Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.400 Biomarker group BEFREE Furthermore, these key aspartate-producing players are specifically repressed in VHL-deficient human renal carcinomas, a paradigmatic tumor type in which HIF1α acts as a tumor suppressor, highlighting the in vivo relevance of these findings. 30811976 2019
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.400 AlteredExpression group BEFREE VHL inactivation is a key oncogenic event for renal carcinomas. 30006568 2018
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.400 GeneticVariation group BEFREE Most of the clear cell carcinomas (sporadic as well as familial) have mutations and deletions in the VHL gene located at 3p (p3.25). 29465421 2018
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.400 Biomarker group BEFREE We report a case of a female patient of 37 years diagnosed VHL and intervened on several occasions by cerebral hemangioblastoma and renal carcinomas. 27055912 2017
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.400 AlteredExpression group BEFREE While the inactivation of VHL gene can be found in the majority of clear cell carcinomas, different molecular mechanisms are involved into pRCC biology. 26052049 2015
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.400 Biomarker group BEFREE The prevalence of TP53 mutations in relation to VHL status may differ between clear-cell and other renal carcinomas. 20137853 2010
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.400 GeneticVariation group BEFREE Somatic VHL mutations are also common in sporadic clear cell renal carcinomas. 17255293 2007
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.400 Biomarker group BEFREE Molecular and genetic studies have identified functional loss of the von Hippel-Lindau (VHL) gene as a frequent and crucial event in the development of the malignant phenotype of clear cell renal carcinomas. 17575159 2007
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.400 AlteredExpression group BEFREE Inactivation of the VHL gene is responsible for the autosomal dominant condition von Hippel-Lindau (VHL) disease and is implicated in most sporadic clear cell renal carcinomas. 16775032 2006
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.400 Biomarker group CTD_human Lung cancer susceptibility in Fhit-deficient mice is increased by Vhl haploinsufficiency. 16061637 2005
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.400 Biomarker group BEFREE The far lower frequency of clear cell carcinomas and VHL alterations compared with adults suggests that renal cell carcinomas in young patients have a unique genetic background. 15316311 2004
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.400 Biomarker group BEFREE Loss of von Hippel-Lindau (VHL) protein function results in an autosomal-dominant cancer syndrome known as VHL disease, which manifests as angiomas of the retina, hemangioblastomas of the central nervous system, renal clear-cell carcinomas and pheochromocytomas. 15162797 2004
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.400 Biomarker group BEFREE To address the aberrant promoter methylation profiles of MSI-H gastric carcinomas, promoter methylation of six genes (hMLH1, p16(INK4A), E-cadherin, Rb, RASSF1A, and VHL) and CpG island methylator phenotype (CIMP) were explored in 36 MSI-H gastric carcinomas and the results were compared with those of 43 microsatellite-stable (MSS) gastric carcinomas. 12692837 2003
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.400 GeneticVariation group BEFREE Biallelic inactivation of the von Hippel-Lindau tumor suppressor gene (VHL) is linked to the development of hereditary (VHL-associated) and sporadic clear-cell renal carcinomas as well as other abnormalities. 14691554 2003
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.400 AlteredExpression group BEFREE Somatic mutations of the VHL gene were detected only in clear cell renal carcinomas that overexpressed HIF-1alpha. 11431362 2001
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.400 AlteredExpression group BEFREE We semiquantitatively analyzed 29 renal carcinomas (22 clear cell, 5 chromophilic, 2 chromophobic tumors) for VHL mRNA, and VEGF expression for morphology and tumor size. 10475065 1999
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.400 AlteredExpression group BEFREE Inherited and sporadic clear cell renal carcinomas are characterized by inactivation of both copies of the VHL gene by mutation, and/or by hypermethylation. 9140397 1997
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.400 GeneticVariation group BEFREE Approximately 57% of all renal carcinomas of the clear cell type analyzed revealed a mutation in the von Hippel-Lindau disease (VHL) gene. 9059819 1997
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.400 GeneticVariation group BEFREE The von Hippel-Lindau tumor suppressor gene at 3p25-26 is found to be mutated in the nondeleted allele in 57% of these sporadic clear cell carcinomas. 8959640 1996
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.400 GeneticVariation group BEFREE The authors have analyzed VHL gene alterations on chromosome 3p in sporadic human colon carcinomas and adenomas using modified microdissection techniques. 8617456 1996
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.400 GeneticVariation group BEFREE Clear cell renal carcinomas are most frequently characterized by loss of function of both copies of the von Hippel-Lindau (VHL) disease gene, suggesting that the VHL gene product plays an important role in regulating renal cell proliferation. 7585510 1995
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.400 Biomarker group BEFREE Mutational inactivation and allelic loss of the von Hippel-Lindau (VHL) gene appear to be causal events for the majority of spontaneous clear-cell renal carcinomas. 7937876 1994
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.400 Biomarker group BEFREE The identification of VHL mutations in a majority of localized and advanced sporadic renal carcinomas and in a second form of hereditary renal carcinoma indicates that the VHL gene plays a critical part in the origin of this malignancy. 7915601 1994
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.400 GeneticVariation group BEFREE In addition, loss of heterozygosity of the VHL gene was observed in 16 (84%) of 19 informative clear cell renal carcinomas. 8187067 1994