Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 AlteredExpression group BEFREE Longstanding molecular observations implicate PTEN inactivation as a major driver of endometrioid carcinomas; TP53 inactivation as a major driver of most serous carcinomas, some high-grade endometrioid carcinomas, and many uterine carcinosarcomas; and inactivation of either gene as drivers of some clear cell carcinomas. 30332563 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 GeneticVariation group BEFREE The PTENP1 Pseudogene, Unlike the PTEN Gene, Is Methylated in Normal Endometrium, As Well As in Endometrial Hyperplasias and Carcinomas in Middle-Aged and Elderly Females. 29713518 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 Biomarker group BEFREE Use of Sox9-Cre-LoxP-based approach to coordinately delete PTEN and activate Kras in the adult mouse resulted in not only development of low-grade biliary lesions (ICC and extrahepatic bile duct carcinoma, ECC) but also pancreatic carcinomas. 29452147 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 Biomarker group BEFREE We examined the diagnostic and prognostic value of altered reticulin framework and the immunoprofile of biomarkers including IGF-2, proteins involved in cell proliferation and mitotic spindle regulation (Ki67, p53, BUB1B, HURP, NEK2), DNA damage repair (PBK, γ-H2AX), telomere regulation (DAX, ATRX), wnt-signaling pathway (beta-catenin) and PI3K signaling pathway (PTEN, phospho-mTOR) in a tissue microarray of 50 adenomas and 43 carcinomas that were characterized for angioinvasion as defined by strict criteria, Weiss score, and mitotic rate-based tumor grade. 28877067 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 Biomarker group BEFREE PTEN was preserved in 166 (59%) tumors, partially lost in 38 (14%), and absent in 75 (27%), with lower expression in malignant mesotheliomas compared to carcinomas, though not significantly (p = 0.084). 29170871 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 AlteredExpression group BEFREE We assessed the relationship between ERG and PTEN protein expression in cribriform architecture prostatic carcinomas and adjacent acinar non-cribriform carcinoma and determined the interobserver variability in assessment of these markers. 27913052 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 GeneticVariation group BEFREE PTEN mutations were found in 7 of 15 cases (47%) (4 undifferentiated and 3 dedifferentiated carcinomas). 28498284 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 AlteredExpression group BEFREE It was reported that the E3 ubiquitin ligase neural precursor cell expressed developmentally downregulated gene (NEDD4) (also known as NEDD4-1) negatively regulated phosphatase and tensin homolog deleted on chromosome 10 protein levels through poly-ubiquitination and proteolysis in carcinomas of the prostate, lung, and bladder. 28714370 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 Biomarker group BEFREE Enhanced efficacy of AKT and FAK kinase combined inhibition in squamous cell lung carcinomas with stable reduction in PTEN. 28881794 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 Biomarker group BEFREE PTEN serves as a barrier for SENP1-mediated prostate carcinogenesis as SENP1-Tg mice develop invasive carcinomas only after PTEN reduction. 27852060 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 GeneticVariation group BEFREE PIK3CA mutations occurred in 2 (2/13, 15%) ambiguous carcinomas and PTEN mutations in 1 (1/7, 14%) mixed and 1 (1/13, 8%) ambiguous carcinoma. 26975040 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 Biomarker group BEFREE The E3 ubiquitin ligase NEDD4 (also known as NEDD4-1) has been reported to negatively regulate PTEN protein levels through poly-ubiquitination and proteolysis in carcinomas of the prostate, lung, and bladder, but its effect on PTEN in the breast has not been studied extensively. 26276352 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 GeneticVariation group BEFREE PTEN deletions were detected in 19% of no special type, 9% of lobular, 4% of tubular cancers and 46% in carcinomas with medullary features. 26672755 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 Biomarker group BEFREE This could be seen in all cancers, in the subsets of TMPRSS2:ERG positive or negative, PTEN deleted or undeleted carcinomas (p < 0.0001 each). 25894226 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 AlteredExpression group BEFREE Furthermore, tankyrases were up-regulated and negatively correlated with PTEN expression in human colon carcinomas. 25547115 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 Biomarker group BEFREE Genetic studies have demonstrated that endometriotic lesions have mutations in genes directly related to neoplasms, in particular the p53, KRAS, PTEN, and ARID1A genes, which suggests a direct transition from a subset of endometriotic lesions to invasive carcinomas. 23962574 2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 GeneticVariation group BEFREE PIK3CA mutations and PTEN loss in salivary duct carcinomas. 23851329 2013
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 Biomarker group BEFREE Loss of PTEN protein was found in thyroid adenomas and carcinomas from all 22 (100%) PTEN(Mut+) CS/CSL patients. 22962422 2012
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 AlteredExpression group BEFREE Down-regulation of PTEN may promote a progressive phenotype of colon carcinomas. 21498707 2011
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 Biomarker group BEFREE Mutation analysis of tumor suppressor gene PTEN in patients with gastric carcinomas and its impact on PI3K/AKT pathway. 20514448 2010
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 Biomarker group BEFREE Molecular alterations of EGFR and PTEN in prostate cancer: association with high-grade and advanced-stage carcinomas. 20208477 2010
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 AlteredExpression group BEFREE PAX2 and PTEN expression were markedly reduced or absent in 12 of 12 and 4 of 12 tubal intraepithelial carcinomas. 20562848 2010
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 GeneticVariation group BEFREE In humans, PTEN deletion is associated with follicular adenomas and carcinomas, and in mice, deletion of one Pten allele causes mild thyroid hyperplasia. 19797117 2009
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 Biomarker group BEFREE Thus, Par-4 is absent in a high percentage of human prostate carcinomas, and its loss is concomitantly associated with PTEN loss. 19625770 2009
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 Biomarker group BEFREE However, little is known about the profile of PTEN gene in oral carcinomas. 18497947 2008