Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 AlteredExpression disease BEFREE In particular, the PC-loaded EFM exerted its anti-cancer activity by blocking the cell cycle at the G0/G1 phase and inducing cell apoptosis involving the decrease of Bcl-2/Bax, activation of caspase 3 and release of cytochrome c. This study suggests that co-axial electrospinning is an efficient and effective way to deliver PC and improve its bioavailability; thus, it represents a promising approach for encapsulating functional ingredients for colon cancer prevention. 30806395 2019
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Biomarker disease BEFREE Collectively, our results revealed that ZEB2-AS1 was upregualted and functioned as an oncogene via regulating miR-143/bcl-2 axis in colon cancer. 31497237 2019
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Biomarker disease BEFREE Emodin activated caspases, modulated Bcl-2 family of proteins and reduced mitochondrial membrane potential to induce CoCa cell death. 31011292 2019
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Biomarker disease BEFREE To investigate the molecular mechanisms of cordycepin against colon cancer and in driving apoptosis, p53 and Bcl‑2‑like protein 4‑null (Bax‑/‑) colon cancer HCT116 cell lines were used. 30535479 2019
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Biomarker disease BEFREE We have demonstrated the therapeutic potential of miR-15a in colon cancer. miR-15a inhibits several important genes (<i>BCL2, BMI1, YAP1</i> and <i>DCLK1</i>), decreasing cancer progression and resistance. 29416778 2018
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Biomarker disease BEFREE The present study aimed to explore the role of B-cell lymphoma 2 (BCL-2) in promoting colon cancer development associated with LIN28B. 29669301 2018
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Biomarker disease BEFREE Targeting Bcl-2 proteins via DZNep or BH3 mimetics could increase the therapeutic potential of MDM2-antagonists like Nutlin-3a in colon cancer. 29394130 2018
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 AlteredExpression disease BEFREE The expressions of C-MYC and BCL-2 in colon cancer tissues exhibited high levels of expression, while miR-184 displayed relatively low levels in comparison to the adjacent normal tissues. 28782841 2018
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Biomarker disease BEFREE This investigation was conducted to construct a hypoxia/colorectal dual-specific bidirectional short hairpin RNA (shRNA) expression vector and to transfect it into the colon cancer cell line HT-29 with PEI/chitosan-TBA nanoparticles for the simultaneous knock down of β-catenin and Bcl-2 under hypoxia. 29656061 2018
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 AlteredExpression disease BEFREE Using HCT-116 human colon cancer cell line, expression of AMPK, extracellular signal-regulated kinase (ERK), cyclin D1, and Bcl-2 was investigated and cell cycle arrest was assessed. 27845068 2017
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Biomarker disease BEFREE Reversal of Mutant KRAS-Mediated Apoptosis Resistance by Concurrent Noxa/Bik Induction and Bcl-2/Bcl-xL Antagonism in Colon Cancer Cells. 25548100 2015
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Biomarker disease BEFREE Exosome-Carried microRNA-375 Inhibits Cell Progression and Dissemination via Bcl-2 Blocking in Colon Cancer. 26697569 2015
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 AlteredExpression disease BEFREE Silencing of miR-210 upregulated Bcl-2 expression and reduced the survival fraction of colon cancer cells after radiation treatment. 25385144 2015
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 AlteredExpression disease BEFREE Virosecurinine induces apoptosis by affecting Bcl-2 and Bax expression in human colon cancer SW480 cells. 22570942 2012
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Therapeutic disease RGD High energy shock waves and 5-aminolevulinic for sonodynamic therapy: effects in a syngeneic model of colon cancer. 21214291 2011
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 AlteredExpression disease BEFREE High expressions of Bag-1 and Bcl-2 proteins in colon cancer were found. 20409521 2010
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 AlteredExpression disease BEFREE The loss of Bcl-2 expression appears to be correlated with increase in number of relapses in the stage II colon cancers and could be a potential useful additional histo-prognostic marker in therapy decision making. 19027288 2009
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Biomarker disease CTD_human gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity. 19147571 2009
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 AlteredExpression disease BEFREE Our results indicate that early apoptosis and cell death of human colon cancer cells induced by photodynamic therapy with lysosome-localizing photosensitizer ATX-S10Na (II) are mediated by p53-Bax network and low levels of Bcl-2 and Bcl-x(L) proteins. 17278191 2007
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Biomarker disease CTD_human Bcl-2 overexpression in PhIP-induced colon tumors: cloning of the rat Bcl-2 promoter and characterization of a pathway involving beta-catenin, c-Myc and E2F1. 17404573 2007
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 AlteredExpression disease BEFREE Bcl-XL, an anti-apoptotic protein of Bcl-2 family, is overexpressed in colon cancers. 17534896 2007
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 AlteredExpression disease BEFREE Studies on p53, BAX and Bcl-2 protein expression and microsatellite instability in stage III (UICC) colon cancer treated by adjuvant chemotherapy: major prognostic impact of proapoptotic BAX. 17426704 2007
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Biomarker disease BEFREE Expression of cell survival/death genes: Bcl-2 and Bax at the rate of colon cancer prognosis. 15955446 2005
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 AlteredExpression disease BEFREE We examined whether 5F could affect apoptosis in human colon cancer HT-29 cells, and test whether and how the over-expression of Bcl-2 and Bcl-xL could offset the effect of 5F on cell growth. 15314290 2004
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.600 Biomarker disease BEFREE This study suggested that a PPARgamma-Bcl-2 feedback loop may function to control the life-death continuum in colonic cells and that a deficiency in generation of PPARgamma ligands may precede the development of human colon cancer. 12269390 2002