Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE <i>EGFR</i> mutations in cfDNA, both the activating mutation and <i>EGFR</i> T790M, became undetectable in most patients in the setting of clinical response and reemerged upon disease progression.<b>Conclusions:</b> ASP8273 was well tolerated and promoted antitumor activity in patients with <i>EGFR</i>-mutant lung cancer with disease progression on prior EGFR TKI therapy.<i>Clin Cancer Res; 23(24); 7467-73.©2017 AACR</i>. 28954786 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE The kinase domain of EGFR is highly conserved in whole gastric cancer cell lines and cases, therefore treatment with gefitinib is unfortunately not recommended for such malignancy. 16353180 2006
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE Mutations of EGFR were identified in 2 (40%) of 5; these mutations have been previously reported in cancer but did not affect classic activation hotspot sites. 27067779 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE These results have significant implications for the use of such tools in personalizing the approach to cancers treated with EGFR-directed targeted therapies. 19881954 2009
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE The current diagnostic test measures the overall EGFR mutation status of the cancer tissue, and may ignore the presence of non-mutated, gefitinib-unresponsive cancer cells. 18325048 2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE These results highlight the differentiated potential of JNJ-61186372 to inhibit the spectrum of mutations driving EGFR TKI resistance in NSCLC.Cancer Res; 76(13); 3942-53.©2016 AACR. 27216193 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE We apply s-RT-MELT in the screening of p53 and EGFR mutations in cell lines and clinical samples and demonstrate its advantages for rapid, multiplexed mutation scanning in cancer and for genetic variation screening in biology and medicine. 17545195 2007
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE Deregulated activation of protein tyrosine kinases, such as the epidermal growth factor receptor (EGFR) and Abl, is associated with human cancers including non-small cell lung cancer (NSCLC) and chronic myeloid leukemia (CML). 20026060 2010
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE Moreover, these findings strengthen the rationale for determining whether inhibitors of COX-2 or EGFR tyrosine kinase activity can reduce the risk of tobacco smoke-related malignancies of the aerodigestive tract. 15695412 2005
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE Activation of signaling by the epidermal growth factor receptor (EGFR) through gene amplification or rearrangement is common in human malignancy, especially in a large fraction of de novo glioblastomas multiforme (GBMs). 11565870 2001
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE While they produce dramatic responses in a subset of patients-primarily those with activating EGFR mutations-remissions are typically limited to several months due to acquired drug resistance, frequently associated with the secondary T790M mutation in EGFR.In this issue of Cancer Cell, Li et al. report that an irreversible EGFR kinase inhibitor, HKI-272, had limited activity in a mouse lung cancer model driven by an EGFR mutant harboring T790M and an activating mutation. 17613432 2007
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE To study the ALK translocation in patients with advanced non-small-cell lung carcinomas (NSCLCs) seen at a European cancer centre, and its association with EGFR mutations, KRAS mutations and MET amplification. 23379755 2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE The occurrence of amplification and rearrangements at the EGFR gene locus is associated with malignancy in neuroepithelial tumours. 1447576 1992
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE A differentially expressed gene set between engrafting and nonengrafting patients could identify patients harboring EGFR-mutant tumor with significantly different prognoses in The Cancer Genome Atlas Lung Adenocarcinoma datasets. 26124487 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE EGFR and ERBB2 Germline Mutations in Chinese Lung Cancer Patients and Their Roles in Genetic Susceptibility to Cancer. 30610926 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have become the standard first-line treatment for advanced lung adenocarcinoma (LUAD) cancer patients with activating EGFR mutations. 30382076 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE We showed that mTOR and phosphodiesterase 4D (PDE4D) strongly correlate in resistant EGFR-mutant cancer cell lines. 26639561 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE Two T790-wild-type cancers underwent small cell lung cancer transformation; three T790M-positive cancers acquired EGFR amplification. 25934077 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE Three studies on target therapies showed that several cases of thymic malignancies were reported to have partial response (PR) to epidermal growth factor receptor tyrosine kinase inhibitors such as cetuximab and erlotinib, whereas, one study on erlotinib and another on gefitinib showed no activity. 25754373 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE Oncogenic activations by mutations in key cancer genes such as EGFR and KRAS are frequently associated with human cancers. 26645892 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling. 21734175 2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE Epidermal growth factor receptor (EGFR) intron 1 has a polymorphic region of CA repeats that is believed to be associated with increased EGFR expression, tumor aggressiveness, and worse survival in cancer patients. 20409526 2010
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE Data from the current study suggest that EGFR mutations in concert with P53 mutations accelerate cancer development and lead to evolution of therapeutic resistance. 23026641 2012
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE In a cohort of 93 breast cancer metastatic patients, cmDetect identified ctDNA mutations in 54% of the patients and recovered somatic mutations in cancer genes EGFR, PIK3CA, and TP53 We further showed that cmDetect detected ctDNA in 89% of patients with confirmed mutated cell-free tumor DNA by plasma analyses (n = 9) within 46 pan-cancer patients. 27535334 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation group BEFREE Putative lung adenocarcinoma presenting as CUP may have EGFR mutation, and EGFR-TKI therapy may be effective for such malignancy. 29443782 2018