Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.400 GeneticVariation disease BEFREE A high Ki-67 proliferation index and positive bcl-2 staining (on cytospin slides or cell block material) of cases not conforming to typical Burkitt lymphoma morphology should prompt FISH analysis for c-MYC and/or IGH-BCL2 rearrangements to identify DHL, particularly if tissue biopsy is not expected. 21560252 2011
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.400 GeneticVariation disease BEFREE Patients demonstrating a terminal deoxynucleotidyl transferase (TdT)-positive precursor B cell phenotype with IGH-MYC rearrangement have been reported to be molecularly distinct from BL and closer to B-ALL/LBL. 31705772 2020
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.400 GeneticVariation disease BEFREE B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements are aggressive neoplasms with clinical and pathologic features distinct from Burkitt lymphoma and diffuse large B-cell lymphoma. 20118770 2010
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.400 GeneticVariation disease BEFREE The chromosomal translocation t(8;14)(q24;q32) with juxtaposition of MYC to enhancer elements in the immunoglobulin heavy chain (IGH) gene locus is the genetic hallmark of the majority of Burkitt lymphoma and a subset of Diffuse large B-cell lymphoma patients. 23673335 2013
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.400 GeneticVariation disease BEFREE We performed a polymerase chain reaction analysis of three regions of the VDJ junction of the immunoglobulin heavy chain (IGH) gene and compared the clonality of the first and second BL lesions, which were found to be clonally distinct. 25555480 2015
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.400 GeneticVariation disease BEFREE The DNA sequence of the third-complementarity-determining region (CDRIII) of the immunoglobulin heavy chain (IgH) gene in a case of Burkitt's lymphoma was determined by polymerase chain reaction (PCR) using template DNA extracted from a smear stored at room temperature for more than one year. 1908851 1991
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.400 GeneticVariation disease BEFREE The chromosomal translocation t(8;14) is the hallmark of Burkitt's-lymphoma (BL) and fuses the proto-oncogene c-MYC to the IGH locus. 17541401 2007
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.400 GeneticVariation disease BEFREE Thus, the capacity of Tat to spontaneously penetrate B-cells could be sufficient to favor the occurrence of MYC-IGH oncogenic rearrangements during erroneous repair, a plausible cause for the increased incidence of Burkitt lymphoma in the HIV-infected population. 30701532 2019
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.400 GeneticVariation disease BEFREE Cryptic insertion of <i>MYC</i> exons 2 and 3 into the IGH locus detected by whole genome sequencing in a case of MYC-negative Burkitt lymphoma. 31073073 2019
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.400 GeneticVariation disease BEFREE We have molecularly characterized the recently established Burkitt lymphoma cell line BLUE-1 that carries a t(6;20)(q15;q11.2) rearrangement in addition to the typical t(8;14) with MYC-IGH fusion. 21412927 2011
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.400 Biomarker disease BEFREE Oligonucleotide sets that probe breakpoints of <i>IGH-BCL2</i> (immunoglobulin heavy-apoptosis regulator) in follicular lymphoma (FL), <i>MYC-IGH</i> (MYC proto-oncogene, bHLH transcription factor-immunoglobulin heavy) in Burkitt lymphoma (BL) and <i>BCR-ABL1</i> (RhoGEF and GTPase activating protein-ABL proto-oncogene 1, non-receptor tyrosine kinase) in chronic myelogenous leukemia (CML) were designed. 28515100 2017
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.400 Biomarker disease BEFREE IGH switch breakpoints in Burkitt lymphoma: exclusive involvement of noncanonical class switch recombination. 16736499 2006
Entrez Id: 3492
Gene Symbol: IGH
IGH
0.400 SomaticCausalMutation disease ORPHANET Presence of more than two rearranged immunoglobulin heavy-chain genes in adult precursor B-cell acute lymphoblastic leukemia. 1554798 1992