Gene: LEP ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.400 AlteredExpression disease BEFREE Moreover, leptin induced up-regulation of SIRT1 in human colon cancer (HCT-116) cells. 29427626 2018
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.400 Biomarker disease BEFREE Here in, we investigated the anti-tumor effect of EA in the presence of leptin to reflect on therapeutic use of EA in obesity-linked colon cancer. 27460082 2016
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.400 Biomarker disease BEFREE The results of the present study suggest a role for leptin in the progression of colon cancer to metastatic disease without weight loss. 23558862 2013
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.400 Biomarker disease BEFREE Novel multiplex method to assess insulin, leptin and adiponectin regulation of inflammatory cytokines associated with colon cancer. 22193626 2012
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.400 AlteredExpression disease BEFREE Our results demonstrated that lycopene significantly inhibited leptin-mediated cell invasion and MMP-7 expression in human colon cancer HT-29 cells. 21923160 2011
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.400 GeneticVariation disease BEFREE Adipose tissue secretes factors linked to colon cancer risk including leptin. 19221001 2009
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.400 AlteredExpression disease BEFREE Here we investigated the molecular mechanism by which leptin and VEGF expression are regulated in colon cancer by epidermal growth factor (EGF). 19492417 2009
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.400 Biomarker disease BEFREE These data support an association between LEP and colon cancer. 18059035 2008
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.400 Biomarker disease CTD_human Leptin promotes the growth of Colon 38 cancer cells and interferes with the cytotoxic effect of fluorouracil in vitro. 17354198 2007
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.400 AlteredExpression disease BEFREE Obesity, a risk factor for colon cancer, is associated with elevated serum levels of leptin, a protein produced by adipocytes. 17170030 2007
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.400 AlteredExpression disease BEFREE The secretion of adiponectin and macrophage colony-stimulating factor, as well as leptin and migration inhibitory factor, was significantly upregulated in CD compared with CC and diverticulitis or CC only, respectively. 16775490 2006
Entrez Id: 3952
Gene Symbol: LEP
LEP 		0.400 Biomarker disease BEFREE Leptin stimulates the proliferation of human colon cancer cells in vitro but does not promote the growth of colon cancer xenografts in nude mice or intestinal tumorigenesis in Apc(Min/+) mice. 15857934 2005