×
Entrez Id:
3309
Gene Symbol:
HSPA5
HSPA5
0.100
AlteredExpression
disease
BEFREE
Supplementation of p-CA downregulated Grp78 and activated UPR mediated apoptosis both in in vitro and in vivo models of colon cancer .
29879413
2018
×
Entrez Id:
3309
Gene Symbol:
HSPA5
HSPA5
0.100
AlteredExpression
disease
BEFREE
Furthermore, high levels of GRP78 expression have been shown to increase the risk of malignancy and metastasis in prostate and colon cancer .
28551635
2017
×
Entrez Id:
3309
Gene Symbol:
HSPA5
HSPA5
0.100
Biomarker
disease
BEFREE
Here, we detected its effects on DLD-1 and SW480 (two human colon cancer cell lines) and investigated the dynamic relationship between the 78-kDa glucose-regulatory protein (GRP78 ) and the phosphoinositide 3-kinase (PI3K)/Akt pathway.
26225471
2015
×
Entrez Id:
3309
Gene Symbol:
HSPA5
HSPA5
0.100
Biomarker
disease
BEFREE
GRP78 mediates the therapeutic efficacy of curcumin on colon cancer .
25277658
2015
×
Entrez Id:
3309
Gene Symbol:
HSPA5
HSPA5
0.100
Biomarker
disease
BEFREE
However, the role of GRP78 in the metastasis of colon cancer is unclear.
25431258
2015
×
Entrez Id:
3309
Gene Symbol:
HSPA5
HSPA5
0.100
AlteredExpression
disease
BEFREE
The level of GRP78 expression may determine the therapeutic efficacy of 17-DMAG against colon cancer cells.
25618598
2015
×
Entrez Id:
3309
Gene Symbol:
HSPA5
HSPA5
0.100
AlteredExpression
disease
BEFREE
Here we report that forced GRP78 expression promotes colon cancer cell migration and invasion through upregulating MMP-2, MMP-9 and especially uPA production.
24314144
2014
×
Entrez Id:
3309
Gene Symbol:
HSPA5
HSPA5
0.100
AlteredExpression
disease
BEFREE
We first checked the expression of GRP78 in human normal and colon cancer tissues and two colon cancer cell lines.
23759331
2013
×
Entrez Id:
3309
Gene Symbol:
HSPA5
HSPA5
0.100
Biomarker
disease
BEFREE
This study demonstrates the significance of cell surface GRP78 in colon cancer , which may be used as a marker for reduced tumorigenicity.
22945507
2012
×
Entrez Id:
3309
Gene Symbol:
HSPA5
HSPA5
0.100
AlteredExpression
disease
BEFREE
GRP78 knockdown enhances apoptosis via the down-regulation of oxidative stress and Akt pathway after epirubicin treatment in colon cancer DLD-1 cells.
22529978
2012
×
Entrez Id:
3309
Gene Symbol:
HSPA5
HSPA5
0.100
AlteredExpression
disease
BEFREE
DHA treatment induced apoptosis in three colon cancer cell lines (HT-29, HCT116 and SW480), and inhibited their total and surface GRP78 expression.
22898250
2012
×
Entrez Id:
3309
Gene Symbol:
HSPA5
HSPA5
0.100
AlteredExpression
disease
BEFREE
One of the identified proteins, GRP78 , exhibited a marked up-regulation in colon cancer tissue.
16182273
2006
×
Entrez Id:
3309
Gene Symbol:
HSPA5
HSPA5
0.100
AlteredExpression
disease
BEFREE
These observations prompted us to examine whether 6-AN pre-treatment can result in the over-expression of GRP78 in human colon cancer cell lines and, if so, whether this increase is associated with sensitization to DNA cross-linking agents outlined above.
10198218
1999