Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 AlteredExpression group BEFREE We investigated the expression of bcl-2, estrogen receptor alpha (ER-alpha), caspase-3, -8, -9, proliferating cell nuclear antigen (PCNA) and Ki-67 in canine mammary carcinomas. 29565181 2018
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker group BEFREE In this study, we present preclinical evidence for a strategy to eradicate advanced breast cancers by targeting the BCL-2 homolog Nrh/BCL2L10, which we discovered to be overexpressed in >45% of a large cohort of breast invasive carcinomas. 29330143 2018
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 AlteredExpression group BEFREE Using primary carcinomas as well as carcinoma-derived cell lines, we also demonstrate that these tumors are intrinsically resistant to apoptosis due to high levels of expression of the Bcl2 family members, Bcl2a1 (Bcl2a1a) and Mcl1, and can be effectively targeted by Obatoclax, a small-molecule pan-inhibitor of the Bcl2 family. 25012986 2014
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker group BEFREE MiR-125 targets a number of genes such as transcription factors, matrix-metalloprotease, members of Bcl-2 family and others, aberrance of which may lead to abnormal proliferation, metastasis and invasion of cells, even carcinomas. 23321005 2013
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker group BEFREE In the current study, we evaluated the relationship between expression ratio of mRNAs for the antiapoptotic protein Bcl-2 and the proapoptotic protein Bax (the Bcl-2/Bax ratio) in peripheral blood mononuclear cells and clinical outcomes in patients with head and neck carcinomas. 23479508 2013
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 AlteredExpression group BEFREE Most cases showed reduced reactivity for Beclin 1 (62%) and Bcl-2 (82%) proteins, almost half of our sample revealed strong BNIP3 expression (57%), whereas most of the carcinomas strongly expressed Glut 1 antigen (71%). 23216071 2013
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker group BEFREE Human carcinomas often show resistance to cisplatin and Bcl-2 is associated with resistance to cisplatin. 21618512 2012
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 AlteredExpression group BEFREE Significantly higher BCL2 mRNA expression was observed in primary prostate carcinomas derived from patients with the AA, compared to CC, genotype. 21207420 2011
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 AlteredExpression group BEFREE Negative expression of bcl-2 was correlated with poorly differentiated carcinomas (p<0.0001), as well as with positive expression of p53 (p<0.0001) and Ki-67 (p<0.0001). 21621926 2011
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker group BEFREE CXCL12 producing carcinomas cultured on poly-HEMA displayed heightened Bim and loss of Mcl-1 and Bcl-2 preceding cytochrome c release, and caspase-9 activation. 20877573 2010
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker group BEFREE The decreased detection of active caspase-3 and ssDNA and the increased presence of Bcl-2 in T1 carcinomas suggest that alterations in interrelated apoptosis markers may play an important role in the progression of urothelial carcinoma from a superficially infiltrating to a muscle invading tumour and would help to better characterise a subpopulation of T1 carcinomas that could profit from early cystectomy or more aggressive adjuvant chemotherapy. 20025478 2010
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker group BEFREE In conclusion, increased apoptosis and expression of Bax, not Bcl-2 or the Bax/Bcl-2 ratio, may play some role in the relatively lower incidence of human small intestinal carcinomas. 19729672 2009
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 AlteredExpression group BEFREE Overexpression of Bcl-2 family proteins has been found in a variety of aggressive human carcinomas, including pancreatic cancer, suggesting that specific agents targeting Bcl-2 family proteins would be valuable for pancreatic cancer therapy. 19318573 2009
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker group BEFREE Two hundred and twenty-six resected and paraffin-embedded colon carcinomas were analysed by immunostaining using monoclonal antibodies for Bcl-2. 19027288 2009
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker group BEFREE Furthermore, deleted in pancreatic carcinoma locus 4 overexpression was inversely associated with Bcl-2 immunostaining (P < .01), and the apoptosis index in deleted in pancreatic carcinoma locus 4-positive carcinomas (8.65 +/- 1.46) was much higher than that in deleted in pancreatic carcinoma locus 4-negative carcinomas (2.12 +/- 0.04) (P < .05). 18620728 2008
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker group BEFREE Our data indicate similar cell turnover during tumorigenesis of early and advanced cancer. p53 and bcl-2 protein accumulation is more intense in gastric mucosa adjacent to advanced tumors and p53 immunoreactivity peaks in advanced carcinomas. 18063429 2008
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 AlteredExpression group BEFREE Bcl-2 expression neither influenced the incidence nor the multiplicity of papillomas upon chemical tumour induction with 7,12-dimethylbenz[a]anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA), nor their progression to carcinomas. 19035317 2008
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 AlteredExpression group BEFREE EBV is not related to the overexpression of Bcl-2 and c-Myc (nuclear) in gastric carcinomas; however, the results point to a possible EBV involvement with the transport mechanisms of the nuclear membrane, resulting in cytoplasmic c-Myc accumulation. 18382371 2008
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker group BEFREE The expression of hexokinase 2 (HK2), Bcl-2 and several mitochondria-related gene products were investigated by immunohistochemistry in 257 consecutive human gastric carcinomas, and the results were compared with the clinicopathological characteristics. 17352240 2007
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 GeneticVariation group BEFREE In lymph node-negative cases, the (-938C>A) SNP was both significantly related with the immunohistochemically determined level of Bcl-2 expression (P = 0.044) and the survival of patients with Bcl-2-expressing carcinomas (P = 0.006). 17908970 2007
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 AlteredExpression group BEFREE These findings indicate that clusterin and bcl-2 are upregulated in laryngeal carcinomas and their expression is related to the invasiveness of these tumors. 16675913 2006
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker group BEFREE Because the majority of colon carcinomas are known to overexpress antiapoptotic proteins such as survivin and Bcl-2 and show only limited ability to undergo apoptosis, we hypothesized that the ability of sulindac to cause regression of adenomas and to inhibit colon carcinogenesis is mediated, at least in part, by down-regulation of one or more of these antiapoptotic proteins. 14610217 2004
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 AlteredExpression group BEFREE Bcl-X and Bcl-2 are co-expressed in 89% of NPCs whereas their expression is mutually exclusive in other head and neck carcinomas (particularly squamous cell carcinomas, SCC). 12893071 2003
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 Biomarker group BEFREE A potential functional role for changes in bcl-2 family gene expression in Ad.mda-7-induced apoptosis was suggested by the finding that forced overexpression of bcl-x(L) or bcl-2 differentially diminished the apoptotic effect of Ad.mda-7 in prostate carcinomas. 14647471 2003
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.400 AlteredExpression group BEFREE Bcl-2 was strongly expressed in oncocytomas, whereas Ki-67 and p53 were much less expressed in oncocytomas than in carcinomas. 12766581 2003