and maintains DNA methylation of the E-cadherin promoter in breast cancer cells. 25315069 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.600 PosttranslationalModification disease BEFREE In contrast, 31 miRNAs were associated with E-cadherin promoter hypermethylation, which, contrary to E-cadherin mutation, is exclusively observed in breast cancer cell lines that are not of luminal origin. 23601657 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.600 GeneticVariation disease BEFREE Multiple DGC cases in a family, DGC at a young age in an individual or the combination of DGC andlobular breast cancer (LBC) in an individual or a family define the hereditary DGC syndrome (HDGC), and testing for germline CDH1 mutations is warranted in HDGC. 23709761 2014
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.600 Biomarker disease BEFREE An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation. 24292671 2014
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.600 Biomarker disease BEFREE Eligibility criteria included a deleterious germline mutation in BRCA1, BRCA2, CDH1, or TP53; lifetime breast cancer risk of ≥20 % as estimated by the Claus model; or personal history of estrogen receptor and progesterone receptor-negative breast cancer. 24166281 2014
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.600 GeneticVariation disease BEFREE The enrichment of ERBB2 mutations/fusion in CDH1-mutated ILC (5 of 22, 23%) compared with the 5 ERBB2 mutations in a series of 286 non-CDH1-mutated breast cancers from which the ILC cases were obtained (5 of 286, 2%) was significant (P = 0.0006). 23575477 2013
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.600 AlteredExpression disease BEFREE Sal-like 4 (SALL4) suppresses CDH1 expression and maintains cell dispersion in basal-like breast cancer. 23954296 2013
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.600 Biomarker disease CTD_human MCF-7 cells expressing nuclear associated lysyl oxidase-like 2 (LOXL2) exhibit an epithelial-to-mesenchymal transition (EMT) phenotype and are highly invasive in vitro. 24014025 2013
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.600 Biomarker disease CTD_human 3,5,4'-Trimethoxystilbene, a natural methoxylated analog of resveratrol, inhibits breast cancer cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchymal transition. 23921149 2013
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.600 Biomarker disease BEFREE We showed previously that breast cancer chemoprevention with benzyl isothiocyanate (BITC) in MMTV-neu mice was associated with induction of E-cadherin protein in vivo. 23276794 2013
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.600 AlteredExpression disease BEFREE The levels of miR-7 expression was positively correlated with E-CADHERIN mRNA and negatively correlated with VIMENTIN mRNA levels in breast cancer samples. 22876288 2013
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.600 Therapeutic disease CTD_human MCF-7 cells expressing nuclear associated lysyl oxidase-like 2 (LOXL2) exhibit an epithelial-to-mesenchymal transition (EMT) phenotype and are highly invasive in vitro. 24014025 2013
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.600 Therapeutic disease CTD_human 3,5,4'-Trimethoxystilbene, a natural methoxylated analog of resveratrol, inhibits breast cancer cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchymal transition. 23921149 2013