Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression disease BEFREE The aim of the present study was to investigate the prognostic value of cytoplasmic (-C) and nuclear epidermal growth factor receptor (EGFR-N) expression in rectal cancer patients following neoadjuvant concurrent chemoradiotherapy (CCRT). 30675212 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE These aberrations may contribute to differential outcomes to anti-epidermal growth factor receptor therapy among patients with right colon, left colon, or rectal cancers. 29128266 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression disease BEFREE Several associations were identified between histogram parameter derived from ADC maps and EGFR, KI 67 and p53 expression in rectal cancer. 29719621 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation disease BEFREE The influence of EGFR pathway mutations on cetuximab-containing rectal cancer preoperative chemoradiation (CRT) is uncertain. 28859058 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation disease BEFREE Right-sided colon cancers had higher rates of microsatellite instability, more frequent aberrant activation of the EGFR pathway including higher <i>BRAF</i> and <i>PIK3CA</i> mutation rates, and increased mutational burden compared to left-sided colon and rectal cancers. 29156800 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE Because of the supposed negative interaction of epidermal growth factor receptor inhibition and chemoradiation therapy, we conducted a phase 2 study using single-agent panitumumab in combination with radiation therapy in patients with RAS wild-type locally advanced rectal cancer. 28870789 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE We have successfully identified significant genes (such as EGFR and UBC) across fungating, polypoid and polypoid & small-ulcer phenotype of rectal cancer. 27062700 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE These results suggest that [(18)F]-FLT PET is a promising imaging biomarker to predict response to neoadjuvant therapy that included EGFR blockade with cetuximab in patients with rectal cancer. 25899481 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation disease BEFREE The pooled analysis results indicated that MTHFR C677T might be correlated with the tumor response to pRCT under the recessive model (CC vs. CTTT) in overall analysis (OR=1.426(1.074-1.894), P=0.014), rectal cancer (OR=1.483(1.102-1.996), P=0.009), and TRG 1-2 vs. 3-5 group (OR=1.423(1.046-1.936), P=0.025), while other polymorphism including MTHFR A1298C, EGFR G497A, and EGFR CA repeat polymorphisms exerted significant association under all genetic models in overall analysis or subgroup analysis. 26456456 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE EGFR ligands and DNA repair genes: genomic predictors of complete response after capecitabine-based chemoradiotherapy in locally advanced rectal cancer. 25026457 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression disease BEFREE We analyzed EGFR, KRAS, BRAF, and PIK3CA mutation status with direct sequencing and epidermal growth factor receptor (EGFR) and Phosphatase and tensin homolog (PTEN) expression status with immunohistochemistry in tumor samples of 82 patients with locally advanced rectal cancer who were enrolled in the IRIX trial (preoperative chemoradiation with irinotecan and capecitabine; n=44) or the ERBIRIX trial (preoperative chemoradiation with irinotecan and capecitabine plus cetuximab; n=38). 22672749 2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression disease BEFREE EGFR and HER3 mRNA expression levels predict distant metastases in locally advanced rectal cancer. 20824716 2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE To establish a causal relationship between the gene expression profiles of angiogenetic molecular markers, including epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1 (HIF-1), in rectal cancer and the local responsiveness to neoadjuvant chemoradiotherapy and subsequent disease recurrence. 20117921 2010
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE Our data show that EGFR GCN and KRAS status are not prognostic factors in LARC treated with preoperative chemoradiation. 20842128 2010
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE Elevated CD133, but not VEGF or EGFR, on FFPE specimens may be a predictive marker of distant recurrence and poor survival after preoperative CRT in rectal cancer. 19724847 2009
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation disease BEFREE Epidermal growth factor receptor gene copy number, K-ras mutation and pathological response to preoperative cetuximab, 5-FU and radiation therapy in locally advanced rectal cancer. 19095777 2009
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression disease BEFREE Gene expression levels of epidermal growth factor receptor, survivin, and vascular endothelial growth factor as molecular markers of lymph node involvement in patients with locally advanced rectal cancer. 17241515 2006
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation disease BEFREE VKORC1 Haplotype A) and somatic mutations (e.g. epidermal growth factor receptor), along with the introduction of FDA approved pharmacogenetic tests (UGT1A1*28) and the initiation of a genotype-guided clinical trial for cancer therapy (TYMS TSER in rectal cancer) have provided the first steps towards the integration of pharmacogenomics into clinical practice. 16651374 2006
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation disease BEFREE There was a significant correlation between EGFR Sp1 -216 G/T polymorphism and treatment response to chemoradiation in locally advanced rectal cancer. 16757132 2006
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease CTD_human A high level of EGFR expression may be a significant predictive molecular marker for decreased tumor downstaging after preoperative chemoradiotherapy in locally advanced rectal cancer. 16839708 2006
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation disease BEFREE Our data suggest that the HER-1 R497K and EGFR intron 1 (CA)(n) repeat polymorphisms may be potential indicators of radiosensitivity in patients with rectal cancer treated with chemoradiation. 15701846 2005
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE The aim of this study was to determine the prognostic value of EGFR status before radiotherapy in a group of patients with locally advanced rectal cancer treated with preoperative radiotherapy. 15816107 2005