Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
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0.370 | AlteredExpression | group | BEFREE | Cutaneous neuroendocrine (Merkel cell) carcinoma most often arises de novo in the background of a clonally integrated virus, the Merkel cell polyomavirus, and is notable for positive expression of retinoblastoma 1 (RB1) protein and low expression of p53 compared with the rare Merkel cell polyomavirus-negative Merkel cell carcinomas. | 26022453 | 2015 | ||||
|
0.370 | GeneticVariation | group | BEFREE | In virus-positive tumors, a portion of the viral genome, the large T antigen, may inactivate RB1, and in virus-negative Merkel cell carcinomas truncating mutations in the RB1 gene have been identified. | 25446844 | 2014 | ||||
|
0.370 | GeneticVariation | group | BEFREE | Allelic loss at TP53 seems to arise independently of LOH at the RB1 gene in carcinomas of the uterine corpus in humans. | 16293976 | 2005 | ||||
|
0.370 | Biomarker | group | CTD_human | Deregulation of the cyclin D1/Cdk4 retinoblastoma pathway in rat mammary gland carcinomas induced by the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. | 14522882 | 2003 | ||||
|
0.370 | GeneticVariation | group | BEFREE | Inactivation of pRB by gross structural alterations or point mutations in the RB-1 gene has been described in a variety of human tumors, including retinoblastomas, osteosarcomas, and small cell lung carcinomas. | 9192669 | 1997 | ||||
|
0.370 | GeneticVariation | group | BEFREE | Our data therefore suggest that major alterations affecting the RB1 gene are rather infrequent in human gastric carcinomas. | 7947078 | 1994 | ||||
|
0.370 | GeneticVariation | group | BEFREE | No alterations in exon 21 of the RB1 gene in sarcomas and carcinomas of the breast, colon, and lung. | 1381957 | 1992 | ||||
|
0.370 | Biomarker | group | BEFREE | One-third of bladder carcinomas surveyed also carry altered or absent p105-Rb. | 2181449 | 1990 |