| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | Biomarker | disease | BEFREE | Elevated expression of miR-421 was evident, while Fgf10 was poorly expressed in BPD. upregulation of miR-421 and silence of Fgf10 aggravated inflammatory response in lung tissue and promoted lung cell apoptosis in BPD. | 31144392 | 2019 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | Finally, we evaluated changes in FGF10, surfactant protein C (SFTPC), platelet endothelial cell adhesion molecule (PECAM) and alpha-smooth muscle actin 2 (α-SMA) expression in human lung samples from patients suffering from BPD. | 30566624 | 2019 | ||||
|
0.070 | Biomarker | disease | BEFREE | <i>Fgf10</i> signaling is dysregulated in different human lung diseases including bronchopulmonary dysplasia (BPD), idiopathic pulmonary fibrosis (IPF), and chronic obstructive pulmonary disease (COPD), suggesting that dysregulation of the FGF10 pathway is critical to the pathogenesis of several human lung diseases. | 30319693 | 2018 | ||||
|
0.070 | Biomarker | disease | BEFREE | Here we review the cellular and molecular mechanisms linking FGF10 to multiple lung diseases, from bronchopulmonary dysplasia in extremely preterm neonates, cystic fibrosis in children, and chronic adult lung disorders. | 30429870 | 2018 | ||||
|
0.070 | Biomarker | disease | BEFREE | Thus, to investigate the protective effects of FGF-10 on hyperoxia induced BPD in neonatal mice will provide a new strategy for the treatment of BPD. | 28861146 | 2017 | ||||
|
0.070 | Biomarker | disease | BEFREE | Fgf10 deficiency is causative for lethality in a mouse model of bronchopulmonary dysplasia. | 27770432 | 2017 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | Reduced FGF-10 expression may therefore link the innate immune system and impaired lung development in bronchopulmonary dysplasia. | 17071719 | 2007 |