| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | Preoperative use of metformin in obese women with endometrioid endometrial cancer (EEC) reduces tumor proliferation and inhibits the mammalian target of rapamycin pathway, though is only effective in select cases. | 31808620 | 2020 | ||||
|
0.080 | Biomarker | disease | BEFREE | Molecular determinants of outcome with mammalian target of rapamycin inhibition in endometrial cancer. | 24166148 | 2014 | ||||
|
0.080 | Biomarker | disease | BEFREE | The search continues: looking for predictive biomarkers for response to mammalian target of rapamycin inhibition in endometrial cancer. | 24651628 | 2014 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Alterations of mTOR gene expression have been implicated in the pathogenesis of endometrioid endometrial cancer however only few studies explored the cause of increased mTOR activation in this malignancy. miRNAs are small, noncoding RNAs, which were proven to regulated gene expression at the posttranscriptional level. | 22920721 | 2012 | ||||
|
0.080 | Biomarker | disease | BEFREE | The combined treatment of EGFR TKI and the mTOR inhibitor provided a synergistic effect by promoting cell death in PTEN-deficient and PTEN-intact endometrial cancer cells, particularly in PTEN-deficient carcinoma cells with up-regulated EGFR activation. | 21952748 | 2012 | ||||
|
0.080 | Biomarker | disease | BEFREE | Metformin promotes progesterone receptor expression via inhibition of mammalian target of rapamycin (mTOR) in endometrial cancer cells. | 21168492 | 2011 | ||||
|
0.080 | Biomarker | disease | BEFREE | Mammalian target of rapamycin (mTOR) inhibitors modulate signaling pathways involved in cell cycle progression, and phase 2 trials for endometrial cancer are currently being conducted. | 19484784 | 2009 | ||||
|
0.080 | PosttranslationalModification | disease | BEFREE | Given that Akt and mTOR phosphorylation also is frequently detected in ovarian and endometrial cancer, we intended to find out to what extent mTOR inhibitor RAD001 (everolimus) and tamoxifen add to each other's effects on growth and apoptosis of cancer cell lines derived from these tissues when given concomitantly. | 16443261 | 2006 |