Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 Biomarker group BEFREE In addition, NO has other multiple synergistic cancer treatment functions, including tumor tissue vasodilatation for drug extravasation promotion, P-glycoprotein (P-gp) downregulation for drug efflux inhibition, and glutathione depletion for cancer cell endogenous antioxidant defense destruction. 31804837 2020
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 Biomarker group BEFREE Overexpression of ATP-binding cassette subfamily B member 1 (ABCB1)-encoded multidrug resistance protein 1 (MDR1) constitutes a major mechanism of cancer drug resistance including docetaxel (DTX) and cabazitaxel (CTX) resistance in castration-resistant prostate cancer (CRPC). 31712394 2020
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 Biomarker group BEFREE The kinetic of P-glycoprotein-mediated efflux pirarubicin was used to monitor P-glycoprotein function in multidrug resistant (MDR) cancer cells. 30924055 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 Biomarker group BEFREE Overexpression of ATP-binding cassette (ABC) transporters, such as ABCB1 and ABCG2, has been proved to be a major trigger for multidrug resistance (MDR) in certain types of cancer. 31472682 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 Biomarker group BEFREE The link between bacterial and viral infections to cancer compels us to highlight fascinating reports from coumarin isolation from microorganisms; comment on the recent bioavailability studies of natural or derived coumarins; and discuss our perspectives with respect to bioisosterism in coumarins, p-glycoprotein inhibition and covalent modification, and bioprobes. 31140865 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 GeneticVariation group BEFREE Multidrug resistance to anticancer drugs, which is often associated with enhanced expression of the ATP‑binding cassette (ABC) transporter P‑glycoprotein (encoded by the ABCB1 gene) may limit the effects of cancer therapy. 31173253 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 Biomarker group BEFREE Although nanodrugs have been shown to evade P-glycoprotein (P-gp) recognition and reverse multi-drug resistance (MDR) in cancer, a specific mechanism of how nanodrugs reverse MDR is still unclear. 31282916 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 AlteredExpression group BEFREE Multidrug resistance (MDR) in cancer cells is often associated with overexpression of ATP-binding cassette (ABC) transporters, including P-glycoprotein (P-gp/ABCB1), multidrug resistance-associated protein 1 (MRP1/ABCC1) and breast cancer resistance protein (BCRP/ABCG2). 30391378 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 GeneticVariation group BEFREE The aim of this study was to evaluate the association between OPRM1 and ABCB1 polymorphisms on pain relief with epidural sufentanil in 69 patients after rectosigma resection for cancer. 31755291 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 AlteredExpression group BEFREE In this study, we demonstrated that EBV latent infection induced intracellular ROS production and increased ROS levels triggered elevated P-gp expression, which resulted in strong resistance to existing anti-cancer drugs in EBV-positive lymphoma cell lines and in patients' tissue samples. 30972167 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 Biomarker group BEFREE Pharmacophoric features for a very potent 5-spirofluorenehydantoin inhibitor of cancer efflux pump ABCB1, based on X-ray analysis. 30586228 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 AlteredExpression group BEFREE Resistance to chemotherapeutic drugs in cancer cells is frequently associated with high expression of p-glycoprotein, a transporter in the plasma membrane that can mediate cellular drug export. 30312727 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 Biomarker group BEFREE Furthermore, multidrug resistance protein 1 (MDR1) expression in k562/dox cells was downregulated by levistolide A in a dose‑dependent manner, thus suggesting that levistolide A may modulate MDR1 during cancer therapy. 30483812 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 Biomarker group BEFREE The ATP-binding cassette transporter G2 (ABCG2; also known as breast cancer resistance protein, BCRP) has been suggested to be involved in clinical multidrug resistance (MDR) in cancer like other ABC transporters such as ABCB1 (<i>P</i>-glycoprotein). 30890942 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 Biomarker group BEFREE Sulfocoumarins, specific carbonic anhydrase IX and XII inhibitors, interact with cancer multidrug resistant phenotype through pH regulation and reverse P-glycoprotein mediated resistance. 31330259 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 Biomarker group BEFREE Among these exporters, P-glycoprotein and MRP1 are involved in cancer multidrug resistance, protection from endo and xenobiotics, determination of drug pharmacokinetics, and the pathophysiology of a variety of disorders. 29022498 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 Biomarker group BEFREE One of the most widely used drugs, doxorubicin (Dox) is a substrate of three different ATP-binding cassette (ABC) transporters, namely, ABCB1, ABCG2 and ABCC1, predominantly contributing to MDR phenotype in cancer. 30221549 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 Biomarker group BEFREE Selectivity toward cancer cells and interaction with P-glycoprotein of the active withanolides were evaluated. 31070367 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 Biomarker group BEFREE The present study demonstrated that ZA-A, ZA-B and ZA-C, popular triterpenoids from T. camphoratus, effectively modulated the drug efflux transporter P-gp and reversed the cancer MDR issue. 31766413 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 AlteredExpression group BEFREE Overexpression of P-gp in tumor cells is a major obstacle in cancer chemotherapy. 30270513 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 AlteredExpression group BEFREE Multidrug resistance is a major cause of failure in the clinical cancer therapy, in which the overexpression of P-glycoprotein (P-gp) plays a crucial role. 31403276 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 Biomarker group BEFREE P-glycoprotein (P-gp) is a multidrug transporter, which harnesses the chemical energy of ATP to power the efflux of diverse chemotherapeutics out of cells and thus contributes to the development of multidrug resistance (MDR) in cancer. 30899446 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 Biomarker group BEFREE Chk1 Inhibitor MK-8776 Restores the Sensitivity of Chemotherapeutics in P-glycoprotein Overexpressing Cancer Cells. 31443367 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 Biomarker group BEFREE Out of the eleven screened potent inhibitors, compound (8) exhibited the excellent bioavailability radar against the six molecular descriptors, good absorption, distribution, metabolism and excretion properties along with P-glycoprotein, CYP450 isozymes and membranes permeability profile, on the basis of these factual observations compound (8) can be predict to get in-vivio experimental clearance efficiently, Therefore in future it can be a drug in market, to treat the various disorders associated with the over expression of β-Glucuronidase, enzyme including various types of cancers, particularly hormone-dependent cancers such as (breast, prostate, and colon cancer), while other compounds (1-7, & 9-11), are also showing good predictive pharmacokinetics, medicinal chemistry , BBB and HIA membranes permeability profiles with the requirement of slight lead optimization to get the improved and enhance results. 30894110 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.400 Biomarker group BEFREE Overexpression of ABC transporters like P-glycoprotein (P-gp) has been correlated with resistances in cancer chemotherapy. 31702922 2019