Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker group BEFREE The PIK3 CA gene encodes the p110α protein subunit and is one of the most efficient cancer genes in solid and hematological tumors including hepatocellular carcinoma (HCC). 31668943 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker group BEFREE Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis indicated that target genes of upregulated miRNAs were enriched in pathways in cancer, microRNAs in cancer and proteoglycans in cancer, while the target genes of downregulated miRNAs were mainly associated with pathways in cancer, the PI3K-Akt signaling pathway and HTLV-I infection. 31692035 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker group BEFREE Here we discuss our current understanding of the molecular events controlling cellular metabolism downstream of PI3K and AKT and of how these events couple two major hallmarks of cancer: growth factor independence through oncogenic signalling and metabolic reprogramming to support cell survival and proliferation. 31686003 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker group BEFREE Concomitant inhibition of PARP and PI3K pathways has been recognized as a promising strategy for cancer therapy, which may expand the clinical utility of PARP inhibitors. 31846325 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker group BEFREE Modulation of cell signaling pathways, such as those involving mitogen activated protein kinases (MAPKs), nuclear factor kappa β (NF-κB), phosphatidylinositol 3-kinase and protein kinase B (PI3K/Akt), and Wnt, and their outcomes play a fundamental role in inflammation and cancer. 31792765 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 AlteredExpression group BEFREE In contrast, midkine (MK), a heparin-binding growth factor and cytokine, which induces carcinogenesis and chemoresistance, promotes the development and progression of many malignant tumours by increasing diverse cell functions such as cell proliferation, cell survival and antiapoptotic activities via mainly the activation of phosphatidyl inositol 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) pathways. 31634770 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker group BEFREE Potential anti-cancer effects of metformin in gynecologic malignancies include inhibition of the PI3K-mTOR pathway, hormone receptor regulation and decrease of fibrosis and inflammation-multiple studies are currently assessing its role in cancer prevention and as a treatment enhancer. 31772118 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 AlteredExpression group BEFREE ACLY plays a pivotal role in cancer metabolism through the potential deprivation of cytosolic citrate, a process promoting glycolysis through the enhancement of the activities of PFK 1 and 2 with concomitant activation of oncogenic drivers such as PI3K/AKT which activate ACLY and the Warburg effect in a feed-back loop. 31830561 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 GeneticVariation group BEFREE The class I phosphoinositide 3-kinases (PI3Ks) are key signaling enzymes composed of a heterodimer of a p110 catalytic subunit and a p85 regulatory subunit, with PI3K mutations being causative of multiple human diseases including cancer, primary immunodeficiencies, and developmental disorders. 31831213 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 AlteredExpression group BEFREE As a result, many cancers with high PI3K pathway activity, such as triple-negative breast cancer (TNBC), are treated primarily with chemotherapy. 31812693 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker group BEFREE Distinct roles of PIK3CA in the enrichment and maintenance of cancer stem cells in head and neck squamous cell carcinoma. 31600013 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker group BEFREE Here we provide a comprehensive review of the current knowledge on SOX2 protein modifications, their proposed relationship to the PI3K/AKT pathway, and regulatory influence on SOX2 with regards to stemness, reprogramming, and cancer. 31477842 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker group BEFREE In this study, we assessed the expression of LETM1 along with the genes related to cancer stemness, cell cycle, and PI3K/Akt signaling in 189 paraffin-embedded GA tissue samples and GA-derived cell lines using immunohistochemistry (IHC), western blotting, and immunofluorescence. 31705880 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker group BEFREE Targeting both CD20 and phosphatidylinositol 3-kinase (PI3K), a protein that is critically involved in B-cell maturation, could be an efficacious strategy for treating B-cell malignancies. 31558467 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker group BEFREE The main target of <i>PTEN</i> phosphatase activity is one of the most significant cell growth and pro-survival signaling pathway in cancer: PI3K/AKT/mTOR. 31366089 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker group BEFREE The PI3K/Akt signaling, a well-known carcinogenic signaling pathway in human cancer, cooperates with other signaling pathways such as Wnt signaling to promote cancer progression. 31601147 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker group BEFREE Targeted therapy using phosphatidylinositol 3-kinase (PI3K) inhibitors is used to treat cancer such as lymphoma. 31250153 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker group BEFREE The pathways in cancer, phosphoinositide 3-kinases (PI3K)-Akt signaling, Hippo signaling, and proteoglycans, are highly enriched in high-risk groups by GSEA. 31632439 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker group BEFREE Likewise, repurposing PI3K pathway inhibitors that are currently in cancer clinical trials can be used as a novel strategy for the treatment of these diseases. 30855339 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker group BEFREE As examples, the role of phosphoinositide 3 kinase/Akt/ mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway in cell cycle re-entry and blocking autophagy are discussed as potential common intracellular components between AD and cancer pathogenesis, with diverse clinical diagnosis. 30881282 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker group BEFREE JQ1 and PI3K inhibition synergistically reduce salivary adenoid cystic carcinoma malignancy by targeting the c-Myc and EGFR signaling pathways. 30269363 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 AlteredExpression group BEFREE We recently reported the development and biological validation of a test that provides a quantitative PI3K pathway activity score for individual cell and tissue samples across cancer types, based on measuring Forkhead Box O (FOXO) transcription factor target gene mRNA levels in combination with a Bayesian computational interpretation model. 30832253 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker group BEFREE The miRNA microarray analysis results suggested that several potential pathways related to cancer development: the RhoA pathway, the PI3K-Akt signalling pathway and the MAPK signalling pathway. 30927432 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker group BEFREE Previous studies suggest that T-cell malignancies are usually accompanied by highly activated PI3K/AKT signaling which confers the ability of cancer cells to proliferate and survive. 31560953 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker group BEFREE The downregulated genes were significantly enriched in cGMP-PKG signaling pathway and calcium signaling pathway whereas the upregulated genes were enriched in pathways in cancer and PI3K-Akt signaling pathway. 30971889 2019