|
HSP90AA1
|
0.100 |
Biomarker
|
disease |
BEFREE |
In mice, chronic non-heat shock-inducing HSP90 inhibition slowed progression of colon cancer implants, but only in syngeneic animals with intact immune function.
|
31213460 |
2019 |
|
HSP90AA1
|
0.100 |
Biomarker
|
disease |
BEFREE |
PADI3 plays an antitumor role via the Hsp90/CKS1 pathway in colon cancer.
|
31708688 |
2019 |
|
HSP90AA1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Treatment of human colon cancer HCT116 cells with nanoparticles laden with LB76 produces the typical phenotype associated with Hsp90 inhibition, providing evidence of a therapeutically active payload.
|
30920570 |
2019 |
|
HSP90AA1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Blocking Hsp90 could enable effective antitumor effects in many tumor types, such as multiple myeloma and colon cancer.
|
31244417 |
2019 |
|
HSP90AA1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Epigenetic effects of inhibition of heat shock protein 90 (HSP90) in human pancreatic and colon cancer.
|
28583846 |
2017 |
|
HSP90AA1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although previous studies have suggested a role for the molecular chaperone Hsp90 in regulating the TGF-β pathway, the level at which this occurs as well as the consequences in terms of colon cancer metastasis are unknown.
|
28302086 |
2017 |
|
HSP90AA1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Although AUY922 inhibited HSP90 activity with comparable potency in colon cancer cells irrespective of their KRAS mutational statuses, those with mutant KRAS were markedly more sensitive to AUY922-induced apoptosis.
|
26832792 |
2016 |
|
HSP90AA1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, these results reveal that reactivation of ERK and Akt associated respectively with the activity of mutant BRAF and CDC37 renders mutant BRAF colon cancer cells resistant to AUY922, with implications of co-targeting mutant BRAF and/or CDC37 and HSP90 in the treatment of mutant BRAF colon cancers.
|
27391062 |
2016 |
|
HSP90AA1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
HCT116/R, a HCT116 colon cancer cell subline carrying acquired resistance to 5-FU, showed increased expression and activation of HSP90's client proteins and transcriptional up-regulation of TYMS.
|
26416450 |
2015 |
|
HSP90AA1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We evaluated the significance of HSP90 and Her2 expression in colon cancer.
|
24733427 |
2014 |
|
HSP90AA1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Of most important, pharmacologically inhibition of Hsp90 or p38γ activity disrupts the complex, decreases K-Ras expression, and selectively inhibits the growth of K-Ras MT colon cancer in vitro and in vivo.
|
24962213 |
2014 |
|
HSP90AA1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Heat shock protein 90 (Hsp90) is a cellular chaperone that is required for the maturation and stability of a variety of proteins that play key roles in colon cancer initiation and progression.
|
25444464 |
2014 |
|
HSP90AA1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here we followed-up on our previous observation that inhibition of Hsp90 may increase ATF3 expression and sought to determine the role of ATF3 in colon cancer.
|
21129190 |
2010 |
|
HSP90AA1
|
0.100 |
Biomarker
|
disease |
BEFREE |
We show that in the colon cancer cells HT-29 the inhibition of the chaperone function of Hsp90 by geldanamycin (GA) enhances the ubiquitinylation of cyclin E and triggers active degradation via the proteasome pathway.
|
18977205 |
2009 |