<i>MIR182-5p</i> and <i>MIR20a-5p</i> were upregulated in human thyroid cancer and thyroid cancer experimental models and their effects on <i>Pax8</i> and <i>Bcl2</i> were rescued by <i>Klhl14-AS</i> overexpression, confirming <i>Klhl14-AS</i> as a ceRNA for both <i>Pax8</i> and <i>Bcl2</i>.
RT-PCR, immunohistochemical analysis and western blot found that compared with normal tissues, the expressions of TRIP13 and N-cadherin in TC tissues were significantly increased, while the expressions of tetratricopeptide repeat protein 5 (TTC5), p-p53 and E-cadherin were significantly decreased (P < 0.05).
Our results indicate that METTL7B may promote metastasis of thyroid cancer through EMT and may therefore be considered as a potential biomarker for the diagnosis and prognosis of thyroid carcinoma.
The objective of this research was to assess the association of genetic polymorphisms of IL1A and IL1B with the risk of thyroid cancer in a Chinese Han population.
In conclusion, these data indicated that miR-429 could act as a tumour suppressor miRNA and contribute to the development and progression and metastasis of thyroid cancer.
Higher serum levels of FGF21 were found in patients with thyroid cancer than in control participants, and were significantly associated with body mass index (BMI), fasting glucose levels, triglyceride levels, tumor stage, lymphovascular invasion, and recurrence.
Consistently, AXL stimulation with its ligand growth arrest-specific gene 6 (GAS6) increased AKT1- and p65 NF-kB-phosphorylation and promoted survival of thyroid cancer cell lines in culture.
Studies have attributed IL13RA2 to invasion and metastasis in cancers of the ovary, breast, and pancreas, but the pathological role of IL13RA2 in thyroid cancer is still unclear.
Long intergenic non-protein coding RNA 1410 (<i>LINC01410</i>) has been suggested as tumor-promoting gene in colon cancer and gastric cancer, but its role in TC is elusive.