Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5079
Gene Symbol: PAX5
PAX5
0.350 Biomarker disease BEFREE We identified 76 genes essential to Burkitt lymphoma, including genes associated with hematopoietic cell differentiation (<i>FLI1, BCL11A</i>) or B-cell development and activation (<i>PAX5, CDKN1B, JAK2, CARD11</i>) and found a number of context-specific dependencies including oncogene addiction in cell lines with <i>TCF3</i>/<i>ID3</i> or <i>MYD88</i> mutation. 31000522 2019
Entrez Id: 5079
Gene Symbol: PAX5
PAX5
0.350 SusceptibilityMutation disease ORPHANET A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia. 24013638 2013
Entrez Id: 5079
Gene Symbol: PAX5
PAX5
0.350 FusionGene disease ORPHANET PAX5-AUTS2: a recurrent fusion gene in childhood B-cell precursor acute lymphoblastic leukemia. 22578776 2012
Entrez Id: 5079
Gene Symbol: PAX5
PAX5
0.350 FusionGene disease ORPHANET FOXP1 and PAX5 are rare but recurrent translocations partners in acute lymphoblastic leukemia. 21962897 2011
Entrez Id: 5079
Gene Symbol: PAX5
PAX5
0.350 Biomarker disease BEFREE Burkitt lymphoma cases were positive for PAX5 (30/30 [100%]), BOB.1 (27/30 [90%]), PU.1 (23/30 [77%]), CD79a (29/30 [97%]), CD22 (14/30 [47%]), CD20 (30/30 [100%]), OCT-2 (23/30 [77%]), and MUM1 (5/30 [17%]). 20023257 2010
Entrez Id: 5079
Gene Symbol: PAX5
PAX5
0.350 FusionGene disease ORPHANET After cloning the full-length cDNA of the chimeric gene, confocal microscopy of transfected NIH3T3 cells and Burkitt lymphoma cells (DG75) demonstrated that PAX5-ELN was localized in the nucleus. 17179230 2007
Entrez Id: 5079
Gene Symbol: PAX5
PAX5
0.350 Biomarker disease BEFREE After cloning the full-length cDNA of the chimeric gene, confocal microscopy of transfected NIH3T3 cells and Burkitt lymphoma cells (DG75) demonstrated that PAX5-ELN was localized in the nucleus. 17179230 2007
Entrez Id: 5079
Gene Symbol: PAX5
PAX5
0.350 AlteredExpression disease BEFREE ID2 was also expressed in lymphocyte-predominance HL, mediastinal large B-cell, diffuse large B-cell, and Burkitt's lymphoma, where lower amounts of ID2 relative to E2A and PAX5 compared with HRS cells might prevent a global down-regulation of B-cell-specific genes and ID2 may contribute to lymphomagenesis in other ways. 16877363 2006
Entrez Id: 5079
Gene Symbol: PAX5
PAX5
0.350 AlteredExpression disease BEFREE Pax5 was strongly expressed in most of the B cell lymphomas; 44 of 47 diffuse large B cell lymphomas (93.6%), 15 of 16 marginal zone B cell lymphomas (93.8%), all 3 mantle cell lymphomas, 2 follicular lymphomas, and 2 Burkitt's lymphomas (100%). 14676435 2003