Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE To the best of our knowledge, anti-cancer activity of this chimeric protein against colon cancer that overexpresses epidermal growth factor receptor (EGFR) has not yet been studied. 30471512 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE Y‑box‑binding protein 1 inhibits apoptosis and upregulates EGFR in colon cancer. 30864697 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE The results of our studies demonstrate that BODIPY bioconjugates bearing the EGFR-targeting peptide 3PEG-LARLLT show promise as near-IR fluorescent imaging agents for colon cancers overexpressing EGFR. 30835998 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE Blockade of IL-6 trans-signaling therefore offers a new therapeutic window downstream of the EGF-R for the treatment of colon cancer and possibly of other EGF-R related neoplastic diseases. 31694340 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE A <i>MEK1</i><sup>V211D</sup> mutation developed in a patient with <i>BRAF</i><sup>K601E</sup> colon cancer on MEK and EGFR inhibitors. 31227518 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE Left-sided colon cancer is more sensitive to anti-EGFR antibodies than right-sided, although the mechanism is unclear. 31519572 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression disease BEFREE Furthermore, Sushi-IL15-Apo increased the anti-tumor effect of a murine anti-EGFR mAb in Rag1<sup>-/-</sup> mice bearing subcutaneous MC38 colon cancer transfected to express EGFR. 29308327 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE Antibody-dependent cell-mediated cytotoxicity (ADCC) significantly contributes to the anti-tumor effects of monoclonal antibodies, including cetuximab, an epidermal growth factor receptor (EGFR)-targeted monoclonal antibody that is frequently added to chemotherapy in the treatment of colon cancer. 30090970 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE Extracellular galectin-3 increased colon cancer cell migration, which correlated with the EGFR. 30210679 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE A Molecularly Annotated Model of Patient-Derived Colon Cancer Stem-Like Cells to Assess Genetic and Nongenetic Mechanisms of Resistance to Anti-EGFR Therapy. 28974546 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE Here we report that the newly synthesized β-phenylacrylic acid derivatives, MHY791 and MHY1036 (MHYs), bind to epidermal growth factor receptor (EGFR) tyrosine kinase domains and function as EGFR inhibitors, having anti-cancer activities selectively in wild-type KRAS colon cancer. 30158525 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE The extremely potent miR-143#12 enabled us to understand K-Ras signaling networks and shut them down by combination treatment with this miRNA and EGFR inhibitor in K-Ras-driven colon cancer cell lines. 29498789 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE HCRP-1 regulates EGFR-AKT-BIM-mediated anoikis resistance and serves as a prognostic marker in human colon cancer. 30518879 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE In the present study, we first determined the expression of miR-20b by RT-PCR and the levels of a disintegrin and metalloprotease 9 (ADAM9) and epidermal growth factor receptor (EGFR) by western blotting in CC and adjacent non-cancerous tissues from 5-FU-sensitive or -resistant CC patients. 27878272 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE EGFR-targeted nonviral NIS gene transfer for bioimaging and therapy of disseminated colon cancer metastases. 29190908 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE The antitumor efficacy of UCB-NK cells against cetuximab-resistant human EGFR<sup>+</sup> RAS<sup>mut</sup> colon cancer cells was further confirmed in an <i>in vivo</i> preclinical mouse model where UCB-NK showed enhanced antitumor cytotoxicity against colon cancer independent of EGFR and RAS status. 28220124 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression disease BEFREE Our approach enabled visualization of the status of EGFR expression, allowing quantitative evaluation in whole tumors, which correlated well with the EGFR expression levels in mouse or patients-derived colon cancers. 28819451 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE HT may be a competent therapeutic agent in CC enhancing the effects of EGFR inhibitors. 29137335 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE These data indicate that mTOR inhibitor resistance in invasive intestinal tumors involves feedback signaling from both cancer epithelial and stromal cells, highlighting the role of tumor microenvironment in drug resistance, and support that simultaneous inhibition of mTOR and EGFR or MEK may be more effective in treating colon cancer. 28759045 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE In vitro cytotoxicity experiments using colon cancer primary tumors and cell lines COLO320, Caco-2, SW620, SW480 and HT-29, demonstrated that PBNK cells are cytotoxic for a range of tumor cells, regardless of EGFR, RAS or BRAF status and at low E:T ratios. 27314237 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE EGFR knockout in colon cancer cells inhibited macrophage-induced promotion of xenograft tumor growth. 27683110 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE Further, active targeting against CD44 and EGFR receptors was validated in breast and colon cancer cell lines. 26238079 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation disease BEFREE Most BRAF (V600E) mutant melanomas are sensitive to selective BRAF inhibitors, but BRAF mutant colon cancers are intrinsically resistant to these drugs because of feedback activation of EGFR. 26365186 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE KRAS mutations also induce anti-EGFR antibody resistance in adenocarcinoma such as colon cancer. 25589625 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation disease BEFREE Mutations at the K-RAS locus in colon cancer cells are frequently associated with lack of responsiveness to therapy with EGFR inhibitors, as a consequence of the activation of Ras-dependent intracellular signals. 25675084 2015