Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 Biomarker group BEFREE Mutation analysis of tumor suppressor gene PTEN in patients with gastric carcinomas and its impact on PI3K/AKT pathway. 20514448 2010
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 GeneticVariation group BEFREE PIK3CA mutations occurred in 2 (2/13, 15%) ambiguous carcinomas and PTEN mutations in 1 (1/7, 14%) mixed and 1 (1/13, 8%) ambiguous carcinoma. 26975040 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 Biomarker group BEFREE The PTEN gene is involved in 10q23 deletions in several types of cancer, including glioma, melanoma, endometrial and prostate carcinomas. 10092130 1999
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 AlteredExpression group BEFREE We assessed the relationship between ERG and PTEN protein expression in cribriform architecture prostatic carcinomas and adjacent acinar non-cribriform carcinoma and determined the interobserver variability in assessment of these markers. 27913052 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 AlteredExpression group BEFREE The present study has assessed the in situ expression of PTEN mRNA and protein in 26 prostate intraepithelial neoplasias (PINs), 58 primary prostate carcinomas, and 15 metastases. 15095479 2004
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 AlteredExpression group BEFREE Loss of PTEN function has been implicated in the progression of several types of cancer, but the correlation between loss of PTEN expression and advanced carcinomas is not well established. 14674989 2004
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 Biomarker group BEFREE However, little is known about the profile of PTEN gene in oral carcinomas. 18497947 2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 GeneticVariation group BEFREE Thus, inactivation of the PTEN gene by homozygous deletion occurs in approximately 10-15% of primary stage B prostate carcinomas. 9533551 1998
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 Biomarker group BEFREE Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in advanced gastric carcinomas. 12695913 2003
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 GeneticVariation group BEFREE CGH analysis demonstrated that all four tumors (100%) showed chromosomal copy number loss around the locus of this gene, whereas four (57%) of seven tumors with PTEN/MMAC1 mutations showed chromosomal loss or double mutations in MI- carcinomas. 11585417 2001
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 Biomarker group BEFREE To evaluate the role of PTEN in other common malignancies of the female genital tract, 12 serous ovarian carcinomas and 10 squamous cervical carcinomas were analyzed and were negative for mutations. 9307275 1997
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 GeneticVariation group BEFREE Mutation or deletion of PTEN has been observed in a proportion of prostate cancer cell lines; however, primary prostate carcinomas have not been studied. 9582022 1998
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 AlteredExpression group BEFREE Immunohistochemical analyses of ER expression in mammary carcinomas arising in PTEN heterozygous knockout mice did not demonstrate a reduction in ER immunoreactivity, in comparison to wild-type mice. 12569575 2003
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 Biomarker group BEFREE Loss of PTEN protein was found in thyroid adenomas and carcinomas from all 22 (100%) PTEN(Mut+) CS/CSL patients. 22962422 2012
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 Biomarker group BEFREE Molecular alterations of EGFR and PTEN in prostate cancer: association with high-grade and advanced-stage carcinomas. 20208477 2010
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 AlteredExpression group BEFREE Longstanding molecular observations implicate PTEN inactivation as a major driver of endometrioid carcinomas; TP53 inactivation as a major driver of most serous carcinomas, some high-grade endometrioid carcinomas, and many uterine carcinosarcomas; and inactivation of either gene as drivers of some clear cell carcinomas. 30332563 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 Biomarker group BEFREE Finally, we found a high frequency of PTEN/MMAC1 gene abnormalities in endometrial carcinomas but a low frequency in cervical carcinomas. 10657903 2000
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 Biomarker group BEFREE The p53 gene appears to be involved in the process of transformation to the anaplastic phenotype and the PTEN gene in the development of follicular adenomas but not carcinomas. 10865036 2000
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 GeneticVariation group BEFREE PTEN deletions were detected in 19% of no special type, 9% of lobular, 4% of tubular cancers and 46% in carcinomas with medullary features. 26672755 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 GeneticVariation group BEFREE A loss of chromosome 10 was detected in five carcinomas with missense PTEN/MMAC1 mutations (71%). 11801303 2002
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 Biomarker group BEFREE These conditions recently have been molecularly elucidated, and some of the genes responsible for them (including STK11/LKB1 and PTEN, the genes responsible for PJS and CD, respectively) have already been investigated in series of sporadic ovarian lesions, mostly carcinomas. 12144681 2002
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 AlteredExpression group BEFREE To investigate the role of PTEN and matrix metalloproteinase-7 (MMP-7) expression in tumorigenesis and progression of gastric carcinoma, their expression in 113 gastric carcinomas was studied by immunohistochemistry. 14516315 2003
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 GeneticVariation group BEFREE It was possible to distinguish high grade serous carcinomas with BRCA1 mutations from those with epigenetic BRCA1 loss: tumours with BRCA1 mutations typically had decreased PTEN mRNA levels while those with epigenetic loss of BRCA1 had copy number gain of PIK3CA. 18208621 2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 Biomarker group BEFREE The PTEN gene is inactivated in a significant proportion of prostate carcinomas, particularly metastatic prostate cancers. 9769364 1998
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 AlteredExpression group BEFREE Of 310 consecutive gastric carcinomas, 62 cases (20%) showed expression loss of PTEN. 11896207 2002