| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.380 | Biomarker | disease | BEFREE | The aim of the present study was to elucidate the function of Beclin 1 in colon cancer. | 30675309 | 2019 | ||||
|
0.380 | Biomarker | disease | BEFREE | Our study demonstrates that the increased BECN1 accompanied by enhanced autophagy activity is responsible for the TRAIL resistance, and a combination of TRAIL with a PIK3C3-BECN1 inhibitor is a promising therapeutic approach for the treatment of colon cancer. | 31092562 | 2019 | ||||
|
0.380 | AlteredExpression | disease | BEFREE | The normal colon epithelia cell line of CCD-18Co and six colon cancer cell lines with different expression levels of Beclin-1 were used in this study. | 29738069 | 2018 | ||||
|
0.380 | AlteredExpression | disease | BEFREE | This suggests that the pretreatment SUV<sub>max</sub> in <sup>18</sup>F-FDG PET/CT is a useful tool to help predict survival outcome in patients with colon cancer and unresectable liver metastases and may significantly distinguish between patients with low and high levels of Beclin-1 expression (AUC = 0.809, 95% CI: 0.670-0.948, p = 0.001). | 28250335 | 2017 | ||||
|
0.380 | Biomarker | disease | BEFREE | ABHD5 interacts with BECN1 to regulate autophagy and tumorigenesis of colon cancer independent of PNPLA2. | 27559856 | 2016 | ||||
|
0.380 | AlteredExpression | disease | BEFREE | In conclusion, Beclin 1 overexpression was associated with reduced survival in colon cancer patients treated with adjuvant 5-FU. | 23192274 | 2013 | ||||
|
0.380 | Biomarker | disease | CTD_human | Inhibition of autophagy enhances anticancer effects of atorvastatin in digestive malignancies. | 20876807 | 2010 | ||||
|
0.380 | Biomarker | disease | BEFREE | Transfection of the low Beclin 1 gene-expressing colon cancer cell line with the Beclin 1 gene resulted in cell growth inhibition. | 17595761 | 2007 | ||||
|
0.380 | AlteredExpression | disease | BEFREE | UVRAG, a tumour suppressor candidate that is monoallelically mutated at high frequency in human colon cancers, associates with the Beclin1-Bcl-2-PI(3)KC3 multiprotein complex, where UVRAG and Beclin1 interdependently induce autophagy. | 16799551 | 2006 |