Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker group BEFREE Together, these data suggest that inhibition of FGFR2 may be a viable therapeutic option in endometrial tumors possessing activating mutations in FGFR2, despite the frequent abrogation of PTEN in this cancer type. 18757403 2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation group BEFREE Inactivation of the PTEN/MMAC1 tumor suppressor gene has been linked to tumor progression in several human malignancies. 12011252 2002
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation group BEFREE Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a well-known tumor suppressor that acts as a dual-specificity phosphatase and is frequently mutated in human cancer. 29057971 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker group BEFREE PTEN testing and intensive cancer surveillance allow for early detection and treatment of these cancers for mutation-positive patients and their relatives. 27033071 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker group BEFREE Phosphatase and tensin homolog (PTEN) has been frequently reported to affect chemo-sensitivity of cancers, and usually acts as a tumor suppressor. 28686971 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker group BEFREE Germline mutations in PTEN are associated with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) hamartoma tumor syndrome including Cowden syndrome (CS) and Cowden-like syndrome (CSL) that predisposes to high risks of benign and malignant tumors of thyroid and breast. 22962422 2012
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker group BEFREE DJ-1 is thus a key negative regulator of PTEN that may be a useful prognostic marker for cancer. 15766664 2005
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker group BEFREE These data suggest that PTEN may safeguard against developing malignant tumors in patients with TSC deficiency. 19648120 2009
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker group BEFREE These findings suggest that PTEN suppresses the cell growth through modulation of IGF system and sensitizing cancer cells to cell death by anticancer drugs. 16264263 2005
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker group BEFREE Metabolic reprogramming induced by PTEN loss fuels malignant growth and proliferation of prostate cancer cells. 30854061 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker group BEFREE Although somatic mutations in the PI3K pathway genes PIK3CA and PTEN are known to drive PI3K pathway activation and cancer growth, the significance of somatic mutations in other PI3K pathway genes is less clear. 25982275 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation group BEFREE Patients with germline PTEN mutations are at high risk of developing benign and malignant tumours. 23934601 2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 AlteredExpression group BEFREE Overall PTEN expression was associated with the anatomical region of the malignancies (p=0.039), whereas a borderline correlation with the differentiation grade was also assessed (p=0.05). 28982865 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker group BEFREE DJ-1 can induce the tumor cell proliferation and invasion via down-regulating PTEN in many malignant tumors, and correlated to prognostic significance. 23151319 2012
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation group BEFREE PTEN IVS4 (-/-) genotype was significantly associated with increased risk of cancer especially for digestive tract cancer compared to the (+/+) genotype. 26417029 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker group BEFREE Much evidence has proven BTG2, PPP1CA, and PTEN act as tumor suppressor genes in many malignancies. 30912184 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation group BEFREE Cowden disease is a genetic disorder associated with a mutation of the PTEN gene and is known to be easily complicated by generalized vascular malformations and malignant tumors. 29636101 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker group BEFREE The protein phosphatase and tensin homolog (PTEN) is inactivated in a wide range of human cancers, an alteration that is associated with a poor prognosis. 19492080 2009
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation group BEFREE Phosphatidylinositol 3,4,5-trisphosphate RAC exchanger 2a (P-REX2a) activates the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) signaling pathway by binding to and inactivating phosphatase and tensin homolog (PTEN), which functions as a tumor promoter in a number of types of cancer. 29435055 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker group BEFREE Focused analysis of target genes of four therapy-responsive circulating miRNAs, identified in a previous study on HNSCC patients, revealed a major impact on the pathways direct P53 effectors, the E2F transcription factor network and pathways in cancer (mainly represented by the PTEN/AKT signaling pathway). 26328888 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 AlteredExpression group BEFREE Evaluation of expression of PTEN gene may turn out to be a very useful tool aimed at qualifying patients for different therapies of endometrial cancer and at searching of new diagnostic and therapeutic methods of this cancer independently on its receptor status nor maturity grade of cancer. 24030769 2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 AlteredExpression group BEFREE In contrast to everolimus, MC-4 enhanced phosphatase and tensin homolog expression and reduced its downstream effector, Akt/pyruvate kinase muscle isozyme M2 (PKM2), leading to decreased expression of glucose transporter 1, which is associated with cancer cell metabolism. 30160042 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation group BEFREE It is well-known that estrogen plays an important role in the pathogenesis of endometrioid endometrial carcinoma (EEC), and induces the cancer suppressor gene PTEN deletion. 30584245 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 Biomarker group BEFREE The tumor suppressor phosphatase and tensin homolog (PTEN) negatively regulates phosphatidylinositol 3-kinase (PI3K)-AKT signaling and is often inactivated by mutations (including deletions) in a variety of cancer types, including T-cell acute lymphoblastic leukemia. 27582570 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.400 GeneticVariation group BEFREE Moreover, high-level HDAC1 staining was associated with TMPRSS2:ERG rearrangement and ERG expression in prostate cancers (p<0.0001) and was linked to deletions of PTEN (p<0.0001), 6q (p<0.0001) and 5q (p=0.0028) in ERG-negative cancers. 25794974 2015