Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 AlteredExpression disease BEFREE Estrogen receptor (ER), progesterone receptor (PR), and Ki-67 and P53 receptor levels in endometrial curettage material were investigated for their ability to predict lymph node (LN) involvement in patients with endometrioid-type endometrial cancer (EEC). 31395281 2020
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE For endometrial cancer, four molecular subgroups have undergone extensive studies in recent years: POLE ultramutated (POLEmut), mismatch repair-deficient (MMRd), p53 mutant (p53abn) and those EC lacking any of these alterations, referred to as NSMP (non-specific molecular profile). 31846532 2020
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE UBE2C is upregulated by estrogen and promotes epithelial-mesenchymal transition via p53 in endometrial cancer. 31662448 2020
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE The aim of this study was to determine the joint effect of single nucleotide polymorphisms (SNPs) of MDM2, TP53, and CDKN2A (P14ARF) genes on the onset and course of endometrial cancer (EC) in postmenopausal women. 31028217 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE Adding PTEN/TP53 mutation testing to BHLHE22/CDO1-based methylation testing did not improve the detection of endometrial cancer. 31779688 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE This study aimed to determine the in vitro and in vivo properties of sixteen frequently used endometrial cancer (EC) cell lines, including the cell proliferation rate, morphology, hormone receptor expression patterns, PTEN, hMLH1 expression, p53 mutation, karyotype, and tumorigenicity in mouse xenograt model. 30107158 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 AlteredExpression disease BEFREE To examine the expressions of COX-2, p53 and vascular endothelial growth factor (VEGF) in endometrial cancer and their relationships with clinicopathologic characteristics. 30488858 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 AlteredExpression disease BEFREE These results suggest that MHY2256 exerts its anticancer activity through p53 acetylation in endometrial cancer and can be used for targeting hormone-related cancers. 30217020 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 AlteredExpression disease BEFREE Foretinib induces an anti-cancer effect through the anti-phosphorylation of Met, which results in the induction of p53-dependent apoptosis; foretinib was found to exert greater anti-cancer activity in endometrial cancer specimens with wild-type p53 than in specimens with p53 mutations. 29854314 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 AlteredExpression disease BEFREE A simple combination of morphological and immunohistochemical characteristics (tumour type, grade, peritumoral lymphocytes, MLH1, and p53 expression) can assist in prescreening for POLE exonuclease domain mutations in EC, increasing the probability of a mutation being detected from 7% to 33%. 28795426 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE Our objective was to engender synthetic lethality to paclitaxel (PTX), the frontline treatment for endometrial cancer, in tumours with mutant p53 and enhance the therapeutic efficacy using polymeric nanoparticles (NPs). 29203914 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE We evaluated whether DNA damage response biomarkers could further refine this high-risk tumors classification, in particular the heterogeneous "no specific molecular profile" and "TP53 mutated" subsets recently qualified as poor prognosis in high-risk endometrial cancer. 29955143 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE We may conclude that ARID1A, p53 and ß-Catenin are the strongest prognostic factors by analyzing a subgroup of tumor suppressor genes in clear cell and endometrioid subtypes of ovarian and endometrial cancer and may be used along with traditional morphological and clinical characteristics for prognosis. 29451900 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE Long non-coding RNA LINC00672 contributes to p53 protein-mediated gene suppression and promotes endometrial cancer chemosensitivity. 28232485 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE However, TP53 aberrations may not always represent a driving molecular event in a given endometrial cancer with a mutation. 29137657 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE TP53 was silenced in two endometrial cancer cell lines to study its effect on p21 and p63. 28511869 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 AlteredExpression disease BEFREE Associations of 19q12 status with Cyclin E1, URI and p53 expression, and clinico-pathological parameters were tested.Amplification of 19q12 (CCNE1/URI) was found in 10.4% (28/270) and was significantly associated with type II EC (high grade and non-endometrioid; p < 0.0001), advanced FIGO stage (p = 0.001), high Cyclin E1 expression (p = 0.008) and aberrant p53 expression (p = 0.04). 27582547 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE Forty-nine ECs (three tumour blocks/case) were selected with alterations in POLE (n=10), CTNNB1 (n=8), p53 (n=10), mismatch repair (n=11), L1CAM (n=10), and ECs without any of these markers (n=9). 28424422 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE This study indicated that the p53 codon 72 polymorphism may not be associated with endometrial cancer risk. 27327151 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE This meta-analysis revealed a weak association between the codon72 polymorphism of p53 gene and the risk of endometrial cancer. 26749437 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 AlteredExpression disease BEFREE Prognostic significance of L1CAM expression and its association with mutant p53 expression in high-risk endometrial cancer. 26743472 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE Further, inflammatory mediators secreted from CDH1-negative, TP53 mutant endometrial cancer cells induced normal macrophages to express inflammatory-related genes through activation of nuclear factor-κB signaling. 24998851 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE Our data suggest that REGγ is a promising therapeutic target for EC with the p53-R248Q mutation. 25697482 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE MGMT promoter hypermethylation and K-RAS, PTEN and TP53 mutations in tamoxifen-exposed and non-exposed endometrial cancer cases. 24853176 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE Co-occurrence of some MDM2 SNP309 and TP53 codon 72 polymorphisms seems to influence EC risk, involving grading and staging of this neoplasm at the same time. 25316267 2014